Protein: NEK6
Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512)

Gene: NEK6
Organism: Homo sapiens
Interactions: 195
UniProt ID: Q9HC98

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0000922 - spindle pole
GO:0001222 - transcription corepressor binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1350569

NEK9
Serine/threonine-protein kinase Nek9

8

19

Small-scale

0.974

High

1351881

NEK7
Serine/threonine-protein kinase Nek7

6

16

High-throughput

0.950

High

1438794

IKZF3
Zinc finger protein Aiolos

5

7

High-throughput

0.925

High

1279979

NECA2
N-terminal EF-hand calcium-binding protein 2

5

0

High-throughput

0.879

High

1022795

XIAP
E3 ubiquitin-protein ligase XIAP

2

8

High-throughput

0.811

High

505771

ZN688
Zinc finger protein 688

2

5

High-throughput

0.783

High

600382

ZNF24
Zinc finger protein 24

2

7

High-throughput

0.783

High

1234964

PKHA7
Pleckstrin homology domain-containing family A member 7

2

20

High-throughput

0.783

High

1239210

ZN774
Zinc finger protein 774

2

4

High-throughput

0.783

High

1240821

ZN343
Zinc finger protein 343

2

6

High-throughput

0.783

High

1337271

GLIS3
Zinc finger protein GLIS3

2

11

High-throughput

0.783

High

1353573

ZFP90
Zinc finger protein 90 homolog

2

4

High-throughput

0.783

High

1394038

PP16A
Protein phosphatase 1 regulatory subunit 16A

2

2

High-throughput

0.783

High

1402949

ZN587
Zinc finger protein 587

2

4

High-throughput

0.783

High

1438782

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

8

High-throughput

0.783

High

1438786

RBAK
RB-associated KRAB zinc finger protein

2

2

High-throughput

0.783

High

1060809

ACK1
Activated CDC42 kinase 1

1

20

High-throughput

0.740

High

1104681

IKZF1
DNA-binding protein Ikaros

1

5

High-throughput

0.740

High

587222

ITF2
Transcription factor 4

4

3

High-throughput

0.705

High

1438781

PAK6
Serine/threonine-protein kinase PAK 6

1

16

High-throughput

0.698

High

1218959

TASO2
Protein TASOR 2

4

9

High-throughput

0.698

High

1228814

ANKS6
Ankyrin repeat and SAM domain-containing protein 6

1

5

High-throughput

0.691

High

1257209

ANKS3
Ankyrin repeat and SAM domain-containing protein 3

1

13

High-throughput

0.691

High

955620

CDC42
Cell division control protein 42 homolog

1

13

Small-scale

0.680

High

1437024

ANRA2
Ankyrin repeat family A protein 2

1

10

Small-scale

0.680

High

1081487

INCA1
Protein INCA1

4

0

High-throughput

0.675

High

572227

TRI27
Zinc finger protein RFP

3

8

High-throughput

0.675

High

1146172

K1H1
Keratin, type I cuticular Ha1

3

7

High-throughput

0.675

High

1230271

K1C40
Keratin, type I cytoskeletal 40

3

5

High-throughput

0.675

High

1409645

DHB14
L-fucose dehydrogenase

3

1

High-throughput

0.675

High

1411313

LZTS2
Leucine zipper putative tumor suppressor 2

3

20

High-throughput

0.675

High

1158553

CDC37
Hsp90 co-chaperone Cdc37

1

12

High-throughput

0.665

High

908175

KS6A3
Ribosomal protein S6 kinase alpha-3

1

16

High-throughput

0.665

High

1438780

NEK6
Serine/threonine-protein kinase Nek6

1

17

Small-scale

0.647

High

1061883

TLE5
TLE family member 5

3

0

High-throughput

0.646

High

1142266

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

High-throughput

0.630

High

783422

TRI23
E3 ubiquitin-protein ligase TRIM23

2

4

High-throughput

0.628

High

991719

DYL1
Dynein light chain 1, cytoplasmic

2

12

High-throughput

0.621

High

1181502

EMAL3
Echinoderm microtubule-associated protein-like 3

2

12

High-throughput

0.621

High

1437873

PRD16
Histone-lysine N-methyltransferase PRDM16

1

4

High-throughput

0.621

High

658933

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

3

Small-scale

0.619

High

182783

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.618

High

719038

WEE1
Wee1-like protein kinase

1

17

High-throughput

0.618

High

920285

PLK1
Serine/threonine-protein kinase PLK1

1

17

High-throughput

0.618

High

1438579

EMAL4
Echinoderm microtubule-associated protein-like 4

2

10

Small-scale

0.611

High

221432

SPY3
Protein sprouty homolog 3

2

2

High-throughput

0.606

High

250343

VINEX
Vinexin

2

16

High-throughput

0.606

High

281423

GGYF1
GRB10-interacting GYF protein 1

2

4

High-throughput

0.606

High

300499

KRT34
Keratin, type I cuticular Ha4

2

5

High-throughput

0.606

High

341862

K2C75
Keratin, type II cytoskeletal 75

2

2

High-throughput

0.606

High

437350

K2C8
Keratin, type II cytoskeletal 8

2

3

High-throughput

0.606

High

451274

NFL
Neurofilament light polypeptide

2

15

High-throughput

0.606

High

570603

GFAP
Glial fibrillary acidic protein

2

15

High-throughput

0.606

High

581794

MYOG
Myogenin

2

3

High-throughput

0.606

High

605028

HXB6
Homeobox protein Hox-B6

2

4

High-throughput

0.606

High

606163

DESM
Desmin

2

15

High-throughput

0.606

High

885423

HXA1
Homeobox protein Hox-A1

2

8

High-throughput

0.606

High

941570

CTBP2
C-terminal-binding protein 2

2

3

High-throughput

0.606

High

950691

KR108
Keratin-associated protein 10-8

2

4

High-throughput

0.606

High

1090932

TRAF2
TNF receptor-associated factor 2

2

14

High-throughput

0.606

High

1163762

PTN21
Tyrosine-protein phosphatase non-receptor type 21

2

14

High-throughput

0.606

High

1187755

KR133
Keratin-associated protein 13-3

2

2

High-throughput

0.606

High

1216158

FHL5
Four and a half LIM domains protein 5

2

2

High-throughput

0.606

High

1278740

ZN438
Zinc finger protein 438

2

7

High-throughput

0.606

High

1325601

ZCHC7
Zinc finger CCHC domain-containing protein 7

2

1

High-throughput

0.606

High

1347461

CEP76
Centrosomal protein of 76 kDa

2

1

High-throughput

0.606

High

1352428

SH3R2
E3 ubiquitin-protein ligase SH3RF2

2

13

High-throughput

0.606

High

1359988

MB3L1
Methyl-CpG-binding domain protein 3-like 1

2

1

High-throughput

0.606

High

1386883

DDT4L
DNA damage-inducible transcript 4-like protein

2

3

High-throughput

0.606

High

1388864

HOOK2
Protein Hook homolog 2

2

20

High-throughput

0.606

High

1403945

HTF4
Transcription factor 12

2

3

High-throughput

0.606

High

1411224

TIRR
Tudor-interacting repair regulator protein

2

1

High-throughput

0.606

High

1419233

TRI54
Tripartite motif-containing protein 54

2

20

High-throughput

0.606

High

1429532

KTBL1
KATNB1-like protein 1

2

1

High-throughput

0.606

High

1438783

PICK1
PRKCA-binding protein

2

5

High-throughput

0.606

High

1438789

TFP11
Tuftelin-interacting protein 11

2

2

High-throughput

0.606

High

1438793

ZRAN1
Ubiquitin thioesterase ZRANB1

2

12

High-throughput

0.606

High

1438796

FOXJ3
Forkhead box protein J3

2

8

High-throughput

0.606

High

1438800

LZTS1
Leucine zipper putative tumor suppressor 1

2

20

High-throughput

0.606

High

1438802

GRIP1
Glutamate receptor-interacting protein 1

2

4

High-throughput

0.606

High

155031

BHE40
Class E basic helix-loop-helix protein 40

2

0

High-throughput

0.580

High

1200194

SMUG1
Single-strand selective monofunctional uracil DNA glycosylase

2

0

High-throughput

0.580

High

1211762

UBX11
UBX domain-containing protein 11

2

0

High-throughput

0.580

High

1278485

F220A
Protein FAM220A

2

0

High-throughput

0.580

High

1398718

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.580

High

1410482

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

2

0

High-throughput

0.580

High

1419194

PBX4
Pre-B-cell leukemia transcription factor 4

2

0

High-throughput

0.580

High

1428850

NIF3L
NIF3-like protein 1

2

0

High-throughput

0.580

High

1209681

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

15

High-throughput

0.575

High

1366250

LPAR1
Lysophosphatidic acid receptor 1

1

2

High-throughput

0.575

High

1391779

AURKB
Aurora kinase B

1

15

High-throughput

0.575

High

562410

LAMP2
Lysosome-associated membrane glycoprotein 2

2

4

High-throughput

0.574

High

1128954

I13R2
Interleukin-13 receptor subunit alpha-2

2

12

High-throughput

0.574

High

1438798

LAMP3
Lysosome-associated membrane glycoprotein 3

2

4

High-throughput

0.574

High

1030038

RELB
Transcription factor RelB

1

11

Small-scale

0.573

High

1348516

LNX1
E3 ubiquitin-protein ligase LNX

1

5

High-throughput

0.573

High

699474

PROP
Properdin

2

10

High-throughput

0.553

High

1206435

EFHC2
EF-hand domain-containing family member C2

2

4

High-throughput

0.553

High

636770

PTN
Pleiotrophin

1

1

Small-scale

0.549

High

1279906

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

7

Small-scale

0.549

High

1400900

PRAM
PML-RARA-regulated adapter molecule 1

1

8

Small-scale

0.549

High

882567

ARRB1
Beta-arrestin-1

1

5

High-throughput

0.541

High

1154597

CC85B
Coiled-coil domain-containing protein 85B

1

1

High-throughput

0.541

High

1438785

KCTD5
BTB/POZ domain-containing protein KCTD5

1

6

High-throughput

0.541

High

1310428

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

156405

RHG33
Rho GTPase-activating protein 33

1

5

Small-scale

0.527

High

716632

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

7

Small-scale

0.527

High

967565

RS7
Small ribosomal subunit protein eS7

1

1

Small-scale

0.527

High

1214491

ER6L2
DNA excision repair protein ERCC-6-like 2

1

4

Small-scale

0.527

High

617250

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.526

High

1151390

TRIP4
Activating signal cointegrator 1

1

0

Small-scale

0.526

High

123840

MYO1C
Unconventional myosin-Ic

1

20

High-throughput

0.515

High

348916

EMAL2
Echinoderm microtubule-associated protein-like 2

1

10

High-throughput

0.515

High

756358

MCM7
DNA replication licensing factor MCM7

1

4

High-throughput

0.515

High

841962

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.515

High

1098143

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

4

High-throughput

0.515

High

1109394

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.515

High

1153340

AAAT
Neutral amino acid transporter B(0)

1

3

High-throughput

0.515

High

1207341

PCID2
PCI domain-containing protein 2

1

4

High-throughput

0.515

High

1323162

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

High-throughput

0.515

High

1353371

IPO4
Importin-4

1

7

High-throughput

0.515

High

1371542

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

11

High-throughput

0.515

High

1437767

XPO5
Exportin-5

1

18

High-throughput

0.515

High

1438784

FANCI
Fanconi anemia group I protein

1

1

High-throughput

0.515

High

1438797

SMC3
Structural maintenance of chromosomes protein 3

1

16

High-throughput

0.515

High

1438799

RUVB2
RuvB-like 2

1

5

High-throughput

0.515

High

556358

CADH1
Cadherin-1

1

6

High-throughput

0.515

High

698031

CALR
Calreticulin

1

1

High-throughput

0.515

High

1232587

Q6FHY5
MEOX2 protein

1

7

High-throughput

0.515

High

1438792

RIM3A
RIMS-binding protein 3A

1

15

High-throughput

0.515

High

262314

SCN2B
Sodium channel regulatory subunit beta-2

1

2

High-throughput

0.514

High

466974

ACM4
Muscarinic acetylcholine receptor M4

1

1

High-throughput

0.514

High

1293912

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

2

High-throughput

0.514

High

388304

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

210351

PHF1
PHD finger protein 1

1

0

Small-scale

0.504

High

1293536

CIR1
Corepressor interacting with RBPJ 1

1

0

Small-scale

0.504

High

1323468

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.493

High

788212

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.493

High

183970

S22A2
Solute carrier family 22 member 2

1

1

High-throughput

0.489

High

275822

CAD16
Cadherin-16

1

9

High-throughput

0.489

High

1053071

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.489

High

1438788

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.489

High

66403

RIM3C
RIMS-binding protein 3C

1

16

High-throughput

0.481

High

894180

MEOX2
Homeobox protein MOX-2

1

7

High-throughput

0.481

High

1180436

PRIC4
Prickle-like protein 4

1

6

High-throughput

0.481

High

1307037

KR131
Keratin-associated protein 13-1

1

2

High-throughput

0.481

High

1311787

HOMEZ
Homeobox and leucine zipper protein Homez

1

3

High-throughput

0.481

High

334105

SMC2
Structural maintenance of chromosomes protein 2

1

12

High-throughput

0.479

High

337028

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

3

High-throughput

0.479

High

340941

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

11

High-throughput

0.479

High

467617

4F2
Amino acid transporter heavy chain SLC3A2

1

1

High-throughput

0.479

High

704991

RBL1
Retinoblastoma-like protein 1

1

1

High-throughput

0.479

High

857183

NSF
Vesicle-fusing ATPase

1

6

High-throughput

0.479

High

1130191

SMC1A
Structural maintenance of chromosomes protein 1A

1

16

High-throughput

0.479

High

1137272

CND1
Condensin complex subunit 1

1

1

High-throughput

0.479

High

1247899

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

2

High-throughput

0.479

High

1353106

ARH40
Rho guanine nucleotide exchange factor 40

1

4

High-throughput

0.479

High

1365763

GCN1
Stalled ribosome sensor GCN1

1

15

High-throughput

0.479

High

1420344

UCK2
Uridine-cytidine kinase 2

1

2

High-throughput

0.479

High

1438790

MYO1A
Unconventional myosin-Ia

1

14

High-throughput

0.479

High

1438791

COPG2
Coatomer subunit gamma-2

1

4

High-throughput

0.479

High

1438803

TNPO3
Transportin-3

1

19

High-throughput

0.479

High

665014

ERD21
ER lumen protein-retaining receptor 1

1

2

High-throughput

0.470

High

1438787

HACD3
Very-long-chain

1

4

High-throughput

0.470

High

1332285

GG6L2
Golgin subfamily A member 6-like protein 2

1

19

High-throughput

0.470

High

184518

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.458

High

1293747

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.458

High

1294733

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.458

High

1429352

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

475002

VIME
Vimentin

1

16

High-throughput

0.457

High

1049007

REL
Proto-oncogene c-Rel

1

13

High-throughput

0.457

High

1227495

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.445

High

1400778

MYCT
Proton myo-inositol cotransporter

1

2

High-throughput

0.445

High

1434746

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.445

High

1395352

CC136
Coiled-coil domain-containing protein 136

1

20

High-throughput

0.439

High

887238

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

260964

RAMP3
Receptor activity-modifying protein 3

1

1

High-throughput

0.407

High

628464

KLK2
Kallikrein-2

1

5

High-throughput

0.407

High

844971

EAA2
Excitatory amino acid transporter 2

1

3

High-throughput

0.407

High

1438795

PCDGG
Protocadherin gamma-B4

1

5

High-throughput

0.407

High

1314612

IHO1
Interactor of HORMAD1 protein 1

3

0

High-throughput

0.352

High

66301

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

2

0

High-throughput

0.316

High

1198855

ZC21C
Zinc finger C2HC domain-containing protein 1C

2

0

High-throughput

0.316

High

1287061

K1328
Protein hinderin

2

0

High-throughput

0.316

High

1315746

SAXO1
Stabilizer of axonemal microtubules 1

2

0

High-throughput

0.316

High

1330687

BEND7
BEN domain-containing protein 7

2

0

High-throughput

0.316

High

1332440

CBY2
Protein chibby homolog 2

2

0

High-throughput

0.316

High

1332465

SAXO5
Stabilizer of axonemal microtubules 5

2

0

High-throughput

0.316

High

1350974

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

1392996

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.316

High

1438801

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.316

High

1391514

BSCL2
Seipin

1

0

High-throughput

0.279

Low

1438756

Q9HC85
Metastasis related protein

1

0

High-throughput

0.249

Low

1185901

TMM95
Sperm-egg fusion protein TMEM95

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025