HitPredict

Interactor 1: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Interactor 2: SIR7 (Q9NRC8)
NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
Gene: SIRT7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22586326
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 582 Hs			1 400
+	Hs
		403350 LA_HUMAN (24-365): 5.96e-44: 163: 18.83		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1031475 PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1174858 LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		516712 PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1116390 LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1316900 MK67I_HUMAN (93-358): 1.25e-39: 148: 19.42		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1268179 LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1344500 RBM28_HUMAN (40-343): 2.97e-23: 106: 13.84		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1162693 LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1077515 ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		403284 LA_HUMAN (24-365): 5.96e-44: 163: 18.83		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1174819 LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1236478 MK67I_HUMAN (93-358): 1.25e-39: 148: 19.42		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1236408 LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Mm
		857360 TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94		SIR2_MOUSE (75-380): 2.24e-101: 307: 21.55
+	Hs
		1236530 RBM28_HUMAN (40-343): 2.97e-23: 106: 13.84		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1289417 MK67I_HUMAN (93-358): 1.25e-39: 148: 19.42		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94
+	Hs
		1162609 LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1077447 ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94