Protein: GIT1
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)

Gene: GIT1
Organism: Homo sapiens
Interactions: 160
UniProt ID: Q9Y2X7

Gene Ontology (top 5):
GO:0001771 - immunological synapse formation
GO:0001957 - intramembranous ossification
GO:0005096 - GTPase activator activity
GO:0005739 - mitochondrion
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1121998

ARHG7
Rho guanine nucleotide exchange factor 7

14

20

Small-scale

0.983

High

878587

PAXI
Paxillin

9

13

Small-scale

0.968

High

1096525

PAK1
Serine/threonine-protein kinase PAK 1

7

15

Small-scale

0.960

High

1140210

ARHG6
Rho guanine nucleotide exchange factor 6

6

20

Small-scale

0.945

High

1122465

GIT2
ARF GTPase-activating protein GIT2

5

14

Small-scale

0.930

High

1097245

PAK2
Serine/threonine-protein kinase PAK 2

5

13

Small-scale

0.922

High

594148

NCK1
SH2/SH3 adapter protein NCK1

5

20

Small-scale

0.908

High

253999

LPXN
Leupaxin

4

14

Small-scale

0.896

High

222231

NCK2
Cytoplasmic protein NCK2

4

20

High-throughput

0.892

High

988054

GRB2
Growth factor receptor-bound protein 2

4

20

High-throughput

0.891

High

1095609

LIPA1
Liprin-alpha-1

3

8

Small-scale

0.883

High

1490983

GIT1
ARF GTPase-activating protein GIT1

3

14

Small-scale

0.873

High

1453536

SPN90
NCK-interacting protein with SH3 domain

3

1

High-throughput

0.855

High

955776

CDC42
Cell division control protein 42 homolog

3

20

Small-scale

0.834

High

669153

ARBK1
Beta-adrenergic receptor kinase 1

3

9

Small-scale

0.827

High

988845

RAC1
Ras-related C3 botulinum toxin substrate 1

3

20

Small-scale

0.827

High

992401

SKP1
S-phase kinase-associated protein 1

2

1

High-throughput

0.811

High

212742

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

2

15

Small-scale

0.806

High

276391

LIPA4
Liprin-alpha-4

2

7

Small-scale

0.786

High

1158810

KCC4
Calcium/calmodulin-dependent protein kinase type IV

3

10

High-throughput

0.779

High

969091

PRS8
26S proteasome regulatory subunit 8

2

0

High-throughput

0.770

High

619140

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

4

Small-scale

0.724

High

1406812

BARD1
BRCA1-associated RING domain protein 1

1

20

High-throughput

0.713

High

1402066

TRIB3
Tribbles homolog 3

1

8

High-throughput

0.698

High

1428596

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.698

High

625719

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.691

High

911440

IMA5
Importin subunit alpha-5

1

1

High-throughput

0.691

High

1448017

KLHL1
Kelch-like protein 1

1

4

High-throughput

0.691

High

1490741

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

13

High-throughput

0.691

High

271641

LIPA3
Liprin-alpha-3

1

7

Small-scale

0.680

High

276384

LIPA2
Liprin-alpha-2

1

8

Small-scale

0.680

High

1122378

SCRIB
Protein scribble homolog

4

13

Small-scale

0.678

High

1385726

ENTR1
Endosome-associated-trafficking regulator 1

3

2

Small-scale

0.674

High

1446563

MED4
Mediator of RNA polymerase II transcription subunit 4

3

2

High-throughput

0.667

High

921584

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

1

High-throughput

0.667

High

1461847

MAFF
Transcription factor MafF

3

1

High-throughput

0.667

High

1051087

FAK1
Focal adhesion kinase 1

3

20

Small-scale

0.664

High

193645

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

6

High-throughput

0.656

High

908878

NEK2
Serine/threonine-protein kinase Nek2

1

11

High-throughput

0.656

High

967053

1433G
14-3-3 protein gamma

3

20

High-throughput

0.650

High

1049935

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

1421279

KLHL4
Kelch-like protein 4

1

5

High-throughput

0.648

High

49179

POTB3
POTE ankyrin domain family member B3

2

15

High-throughput

0.637

High

261897

PFD1
Prefoldin subunit 1

4

1

High-throughput

0.637

High

219251

LTOR5
Ragulator complex protein LAMTOR5

2

1

High-throughput

0.632

High

427962

ICAM1
Intercellular adhesion molecule 1

2

9

High-throughput

0.628

High

1435639

SYNCI
Syncoilin

2

4

High-throughput

0.628

High

1450298

EXOC1
Exocyst complex component 1

2

3

High-throughput

0.628

High

720076

HMOX2
Heme oxygenase 2

2

1

High-throughput

0.620

High

833447

RGS2
Regulator of G-protein signaling 2

2

4

High-throughput

0.620

High

297119

PAK3
Serine/threonine-protein kinase PAK 3

1

13

Small-scale

0.618

High

522756

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

2

Small-scale

0.618

High

581384

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

659094

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

1

3

Small-scale

0.618

High

710586

EPHA2
Ephrin type-A receptor 2

1

16

Small-scale

0.618

High

710922

EPHB2
Ephrin type-B receptor 2

1

13

Small-scale

0.618

High

774827

ARBK2
G protein-coupled receptor kinase 3

1

8

Small-scale

0.618

High

831682

CCNF
Cyclin-F

1

7

High-throughput

0.618

High

953770

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

975335

ARF6
ADP-ribosylation factor 6

1

15

Small-scale

0.618

High

1014985

ARF1
ADP-ribosylation factor 1

1

14

Small-scale

0.618

High

1015925

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1243075

PKN3
Serine/threonine-protein kinase N3

1

12

High-throughput

0.618

High

1256190

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.618

High

1271063

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1380276

FBXW7
F-box/WD repeat-containing protein 7

1

8

High-throughput

0.618

High

1415517

RUSC1
AP-4 complex accessory subunit RUSC1

1

1

High-throughput

0.618

High

1462761

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

9

Small-scale

0.618

High

1490773

NINL
Ninein-like protein

1

6

High-throughput

0.618

High

1490984

NEMO
NF-kappa-B essential modulator

1

10

Small-scale

0.618

High

1450434

FBX28
F-box only protein 28

3

1

High-throughput

0.604

High

167539

TX1B3
Tax1-binding protein 3

2

20

High-throughput

0.601

High

1150507

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

20

High-throughput

0.601

High

1243409

TM154
Transmembrane protein 154

2

1

High-throughput

0.601

High

844116

HD
Huntingtin

1

5

High-throughput

0.586

High

1453569

TMOD4
Tropomodulin-4

2

5

High-throughput

0.574

High

1490985

PCLO
Protein piccolo

1

12

Small-scale

0.573

High

601512

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.553

High

1396663

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.553

High

1433592

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

1434288

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.553

High

1088630

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.552

High

1186197

INAVA
Innate immunity activator protein

2

1

High-throughput

0.549

High

155816

TXND9
Thioredoxin domain-containing protein 9

1

3

High-throughput

0.541

High

876744

HSP13
Heat shock 70 kDa protein 13

1

4

High-throughput

0.541

High

162875

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

20

High-throughput

0.536

High

211671

ZNHI1
Zinc finger HIT domain-containing protein 1

1

1

High-throughput

0.536

High

1216694

CROCC
Rootletin

1

7

High-throughput

0.536

High

1272013

CENPQ
Centromere protein Q

1

1

High-throughput

0.536

High

1325861

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

1383899

EFMT3
EEF1A lysine methyltransferase 3

1

5

High-throughput

0.536

High

1420269

UBXN6
UBX domain-containing protein 6

1

3

High-throughput

0.536

High

1434776

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.536

High

928240

HAP1
Huntingtin-associated protein 1

1

1

High-throughput

0.527

High

1240789

PMF1
Polyamine-modulated factor 1

1

0

High-throughput

0.518

High

133596

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.513

High

1153147

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

2

High-throughput

0.508

High

928595

TERF1
Telomeric repeat-binding factor 1

1

4

High-throughput

0.494

High

1421333

WDR33
pre-mRNA 3' end processing protein WDR33

1

10

High-throughput

0.494

High

503683

TFPT
TCF3 fusion partner

1

1

High-throughput

0.489

High

1433810

SENP3
Sentrin-specific protease 3

1

1

High-throughput

0.489

High

1259042

CENPU
Centromere protein U

1

0

High-throughput

0.486

High

1454603

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.484

High

941308

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.481

High

177133

ERC2
ERC protein 2

1

5

Small-scale

0.479

High

243349

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

346533

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

11

High-throughput

0.479

High

365498

PGK1
Phosphoglycerate kinase 1

1

1

Small-scale

0.479

High

412855

NTRK1
High affinity nerve growth factor receptor

1

19

High-throughput

0.479

High

590085

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

696923

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

922088

COPA
Coatomer subunit alpha

1

4

Small-scale

0.479

High

1090206

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

11

Small-scale

0.479

High

1106759

SMAD4
Mothers against decapentaplegic homolog 4

1

8

High-throughput

0.479

High

1125306

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.479

High

1133065

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

3

High-throughput

0.479

High

1138787

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1156628

CCDC6
Coiled-coil domain-containing protein 6

1

5

High-throughput

0.479

High

1247052

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1252423

MEX3B
RNA-binding protein MEX3B

1

1

High-throughput

0.479

High

1277003

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

1316735

R113B
RING finger protein 113B

1

2

High-throughput

0.479

High

1329961

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

High-throughput

0.479

High

1336909

PSD4
PH and SEC7 domain-containing protein 4

1

7

High-throughput

0.479

High

1385452

SYTL4
Synaptotagmin-like protein 4

1

2

High-throughput

0.479

High

1396872

SNX27
Sorting nexin-27

1

20

High-throughput

0.479

High

1411393

LZTS2
Leucine zipper putative tumor suppressor 2

1

16

High-throughput

0.479

High

1419337

TRI55
Tripartite motif-containing protein 55

1

16

High-throughput

0.479

High

1421118

GRIP2
Glutamate receptor-interacting protein 2

1

20

Small-scale

0.479

High

1439073

NCK5L
Nck-associated protein 5-like

1

3

High-throughput

0.479

High

1460586

HOOK1
Protein Hook homolog 1

1

4

High-throughput

0.479

High

1462317

SNX6
Sorting nexin-6

1

3

Small-scale

0.479

High

165438

PSA7
Proteasome subunit alpha type-7

1

0

High-throughput

0.458

High

898548

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.458

High

1316492

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

1394373

HPDL
4-hydroxyphenylpyruvate dioxygenase-like protein

1

0

High-throughput

0.458

High

1103037

CENPR
Centromere protein R

1

1

High-throughput

0.457

High

1428225

NDEL1
Nuclear distribution protein nudE-like 1

1

8

High-throughput

0.457

High

1448585

DISC1
Disrupted in schizophrenia 1 protein

1

5

High-throughput

0.457

High

530630

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.445

High

691565

1433T
14-3-3 protein theta

1

20

High-throughput

0.445

High

730383

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.445

High

1402931

CK5P2
CDK5 regulatory subunit-associated protein 2

1

9

High-throughput

0.445

High

64443

BDP1
Transcription factor TFIIIB component B'' homolog

1

14

High-throughput

0.437

High

106896

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

769570

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1368219

HDAC2
Histone deacetylase 2

1

7

High-throughput

0.437

High

1383721

VP33A
Vacuolar protein sorting-associated protein 33A

1

4

High-throughput

0.437

High

947083

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

330377

VENTX
Homeobox protein VENTX

1

3

High-throughput

0.407

High

1258628

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.407

High

1435745

CH033
UPF0488 protein C8orf33

2

0

High-throughput

0.323

High

1212485

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.288

High

885520

MA2A2
Alpha-mannosidase 2x

1

0

High-throughput

0.282

High

1417214

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.282

High

1430156

CF263
Cilia- and flagella-associated protein 263

1

0

High-throughput

0.282

High

1415756

FND11
Fibronectin type III domain-containing protein 11

1

0

High-throughput

0.279

Low

1308122

AT2L2
5-phosphohydroxy-L-lysine phospho-lyase

1

0

High-throughput

0.269

Low

1272147

BEND5
BEN domain-containing protein 5

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025