Protein: KCTD2
BTB/POZ domain-containing protein KCTD2 (Potassium channel tetramerization domain-containing protein 2)

Gene: KCTD2
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q14681

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044877 - protein-containing complex binding
GO:0051260 - protein homooligomerization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1113115

CUL3
Cullin-3

8

20

Small-scale

0.967

High

1130012

KCD17
BTB/POZ domain-containing protein KCTD17

5

15

Small-scale

0.919

High

1130029

KCND2
A-type voltage-gated potassium channel KCND2

2

15

High-throughput

0.811

High

1130011

ARRD1
Arrestin domain-containing protein 1

4

5

High-throughput

0.691

High

983484

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

2

14

Small-scale

0.624

High

275840

GLRA3
Glycine receptor subunit alpha-3

2

5

High-throughput

0.621

High

1130003

KCTD2
BTB/POZ domain-containing protein KCTD2

1

14

Small-scale

0.618

High

1130028

KCTD5
BTB/POZ domain-containing protein KCTD5

1

15

Small-scale

0.618

High

1130008

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

20

High-throughput

0.611

High

1130009

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

7

High-throughput

0.611

High

890652

RGS3
Regulator of G-protein signaling 3

3

10

High-throughput

0.604

High

1130006

KLH12
Kelch-like protein 12

1

3

High-throughput

0.575

High

1130018

REPI1
DNA-binding protein REPIN1

2

2

High-throughput

0.574

High

948063

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

2

12

Small-scale

0.558

High

1130005

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

20

High-throughput

0.549

High

1130034

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

2

12

High-throughput

0.549

High

162832

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

20

High-throughput

0.536

High

220164

TNF14
Tumor necrosis factor ligand superfamily member 14

1

1

High-throughput

0.536

High

1130015

CNRP1
CB1 cannabinoid receptor-interacting protein 1

1

1

High-throughput

0.536

High

658521

GLRA2
Glycine receptor subunit alpha-2

1

5

High-throughput

0.489

High

1031997

TFAP4
Transcription factor AP-4

1

1

High-throughput

0.489

High

1130004

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

High-throughput

0.489

High

1130013

DLG3
Disks large homolog 3

1

10

High-throughput

0.489

High

1130027

TM45A
Transmembrane protein 45A

1

2

High-throughput

0.489

High

257460

PAGE4
P antigen family member 4

1

2

High-throughput

0.479

High

319766

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

372034

MYC
Myc proto-oncogene protein

1

1

Small-scale

0.479

High

396116

ESR1
Estrogen receptor

1

9

High-throughput

0.479

High

447017

NPM
Nucleophosmin

1

3

High-throughput

0.479

High

482477

F16P1
Fructose-1,6-bisphosphatase 1

1

2

High-throughput

0.479

High

603982

CXA1
Gap junction alpha-1 protein

1

6

Small-scale

0.479

High

970504

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

984115

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

14

Small-scale

0.479

High

1051231

KPCZ
Protein kinase C zeta type

1

11

High-throughput

0.479

High

1130010

VRK3
Serine/threonine-protein kinase VRK3

1

12

High-throughput

0.479

High

1130014

FBXW7
F-box/WD repeat-containing protein 7

1

4

Small-scale

0.479

High

1130016

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

1130020

TRIM6
Tripartite motif-containing protein 6

1

2

Small-scale

0.479

High

1130021

DDX24
ATP-dependent RNA helicase DDX24

1

6

High-throughput

0.479

High

1130024

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

14

Small-scale

0.479

High

1130032

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1130033

XPO7
Exportin-7

1

11

High-throughput

0.479

High

1130031

POLK
DNA polymerase kappa

1

2

High-throughput

0.470

High

1130019

GTPB4
GTP-binding protein 4

1

0

High-throughput

0.458

High

243470

GBG7

1

12

Small-scale

0.437

High

957380

UBC12
NEDD8-conjugating enzyme Ubc12

1

7

High-throughput

0.437

High

1092127

NFX1
Transcriptional repressor NF-X1

1

6

High-throughput

0.437

High

1130017

SNX27
Sorting nexin-27

1

20

High-throughput

0.437

High

1130025

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.437

High

1130030

GBG12

1

12

Small-scale

0.437

High

1130035

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.437

High

827784

STAT3
Signal transducer and activator of transcription 3

1

0

High-throughput

0.426

High

71055

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

20

High-throughput

0.407

High

548016

PSPC
Surfactant protein C

1

2

High-throughput

0.407

High

844774

EAA1
Excitatory amino acid transporter 1

1

5

High-throughput

0.407

High

1130007

T255A
Transmembrane protein 255A

3

0

High-throughput

0.347

High

1130022

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.279

Low

1130026

ZN331
Zinc finger protein 331

1

0

High-throughput

0.279

Low

1130023

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025