HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20876399
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 1025
+	Mm
		956463 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		MPRIP_MOUSE (1-1024): 9.38e-118: 388: 88.01
+	Hs
		148910 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		724862 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		1130714 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		MYH2_HUMAN (122-873): 5.69e-17: 89: 9.31
+	Hs
		254486 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		ROCK2_HUMAN (446-1018): 6.09e-17: 88.7: 11.81
+	Hs
		1130576 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		SLK_HUMAN (178-999): 9.15e-17: 87.8: 10.02
+	Hs
		725175 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		MYH10_HUMAN (534-1014): 3.94e-16: 85.9: 9.18
+	Hs
		1068556 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96
+	Hs
		1130255 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89
+	Mm
		1130117 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		MYH9_MOUSE (542-1025): 4.68e-18: 92.5: 8.68
+	Mm
		1130137 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		PLEC_MOUSE (494-979): 2.14e-11: 70.8: 14.60
+	Hs
		1357768 MFHA1_HUMAN (838-1119): 1.5e-30: 134: 16.95		CE164_HUMAN (163-980): 5.02e-36: 150: 11.93