HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: KCC2G (Q923T9)
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17)
Gene: Camk2g

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	27507650, 28671696, 36417873
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0005737 - cytoplasm GO:0014069 - postsynaptic density GO:0043005 - neuron projection
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1730 Mm			1 529
+	Mm
		659451 SHAN3_MOUSE (1-1730): 0: 626: 100.00		KCC2B_MOUSE (1-529): 0: 584: 81.18
+	Mm
		1115965 SHAN3_MOUSE (1-1730): 0: 626: 100.00		KCC2D_MOUSE (1-529): 0: 555: 78.45
+	Mm
		515229 SHAN3_MOUSE (1-1730): 0: 626: 100.00		KCC2A_MOUSE (1-526): 0: 536: 75.67
+	Mm
		1116168 SHAN3_MOUSE (1-1730): 0: 626: 100.00		KS6A2_MOUSE (10-332): 9.62e-110: 344: 29.57
+	Hs
		1073479 SHAN3_HUMAN (1-1730): 0: 601: 95.21		KS6A1_HUMAN (10-317): 3.33e-109: 343: 30.67
+	Rn
		506766 CSKI1_RAT (55-1403): 1.26e-108: 382: 15.84		KCC2A_RAT (1-526): 0: 536: 75.67
+	Mm
		439494 SHAN3_MOUSE (1-1730): 0: 626: 100.00		KCC4_MOUSE (12-304): 3.38e-71: 236: 43.73
+	Mm
		1116143 SHAN3_MOUSE (1-1730): 0: 626: 100.00		DCLK1_MOUSE (11-272): 9.08e-66: 228: 44.15
+	Hs
		1038922 SHAN3_HUMAN (1-1730): 0: 601: 95.21		KCC2B_HUMAN (276-529): 2.22e-41: 159: 51.71
+	Rn
		1144073 CSKI1_RAT (55-1403): 1.26e-108: 382: 15.84		CSKP_RAT (10-308): 6.11e-84: 280: 46.08
+	Hs
		1083221 ANR52_HUMAN (14-494): 3.38e-78: 284: 16.60		KCC4_HUMAN (10-304): 9.1e-73: 240: 43.43
+	Hs
		166938 ANR28_HUMAN (224-592): 3.91e-43: 174: 14.60		KCC4_HUMAN (10-304): 9.1e-73: 240: 43.43
+	Hs
		159247 CSKI1_HUMAN (954-1663): 8.42e-09: 62.8: 13.73		CSKP_HUMAN (10-308): 7.89e-84: 280: 46.08