HitPredict

Interactor 1: BACD2 (Q13829)
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) (BTB/POZ domain-containing protein TNFAIP1) (Protein B12) (Tumor necrosis factor, alpha-induced protein 1, endothelial)
Gene: TNFAIP1

Interactor 2: BACD3 (Q9H3F6)
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (hBACURD3) (BTB/POZ domain-containing protein KCTD10) (Potassium channel tetramerization domain-containing protein 10)
Gene: KCTD10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.967

The method score is based on:

Property Details
Experiments 26186194, 28514442, 32296183, 32327643, 33961781, 22810651, unassigned1304
Identification Methods affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains BTB_2~BTB_2
Common GO terms GO:0005829 - cytosol
GO:0016567 - protein ubiquitination
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:0035024 - negative regulation of Rho protein signal transduction
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
and 1 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 316
Hs

1 313
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Last updated: 11Aug2025