Protein: SPD2A
SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)

Gene: SPD2A, SH3PXD2A
Organism: Homo sapiens
Interactions: 125
UniProt ID: Q5TCZ1

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0002020 - protease binding
GO:0002102 - podosome
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1023019

FGD1
FYVE, RhoGEF and PH domain-containing protein 1

4

15

High-throughput

0.881

High

1060679

SOS1
Son of sevenless homolog 1

1

20

Small-scale

0.747

High

729920

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.735

High

1216071

AF1L2
Actin filament-associated protein 1-like 2

1

0

Small-scale

0.702

High

691100

1433T
14-3-3 protein theta

4

20

High-throughput

0.699

High

966442

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

990328

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.699

High

1049391

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

987697

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.691

High

1211640

FBP1L
Formin-binding protein 1-like

1

14

High-throughput

0.691

High

1216068

MIB1
E3 ubiquitin-protein ligase MIB1

1

4

High-throughput

0.691

High

971621

1433E
14-3-3 protein epsilon

2

6

High-throughput

0.635

High

1105805

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

3

19

Small-scale

0.622

High

208678

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

1

High-throughput

0.618

High

245971

KIF1B
Kinesin-like protein KIF1B

1

11

High-throughput

0.618

High

269561

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

20

High-throughput

0.618

High

557342

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

936353

AFAD
Afadin

1

18

High-throughput

0.618

High

1090142

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

8

High-throughput

0.618

High

1092442

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

19

High-throughput

0.618

High

1124617

SRC8
Src substrate cortactin

1

20

Small-scale

0.618

High

1215997

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

12

High-throughput

0.618

High

1216058

PKHA7
Pleckstrin homology domain-containing family A member 7

1

13

High-throughput

0.618

High

1216064

RFIP2
Rab11 family-interacting protein 2

1

6

High-throughput

0.618

High

1216066

PHLB2
Pleckstrin homology-like domain family B member 2

1

9

High-throughput

0.618

High

1216067

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

17

High-throughput

0.618

High

1216069

KSR1
Kinase suppressor of Ras 1

1

12

High-throughput

0.618

High

1216083

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

10

High-throughput

0.618

High

1216084

TESK2
Dual specificity testis-specific protein kinase 2

1

5

High-throughput

0.618

High

1216088

RTKN
Rhotekin

1

2

High-throughput

0.618

High

1216092

PKHA5
Pleckstrin homology domain-containing family A member 5

1

14

High-throughput

0.618

High

1216104

NGAP
Ras GTPase-activating protein nGAP

1

8

High-throughput

0.618

High

1216110

GAB2
GRB2-associated-binding protein 2

1

16

High-throughput

0.618

High

1216112

STA13
StAR-related lipid transfer protein 13

1

20

High-throughput

0.618

High

930724

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

6

High-throughput

0.611

High

1216094

RTN4
Reticulon-4

2

2

High-throughput

0.611

High

1216099

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.586

High

222111

NCK2
Cytoplasmic protein NCK2

1

18

High-throughput

0.575

High

1216081

ZN764
Zinc finger protein 764

2

2

High-throughput

0.574

High

1216090

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

2

19

Small-scale

0.565

High

412068

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.553

High

1216057

AN34A
Ankyrin repeat domain-containing protein 34A

1

10

High-throughput

0.553

High

1216061

SYDE1
Rho GTPase-activating protein SYDE1

1

20

High-throughput

0.553

High

1216076

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

19

High-throughput

0.553

High

1216078

DEP1B
DEP domain-containing protein 1B

1

20

High-throughput

0.553

High

1216093

TANC2
Protein TANC2

1

4

High-throughput

0.553

High

1216108

HECD1
E3 ubiquitin-protein ligase HECTD1

1

4

Small-scale

0.553

High

1216109

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

20

High-throughput

0.553

High

225605

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

2

High-throughput

0.536

High

909038

NEK4
Serine/threonine-protein kinase Nek4

1

14

High-throughput

0.536

High

1216073

RIN3
Ras and Rab interactor 3

1

20

High-throughput

0.536

High

942264

NETR
Neurotrypsin

1

0

High-throughput

0.517

High

336442

SVIL
Supervillin

1

1

Small-scale

0.481

High

176836

DCLK1
Serine/threonine-protein kinase DCLK1

1

6

High-throughput

0.479

High

230537

KIF1C
Kinesin-like protein KIF1C

1

11

High-throughput

0.479

High

239441

PLIN1
Perilipin-1

1

1

High-throughput

0.479

High

245236

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

10

High-throughput

0.479

High

252079

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

281336

GGYF1
GRB10-interacting GYF protein 1

1

9

High-throughput

0.479

High

339082

NADK
NAD kinase

1

1

High-throughput

0.479

High

345932

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

585795

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

3

High-throughput

0.479

High

637907

NF1
Neurofibromin

1

8

High-throughput

0.479

High

692079

MARK3
MAP/microtubule affinity-regulating kinase 3

1

8

High-throughput

0.479

High

719229

MPIP2
M-phase inducer phosphatase 2

1

2

High-throughput

0.479

High

719336

MPIP3
M-phase inducer phosphatase 3

1

2

High-throughput

0.479

High

730655

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

940991

HDAC4
Histone deacetylase 4

1

7

High-throughput

0.479

High

955273

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

1025556

CDK16
Cyclin-dependent kinase 16

1

1

High-throughput

0.479

High

1045381

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1065712

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

9

High-throughput

0.479

High

1068229

AHNK
Neuroblast differentiation-associated protein AHNAK

1

4

High-throughput

0.479

High

1095388

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

6

High-throughput

0.479

High

1097207

PAK2
Serine/threonine-protein kinase PAK 2

1

20

Small-scale

0.479

High

1113337

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1151992

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

8

High-throughput

0.479

High

1216055

ECM29
Proteasome adapter and scaffold protein ECM29

1

4

High-throughput

0.479

High

1216056

DEN4C
DENN domain-containing protein 4C

1

7

High-throughput

0.479

High

1216059

LARP1
La-related protein 1

1

3

High-throughput

0.479

High

1216060

GGYF2
GRB10-interacting GYF protein 2

1

17

High-throughput

0.479

High

1216063

MARK2
Serine/threonine-protein kinase MARK2

1

8

High-throughput

0.479

High

1216065

MYCPP
C-myc promoter-binding protein

1

7

High-throughput

0.479

High

1216070

RPTOR
Regulatory-associated protein of mTOR

1

7

High-throughput

0.479

High

1216072

NAV1
Neuron navigator 1

1

10

High-throughput

0.479

High

1216074

F110B
Protein FAM110B

1

2

High-throughput

0.479

High

1216075

DEN1A
DENN domain-containing protein 1A

1

7

High-throughput

0.479

High

1216077

HDAC7
Histone deacetylase 7

1

7

High-throughput

0.479

High

1216085

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

1216086

F110A
Protein FAM110A

1

2

High-throughput

0.479

High

1216095

KI13B
Kinesin-like protein KIF13B

1

11

High-throughput

0.479

High

1216096

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

20

High-throughput

0.479

High

1216098

MARK1
Serine/threonine-protein kinase MARK1

1

8

High-throughput

0.479

High

1216102

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1216103

LIMA1
LIM domain and actin-binding protein 1

1

15

High-throughput

0.479

High

1216105

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

5

High-throughput

0.479

High

1216106

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.479

High

1216107

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

1216111

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

1216113

TRAF6
TNF receptor-associated factor 6

1

11

Small-scale

0.479

High

1216115

NEMO
NF-kappa-B essential modulator

1

5

High-throughput

0.479

High

163119

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.458

High

271326

ZBED4
Zinc finger BED domain-containing protein 4

1

0

High-throughput

0.458

High

460556

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

0

High-throughput

0.458

High

1133979

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1216080

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.458

High

1216082

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

1216089

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.458

High

209896

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

1

19

Small-scale

0.457

High

869491

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

8

Small-scale

0.457

High

1199503

KLH22
Kelch-like protein 22

1

8

High-throughput

0.445

High

420566

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.437

High

1129953

MELK
Maternal embryonic leucine zipper kinase

1

7

High-throughput

0.437

High

1155454

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.437

High

1187114

TBC25
TBC1 domain family member 25

1

1

High-throughput

0.437

High

1216079

SRS12
Serine/arginine-rich splicing factor 12

1

6

High-throughput

0.437

High

1216087

LPIN3
Phosphatidate phosphatase LPIN3

1

1

High-throughput

0.437

High

1216097

FA53C
Protein FAM53C

1

1

High-throughput

0.437

High

1216100

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

3

High-throughput

0.437

High

1216101

CING
Cingulin

1

2

High-throughput

0.437

High

1216114

KCTD3
BTB/POZ domain-containing protein KCTD3

1

12

High-throughput

0.437

High

1059863

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

11

Small-scale

0.408

High

1216062

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

5

High-throughput

0.407

High

418195

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

1216091

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025