HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: SH3R3 (Q8TEJ3)
E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4)
Gene: SH3RF3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35563538, 37788672
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016567 - protein ubiquitination GO:0051865 - protein autoubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 882
+	Hs
		1113542 CUL3_HUMAN (1-768): 0: 943: 100.00		SH3R1_HUMAN (46-882): 3.14e-91: 310: 41.06
+	Hs
		302167 CUL3_HUMAN (1-768): 0: 943: 100.00		NEBL_HUMAN (101-882): 3.54e-39: 159: 10.57
+	Hs
		1113058 CUL3_HUMAN (1-768): 0: 943: 100.00		SPTN1_HUMAN (18-464): 2.62e-33: 141: 12.34
+	Hs
		1113337 CUL3_HUMAN (1-768): 0: 943: 100.00		SPD2A_HUMAN (92-881): 2.78e-18: 92.6: 11.06
+	Hs
		987618 CUL3_HUMAN (1-768): 0: 943: 100.00		GRB2_HUMAN (193-254): 4.35e-20: 91.8: 30.65
+	Hs
		1113198 CUL3_HUMAN (1-768): 0: 943: 100.00		ITSN1_HUMAN (520-882): 4.78e-12: 72.2: 6.89
+	Hs
		1114954 CUL4A_HUMAN (10-768): 0: 801: 38.32		SH3R2_HUMAN (703-882): 1.98e-13: 76.4: 17.22
+	Hs
		1112472 CUL1_HUMAN (18-768): 0: 709: 30.57		SPTN1_HUMAN (18-464): 2.62e-33: 141: 12.34