HitPredict

Interactor 1: Q60I23 (Q60I23)
SRY (sex determining region Y)-box 2 (Sox2 protein) (Transcriptional factor SOX2)
Gene: Sox2

Interactor 2: NANOG (Q80Z64)
Homeobox protein NANOG (ES cell-associated protein 4) (Early embryo specific expression NK-type homeobox protein) (Homeobox transcription factor Nanog)
Gene: NANOG

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	23892456
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001714 - endodermal cell fate specification GO:0005654 - nucleoplasm GO:0035019 - somatic stem cell population maintenance and 1 others more... GO:0042246 - tissue regeneration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 319 Mm			1 305
+	Mm
		818733 SOX2_MOUSE (1-319): 1.13e-62: 203: 98.43		NANOG_MOUSE (1-305): 9.78e-60: 194: 100.00
+	Hs
		818476 SOX2_HUMAN (1-319): 1.7e-62: 202: 96.24		NANOG_HUMAN (1-302): 7.54e-43: 150: 53.72
+	Hs
		818455 SOX2_HUMAN (1-319): 1.7e-62: 202: 96.24		ALX4_HUMAN (11-277): 4.64e-35: 132: 12.73
+	Mm
		192289 SOX2_MOUSE (1-319): 1.13e-62: 203: 98.43		ALX4_MOUSE (11-277): 2.76e-34: 130: 12.36
+	Mm
		818775 SOX2_MOUSE (1-319): 1.13e-62: 203: 98.43		Q9QX99_MOUSE (29-215): 7.4e-34: 128: 22.80
+	Hs
		817906 SOX2_HUMAN (1-319): 1.7e-62: 202: 96.24		PITX1_HUMAN (35-289): 2.68e-34: 128: 15.88
+	Mm
		818723 SOX2_MOUSE (1-319): 1.13e-62: 203: 98.43		DLX1_MOUSE (1-207): 4.45e-34: 126: 26.05
+	Mm
		818684 SOX2_MOUSE (1-319): 1.13e-62: 203: 98.43		PAX6_MOUSE (37-288): 5.3e-30: 119: 15.69
+	Hs
		641335 SOX2_HUMAN (1-319): 1.7e-62: 202: 96.24		PAX6_HUMAN (37-288): 5.3e-30: 119: 15.69
+	Xl
		193808 SOX2_XENLA (1-319): 8.4e-61: 198: 85.89		OTX2A_XENLA (61-286): 9.41e-31: 118: 18.97
+	Hs
		174009 SOX5_HUMAN (17-129): 1.06e-39: 150: 40.71		SHOX_HUMAN (75-155): 1.94e-32: 123: 30.86
+	Hs
		620192 CIC_HUMAN (10-274): 1.46e-36: 141: 24.28		PAX7_HUMAN (79-299): 1.61e-33: 130: 16.81
+	Hs
		641331 SOX5_HUMAN (17-129): 1.06e-39: 150: 40.71		PAX6_HUMAN (37-288): 5.3e-30: 119: 15.69
+	Hs
		679158 CIC_HUMAN (10-274): 1.46e-36: 141: 24.28		TLX1_HUMAN (29-215): 3.58e-34: 128: 22.80
+	Hs
		724175 SOX5_HUMAN (17-129): 1.06e-39: 150: 40.71		MSX2_HUMAN (18-193): 2.88e-31: 119: 25.68
+	Hs
		620250 CIC_HUMAN (10-274): 1.46e-36: 141: 24.28		PAX3_HUMAN (70-257): 1.43e-30: 121: 18.04
+	Hs
		839810 CIC_HUMAN (10-274): 1.46e-36: 141: 24.28		LHX2_HUMAN (8-232): 1.48e-30: 120: 15.49
+	Hs
		641534 CIC_HUMAN (10-274): 1.46e-36: 141: 24.28		PAX6_HUMAN (37-288): 5.3e-30: 119: 15.69
+	Hs
		213372 CIC_HUMAN (10-274): 1.46e-36: 141: 24.28		TLX2_HUMAN (60-158): 3.78e-27: 108: 30.39
+	Hs
		211942 CIC_HUMAN (10-274): 1.46e-36: 141: 24.28		TLX3_HUMAN (89-153): 9.32e-09: 57.4: 43.08