Protein: MK12
Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)

Gene: MK12, MAPK12
Organism: Homo sapiens
Interactions: 53
UniProt ID: P53778

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

173865

MK13
Mitogen-activated protein kinase 13

4

20

High-throughput

0.903

High

864833

MYLK3
Myosin light chain kinase 3

3

20

High-throughput

0.861

High

854720

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

2

20

Small-scale

0.799

High

864832

PKN1
Serine/threonine-protein kinase N1

1

20

Small-scale

0.747

High

864823

SNTA1
Alpha-1-syntrophin

1

11

Small-scale

0.740

High

864845

SRPK1
SRSF protein kinase 1

1

20

High-throughput

0.735

High

658866

MK01
Mitogen-activated protein kinase 1

1

18

High-throughput

0.691

High

864824

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

10

High-throughput

0.691

High

864825

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

19

High-throughput

0.691

High

864831

MK11
Mitogen-activated protein kinase 11

1

18

High-throughput

0.691

High

864838

CDKL3
Cyclin-dependent kinase-like 3

1

19

High-throughput

0.691

High

864841

MK15
Mitogen-activated protein kinase 15

1

19

High-throughput

0.691

High

864847

SNRK
SNF-related serine/threonine-protein kinase

1

5

High-throughput

0.691

High

864848

ST32B
Serine/threonine-protein kinase 32B

1

20

High-throughput

0.691

High

864849

NLK
Serine/threonine-protein kinase NLK

1

18

High-throughput

0.691

High

864846

PAR11
Protein mono-ADP-ribosyltransferase PARP11

3

6

High-throughput

0.667

High

640224

PTN3
Tyrosine-protein phosphatase non-receptor type 3

2

12

Small-scale

0.648

High

414835

CDK1
Cyclin-dependent kinase 1

1

19

Small-scale

0.647

High

864826

SNTB1
Beta-1-syntrophin

1

8

High-throughput

0.647

High

864839

MAPK5
MAP kinase-activated protein kinase 5

1

20

Small-scale

0.647

High

663967

PTN4
Tyrosine-protein phosphatase non-receptor type 4

2

8

Small-scale

0.635

High

864827

SCRIB
Protein scribble homolog

2

12

Small-scale

0.628

High

226954

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.618

High

239316

CC14B
Dual specificity protein phosphatase CDC14B

1

20

Small-scale

0.618

High

864830

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

10

Small-scale

0.618

High

864836

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

864851

CC14A
Dual specificity protein phosphatase CDC14A

1

20

Small-scale

0.618

High

864852

SRPK3
SRSF protein kinase 3

1

18

High-throughput

0.618

High

864822

DLG1
Disks large homolog 1

2

11

Small-scale

0.595

High

864837

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

7

High-throughput

0.573

High

864820

TERF1
Telomeric repeat-binding factor 1

1

18

High-throughput

0.541

High

864821

GTF2I
General transcription factor II-I

1

3

High-throughput

0.541

High

236901

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

16

High-throughput

0.536

High

301695

TRI37
E3 ubiquitin-protein ligase TRIM37

1

9

High-throughput

0.536

High

864829

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

12

High-throughput

0.536

High

864842

GCN1
Stalled ribosome sensor GCN1

1

7

High-throughput

0.536

High

864844

ERBIN
Erbin

1

6

Small-scale

0.527

High

675819

GCH1
GTP cyclohydrolase 1

1

1

Small-scale

0.515

High

734404

CXG1
Gap junction gamma-1 protein

1

2

High-throughput

0.515

High

394390

A4
Amyloid-beta precursor protein

1

8

High-throughput

0.515

High

203895

HTRA2
Serine protease HTRA2, mitochondrial

1

5

Small-scale

0.501

High

362072

MBP
Myelin basic protein

1

9

Small-scale

0.501

High

496628

TAU
Microtubule-associated protein tau

1

16

Small-scale

0.501

High

864828

PGFRL
Platelet-derived growth factor receptor-like protein

1

7

High-throughput

0.494

High

864834

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

5

High-throughput

0.489

High

864850

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.489

High

864835

CPZIP
CapZ-interacting protein

1

0

Small-scale

0.480

High

260810

H2AY
Core histone macro-H2A.1

1

6

Small-scale

0.479

High

552319

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

650762

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

864840

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

11

Small-scale

0.479

High

864843

SNX27
Sorting nexin-27

1

5

High-throughput

0.479

High

365303

STAT
Statherin

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024