Protein: GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)

Gene: GAPD1, GAPVD1
Organism: Homo sapiens
Interactions: 121
UniProt ID: Q14C86

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005768 - endosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

876857

KC1A
Casein kinase I isoform alpha

7

8

High-throughput

0.747

High

729847

1433B
14-3-3 protein beta/alpha

7

20

High-throughput

0.745

High

885779

KC1E
Casein kinase I isoform epsilon

6

20

High-throughput

0.738

High

877115

KC1D
Casein kinase I isoform delta

6

14

High-throughput

0.734

High

966325

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

1049301

1433F
14-3-3 protein eta

3

20

High-throughput

0.667

High

241708

PRKN
E3 ubiquitin-protein ligase parkin

3

9

High-throughput

0.640

High

641175

FGFR2
Fibroblast growth factor receptor 2

2

20

High-throughput

0.628

High

1135426

RAB35
Ras-related protein Rab-35

1

16

High-throughput

0.618

High

990238

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

1135442

MICU2
Calcium uptake protein 2, mitochondrial

3

12

High-throughput

0.609

High

1135464

TSSK1
Testis-specific serine/threonine-protein kinase 1

3

9

High-throughput

0.609

High

1135441

FBX11
F-box only protein 11

2

1

High-throughput

0.601

High

170142

AURKA
Aurora kinase A

2

9

High-throughput

0.584

High

919972

PLK1
Serine/threonine-protein kinase PLK1

2

7

High-throughput

0.584

High

1135482

SNX24
Sorting nexin-24

2

1

High-throughput

0.574

High

1135445

KC1AL
Casein kinase I isoform alpha-like

2

14

High-throughput

0.558

High

415576

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.541

High

176197

PER2
Period circadian protein homolog 2

1

4

High-throughput

0.536

High

181112

AXIN1
Axin-1

1

3

High-throughput

0.536

High

347031

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

659479

CRCM
Colorectal mutant cancer protein

1

8

High-throughput

0.536

High

930891

HSP72
Heat shock-related 70 kDa protein 2

1

12

High-throughput

0.536

High

971539

1433E
14-3-3 protein epsilon

1

11

High-throughput

0.536

High

1135448

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

6

High-throughput

0.536

High

1135458

EFMT3
EEF1A lysine methyltransferase 3

1

6

High-throughput

0.536

High

1135479

DS13B
Dual specificity protein phosphatase 13B

2

3

High-throughput

0.533

High

642878

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

5

High-throughput

0.515

High

1135454

THRSP
Thyroid hormone-inducible hepatic protein

1

0

High-throughput

0.513

High

913651

VAV2
Guanine nucleotide exchange factor VAV2

1

14

High-throughput

0.508

High

1091048

FOXF1
Forkhead box protein F1

1

6

High-throughput

0.489

High

1091284

FOXL1
Forkhead box protein L1

1

6

High-throughput

0.489

High

1135449

F110D
Protein FAM110D

1

2

High-throughput

0.489

High

1135462

NPAS1
Neuronal PAS domain-containing protein 1

1

5

High-throughput

0.489

High

1135463

FOXB1
Forkhead box protein B1

1

6

High-throughput

0.489

High

58724

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

4

High-throughput

0.479

High

172824

XPO1
Exportin-1

1

5

High-throughput

0.479

High

218193

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

243940

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

9

High-throughput

0.479

High

345836

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

411948

NTRK1
High affinity nerve growth factor receptor

1

19

High-throughput

0.479

High

487331

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.479

High

556087

CADH1
Cadherin-1

1

10

High-throughput

0.479

High

623347

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

High-throughput

0.479

High

651331

CBL
E3 ubiquitin-protein ligase CBL

1

9

Small-scale

0.479

High

730594

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

731306

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

799125

BRCA1
Breast cancer type 1 susceptibility protein

1

8

High-throughput

0.479

High

830753

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

862143

YAP1
Transcriptional coactivator YAP1

1

15

High-throughput

0.479

High

888074

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

891166

GSK3A
Glycogen synthase kinase-3 alpha

1

15

High-throughput

0.479

High

891558

GSK3B
Glycogen synthase kinase-3 beta

1

17

High-throughput

0.479

High

970516

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

995599

ACTC
Actin, alpha cardiac muscle 1

1

12

High-throughput

0.479

High

1067343

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

1101458

KCAB2
Voltage-gated potassium channel subunit beta-2

1

1

High-throughput

0.479

High

1106880

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

1107727

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1109734

HDAC1
Histone deacetylase 1

1

4

High-throughput

0.479

High

1113133

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1128198

MCM6
DNA replication licensing factor MCM6

1

4

High-throughput

0.479

High

1135424

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

1135425

EEA1
Early endosome antigen 1

1

12

High-throughput

0.479

High

1135430

RN123
E3 ubiquitin-protein ligase RNF123

1

6

High-throughput

0.479

High

1135432

RNF43
E3 ubiquitin-protein ligase RNF43

1

5

High-throughput

0.479

High

1135434

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

1135446

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

1135447

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1135452

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

6

High-throughput

0.479

High

1135455

GOGA1
Golgin subfamily A member 1

1

8

High-throughput

0.479

High

1135461

RUFY1
RUN and FYVE domain-containing protein 1

1

14

High-throughput

0.479

High

1135466

WWTR1
WW domain-containing transcription regulator protein 1

1

12

High-throughput

0.479

High

1135467

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.479

High

1135468

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.479

High

1135470

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1135473

DUS22
Dual specificity protein phosphatase 22

1

2

High-throughput

0.479

High

1135476

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.479

High

1135477

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

9

High-throughput

0.479

High

1135478

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1135484

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

5

High-throughput

0.479

High

1135485

NS1BP
Influenza virus NS1A-binding protein

1

4

High-throughput

0.479

High

238524

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

1026388

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1135438

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1135457

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

1135481

AGO2
Protein argonaute-2

1

0

Small-scale

0.458

High

964287

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.457

High

934622

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.445

High

1135427

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

1135450

CE192
Centrosomal protein of 192 kDa

1

1

High-throughput

0.445

High

1135465

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

1135471

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

1135474

S39A9
Zinc transporter ZIP9

1

4

High-throughput

0.445

High

105951

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

246607

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.437

High

571437

GLU2B
Glucosidase 2 subunit beta

1

2

High-throughput

0.437

High

755711

MCM4
DNA replication licensing factor MCM4

1

3

High-throughput

0.437

High

1004576

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

1135429

ZN618
Zinc finger protein 618

1

1

Small-scale

0.437

High

1135435

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.437

High

1135437

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

1135439

MGDP1
Magnesium-dependent phosphatase 1

1

1

High-throughput

0.437

High

1135440

HOOK3
Protein Hook homolog 3

1

12

High-throughput

0.437

High

1135444

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.437

High

1135451

DUS19
Dual specificity protein phosphatase 19

1

3

High-throughput

0.437

High

1135453

ESR2
Estrogen receptor beta

1

11

High-throughput

0.437

High

1135459

PF21A
PHD finger protein 21A

1

6

High-throughput

0.437

High

1135460

ARL5B
ADP-ribosylation factor-like protein 5B

1

13

High-throughput

0.437

High

1135472

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

6

High-throughput

0.437

High

1135433

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

1135469

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.426

High

62523

S35F4
Solute carrier family 35 member F4

1

2

High-throughput

0.407

High

1135436

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

5

High-throughput

0.407

High

1135443

SVOPL
Putative transporter SVOPL

1

1

High-throughput

0.407

High

1135428

SPT46
Spermatogenesis-associated protein 46

3

0

High-throughput

0.347

High

1135456

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.279

Low

1135475

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.279

Low

1135431

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1135480

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.249

Low

1135483

UFC1
Ubiquitin-fold modifier-conjugating enzyme 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025