Protein: SH3R1
E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2)

Gene: SH3R1, SH3RF1
Organism: Homo sapiens
Interactions: 97
UniProt ID: Q7Z6J0

Gene Ontology (top 5):
GO:0001764 - neuron migration
GO:0005078 - MAP-kinase scaffold activity
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

728603

AKT2
RAC-beta serine/threonine-protein kinase

3

10

Small-scale

0.872

High

957115

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

7

Small-scale

0.778

High

957775

UBE2N
Ubiquitin-conjugating enzyme E2 N

2

7

Small-scale

0.778

High

728317

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

Small-scale

0.734

High

1159132

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

9

Small-scale

0.724

High

988486

RAC1
Ras-related C3 botulinum toxin substrate 1

5

20

Small-scale

0.712

High

966539

1433G
14-3-3 protein gamma

3

20

High-throughput

0.667

High

906688

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

7

Small-scale

0.647

High

1280028

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

16

Small-scale

0.647

High

211573

SIAH2
E3 ubiquitin-protein ligase SIAH2

2

13

Small-scale

0.644

High

1136656

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

Small-scale

0.633

High

730005

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.628

High

155166

SOCS7
Suppressor of cytokine signaling 7

1

14

High-throughput

0.621

High

320249

SRBS2
Sorbin and SH3 domain-containing protein 2

1

19

High-throughput

0.621

High

324304

ARHGF
Rho guanine nucleotide exchange factor 15

1

15

High-throughput

0.621

High

572838

NCF1
Neutrophil cytosol factor 1

1

19

High-throughput

0.621

High

896808

DYN2
Dynamin-2

1

20

High-throughput

0.621

High

931550

RD23A
UV excision repair protein RAD23 homolog A

1

16

High-throughput

0.621

High

943787

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

19

High-throughput

0.621

High

957621

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

9

High-throughput

0.621

High

1023022

FGD1
FYVE, RhoGEF and PH domain-containing protein 1

1

12

High-throughput

0.621

High

1094306

LCP2
Lymphocyte cytosolic protein 2

1

20

High-throughput

0.621

High

1115544

ASPP2
Apoptosis-stimulating of p53 protein 2

1

11

High-throughput

0.621

High

1138212

ACAP1
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

1

14

High-throughput

0.621

High

1205163

SH319
SH3 domain-containing protein 19

1

19

High-throughput

0.621

High

1280046

SH24A
SH2 domain-containing protein 4A

1

20

High-throughput

0.621

High

363501

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

463616

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

465561

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.618

High

508207

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.618

High

648570

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

1280034

SH3R2
E3 ubiquitin-protein ligase SH3RF2

1

19

Small-scale

0.618

High

1280048

UBQL2
Ubiquilin-2

1

12

High-throughput

0.618

High

878496

PAXI
Paxillin

2

11

High-throughput

0.586

High

1280035

PDC6I
Programmed cell death 6-interacting protein

1

20

Small-scale

0.578

High

1004309

3BP2
SH3 domain-binding protein 2

1

16

High-throughput

0.555

High

1280033

IKBD
NF-kappa-B inhibitor delta

1

7

High-throughput

0.555

High

730719

1433S
14-3-3 protein sigma

1

20

High-throughput

0.554

High

971711

1433E
14-3-3 protein epsilon

1

12

High-throughput

0.554

High

1049493

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

1127572

FAT1
Protocadherin Fat 1

1

1

Small-scale

0.552

High

691184

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

990418

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

1280037

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1280031

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

20

High-throughput

0.494

High

63223

VP37C
Vacuolar protein sorting-associated protein 37C

1

20

High-throughput

0.481

High

133669

WASL
Actin nucleation-promoting factor WASL

1

20

High-throughput

0.481

High

219556

WIPF1
WAS/WASL-interacting protein family member 1

1

20

High-throughput

0.481

High

303248

S22A5
Organic cation/carnitine transporter 2

1

2

High-throughput

0.481

High

928295

ATN1
Atrophin-1

1

20

High-throughput

0.481

High

1055237

MTG8
Protein CBFA2T1

1

3

High-throughput

0.481

High

1097944

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

High-throughput

0.481

High

1116670

RIN1
Ras and Rab interactor 1

1

20

High-throughput

0.481

High

1123021

FHL2
Four and a half LIM domains protein 2

1

11

High-throughput

0.481

High

1148610

SF3A2
Splicing factor 3A subunit 2

1

19

High-throughput

0.481

High

1156533

CCDC6
Coiled-coil domain-containing protein 6

1

12

High-throughput

0.481

High

1280044

RN208
RING finger protein 208

1

3

High-throughput

0.481

High

1280049

EVL
Ena/VASP-like protein

1

20

High-throughput

0.481

High

138195

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

14

High-throughput

0.479

High

214591

WDR62
WD repeat-containing protein 62

1

3

Small-scale

0.479

High

556183

CADH1
Cadherin-1

1

7

High-throughput

0.479

High

642950

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

5

High-throughput

0.479

High

879229

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

Small-scale

0.479

High

1041146

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

1097214

PAK2
Serine/threonine-protein kinase PAK 2

1

20

Small-scale

0.479

High

1113542

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1143178

PLEC
Plectin

1

8

High-throughput

0.479

High

1156126

ZYX
Zyxin

1

18

High-throughput

0.479

High

1228984

RNF43
E3 ubiquitin-protein ligase RNF43

1

20

High-throughput

0.479

High

1280030

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

13

Small-scale

0.479

High

1280036

RFFL
E3 ubiquitin-protein ligase rififylin

1

5

Small-scale

0.479

High

1280052

NINL
Ninein-like protein

1

10

High-throughput

0.479

High

1280045

SEM6A
Semaphorin-6A

1

4

Small-scale

0.464

High

1280032

MTURN
Maturin

1

0

High-throughput

0.460

High

1280050

SUFU
Suppressor of fused homolog

1

0

High-throughput

0.460

High

291408

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

1280043

UNK
RING finger protein unkempt homolog

1

0

High-throughput

0.458

High

372435

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.445

High

51325

NTM2F
NUT family member 2F

1

4

High-throughput

0.439

High

248538

ONEC3
One cut domain family member 3

1

2

High-throughput

0.439

High

1017714

PR20A
Proline-rich protein 20A

1

3

High-throughput

0.439

High

1213419

AT7L2
Ataxin-7-like protein 2

1

2

High-throughput

0.439

High

1257655

XIRP1
Xin actin-binding repeat-containing protein 1

1

2

High-throughput

0.439

High

1280029

GGN
Gametogenetin

1

19

High-throughput

0.439

High

1280038

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.439

High

1280041

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

1

High-throughput

0.439

High

1280042

PRAM
PML-RARA-regulated adapter molecule 1

1

17

High-throughput

0.439

High

1280047

SYP2L
Synaptopodin 2-like protein

1

11

High-throughput

0.439

High

1280051

DLGP4
Disks large-associated protein 4

1

16

High-throughput

0.439

High

106187

APRIO
Alternative prion protein

1

8

High-throughput

0.437

High

1105812

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

20

Small-scale

0.437

High

1241897

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

1280040

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.437

High

870026

KCNJ1
ATP-sensitive inward rectifier potassium channel 1

1

0

Small-scale

0.301

High

1280039

EAF1
ELL-associated factor 1

1

0

High-throughput

0.251

Low

1051671

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025