HitPredict

Interactor 1: SMC1A (Q14683)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Gene: SMC1A

Interactor 2: WNK2 (Q9Y3S1)
Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43)
Gene: WNK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1233 Hs			1 2297
+	Hs
		1110443 SMC1A_HUMAN (1-1233): 1.05e-127: 425: 100.00		KCC2D_HUMAN (187-552): 1.2e-103: 344: 24.01
+	Hs
		1110592 SMC3_HUMAN (3-1229): 5.78e-69: 255: 15.78		KCC2D_HUMAN (187-552): 1.2e-103: 344: 24.01
+	Hs
		1130198 SMC1A_HUMAN (1-1233): 1.05e-127: 425: 100.00		NRBP2_HUMAN (192-455): 3.11e-26: 117: 30.50
+	Hs
		1130191 SMC1A_HUMAN (1-1233): 1.05e-127: 425: 100.00		NEK6_HUMAN (197-444): 3.21e-23: 104: 32.83
+	Hs
		1130118 SMC1A_HUMAN (1-1233): 1.05e-127: 425: 100.00		NEK7_HUMAN (195-444): 1.91e-22: 102: 29.62
+	Hs
		334105 SMC2_HUMAN (3-1214): 4.82e-78: 283: 18.14		NEK6_HUMAN (197-444): 3.21e-23: 104: 32.83
+	Hs
		1351885 SMC4_HUMAN (4-1216): 4.66e-77: 281: 20.21		NEK7_HUMAN (195-444): 1.91e-22: 102: 29.62
+	Hs
		1438797 SMC3_HUMAN (3-1229): 5.78e-69: 255: 15.78		NEK6_HUMAN (197-444): 3.21e-23: 104: 32.83