HitPredict

Interactor 1: ACTBL (Q562R1)
Beta-actin-like protein 2 (Kappa-actin)
Gene: ACTBL2

Interactor 2: TWF2 (Q6IBS0)
Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein)
Gene: TWF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005884 - actin filament GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 376 Hs			1 349
+	Hs
		891834 ACTB_HUMAN (3-376): 0: 596: 91.71		TWF2_HUMAN (1-349): 1.13e-170: 480: 100.00
+	Hs
		891728 ACTB_HUMAN (3-376): 0: 596: 91.71		TWF1_HUMAN (1-344): 4.14e-154: 438: 65.41
+	Dm
		501533 ACT1_DROME (1-376): 0: 599: 90.69		TWF_DROME (1-345): 1.83e-144: 413: 49.57
+	Ce
		501473 ACT4_CAEEL (1-376): 0: 601: 90.16		ADF1_CAEEL (4-189): 3.24e-40: 142: 18.66
+	Hs
		891649 ACTB_HUMAN (3-376): 0: 596: 91.71		DEST_HUMAN (3-138): 2.92e-40: 141: 21.29
+	Hs
		891650 ACTB_HUMAN (3-376): 0: 596: 91.71		GMFB_HUMAN (178-312): 1.08e-40: 141: 22.14
+	Hs
		894665 Q1KLZ0_HUMAN (3-376): 0: 596: 91.71		DEST_HUMAN (3-138): 2.92e-40: 141: 21.29
+	Hs
		618104 ACTBL_HUMAN (1-376): 0: 616: 100.00		COF1_HUMAN (3-138): 3.06e-32: 120: 17.95
+	Dm
		501443 ACT5_DROME (1-376): 0: 598: 89.10		CADF_DROME (3-144): 1.41e-38: 136: 13.42
+	Dm
		799742 ACT6_DROME (1-376): 0: 596: 88.83		CADF_DROME (3-144): 1.41e-38: 136: 13.42
+	Dm
		501459 ACT5_DROME (1-376): 0: 598: 89.10		Q9VWR1_DROME (5-143): 2.39e-37: 132: 20.27
+	Dm
		950132 ACT6_DROME (1-376): 0: 596: 88.83		Q9VWR1_DROME (5-143): 2.39e-37: 132: 20.27
+	Hs
		1092828 Q1KLZ0_HUMAN (3-376): 0: 596: 91.71		Q549N0_HUMAN (3-138): 6.86e-35: 127: 21.80
+	Hs
		891817 ACTB_HUMAN (3-376): 0: 596: 91.71		Q549N0_HUMAN (3-138): 6.86e-35: 127: 21.80
+	Hs
		892124 ACTB_HUMAN (3-376): 0: 596: 91.71		COF2_HUMAN (3-138): 6.86e-35: 127: 21.80
+	Mm
		578583 ACTB_MOUSE (3-376): 0: 596: 91.71		COF1_MOUSE (3-138): 6.36e-33: 122: 18.59
+	Hs
		618038 ACTB_HUMAN (3-376): 0: 596: 91.71		COF1_HUMAN (3-138): 3.06e-32: 120: 17.95
+	Hs
		618096 Q1KLZ0_HUMAN (3-376): 0: 596: 91.71		COF1_HUMAN (3-138): 3.06e-32: 120: 17.95
+	Rn
		799735 ACTB_RAT (3-376): 0: 596: 91.71		COF1_RAT (3-138): 1.73e-32: 120: 17.95
+	Hs
		618049 ACTG_HUMAN (3-376): 0: 595: 91.44		COF1_HUMAN (3-138): 3.06e-32: 120: 17.95