HitPredict

Interactor 1: NLRC4 (Q3UP24)
NLR family CARD domain-containing protein 4 (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)
Gene: NLRC4

Interactor 2: NLRC4 (Q3UP24)
NLR family CARD domain-containing protein 4 (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)
Gene: NLRC4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.67 1.00 0.820

The method score is based on:

Property Details
Experiments 26449474, 26449475, 26585513
Identification Methods 3D electron microscopy, transmission electron microscopy, pull down
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~CARD, NACHT~NACHT, NACHT~NLRC4_HD
Common GO terms GO:0002218 - activation of innate immune response
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006915 - apoptotic process
GO:0006919 - activation of cysteine-type endopeptidase activity involved in apoptotic process
and 10 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024