Protein: RIN1
Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)

Gene: RIN1
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q13671

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005856 - cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

374583

RASH
GTPase HRas

12

18

Small-scale

0.983

High

967203

RRAS2
Ras-related protein R-Ras2

6

17

Small-scale

0.948

High

373918

RASN
GTPase NRas

6

18

High-throughput

0.942

High

520686

RRAS
Ras-related protein R-Ras

3

18

High-throughput

0.855

High

375499

RASK
GTPase KRas

2

19

High-throughput

0.811

High

631206

RAB5A
Ras-related protein Rab-5A

2

20

Small-scale

0.783

High

959439

RAP2B
Ras-related protein Rap-2b

2

10

High-throughput

0.776

High

840956

ABL2
Tyrosine-protein kinase ABL2

5

20

Small-scale

0.720

High

362285

ABL1
Tyrosine-protein kinase ABL1

5

20

Small-scale

0.714

High

971504

1433E
14-3-3 protein epsilon

5

6

Small-scale

0.711

High

1116691

LZTS2
Leucine zipper putative tumor suppressor 2

4

10

High-throughput

0.705

High

1116682

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

4

5

High-throughput

0.692

High

966293

1433G
14-3-3 protein gamma

4

20

High-throughput

0.691

High

1049273

1433F
14-3-3 protein eta

4

20

High-throughput

0.691

High

1116669

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

4

7

High-throughput

0.683

High

641595

ERBB3
Receptor tyrosine-protein kinase erbB-3

3

20

High-throughput

0.641

High

1095619

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

2

4

High-throughput

0.640

High

1116692

CCM2
Cerebral cavernous malformations 2 protein

3

0

High-throughput

0.636

High

363255

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.634

High

990201

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.628

High

936321

AFAD
Afadin

1

3

Small-scale

0.621

High

956573

RAB5B
Ras-related protein Rab-5B

1

20

Small-scale

0.621

High

1116648

RIN1
Ras and Rab interactor 1

1

11

High-throughput

0.618

High

296494

STAM2
Signal transducing adapter molecule 2

2

9

Small-scale

0.612

High

250244

VINEX
Vinexin

2

20

High-throughput

0.606

High

269196

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

300351

KRT34
Keratin, type I cuticular Ha4

2

5

High-throughput

0.606

High

571964

TRI27
Zinc finger protein RFP

2

10

High-throughput

0.606

High

783264

TRI23
E3 ubiquitin-protein ligase TRIM23

2

3

High-throughput

0.606

High

1090633

TRAF2
TNF receptor-associated factor 2

2

11

High-throughput

0.606

High

1116650

SNX17
Sorting nexin-17

2

1

High-throughput

0.606

High

1116653

CIP4
Cdc42-interacting protein 4

2

4

High-throughput

0.606

High

1116657

KR151
Keratin-associated protein 15-1

2

3

High-throughput

0.606

High

1116660

KLH12
Kelch-like protein 12

2

2

High-throughput

0.606

High

1116661

PKHG4
Puratrophin-1

2

4

High-throughput

0.606

High

1116668

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

2

3

High-throughput

0.606

High

1116671

TBCD1
TBC1 domain family member 1

2

1

High-throughput

0.606

High

1116686

CPNS2
Calpain small subunit 2

2

2

High-throughput

0.606

High

1116695

CAR10
Caspase recruitment domain-containing protein 10

2

3

High-throughput

0.606

High

1116697

TRIM7
E3 ubiquitin-protein ligase TRIM7

2

10

High-throughput

0.606

High

1116702

TFP11
Tuftelin-interacting protein 11

2

1

High-throughput

0.606

High

1116694

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

2

0

High-throughput

0.602

High

1091734

GNDS
Ral guanine nucleotide dissociation stimulator

1

0

Small-scale

0.589

High

1116708

NS1BP
Influenza virus NS1A-binding protein

2

5

High-throughput

0.584

High

729817

1433B
14-3-3 protein beta/alpha

2

20

Small-scale

0.583

High

131422

EIF3F
Eukaryotic translation initiation factor 3 subunit F

2

0

High-throughput

0.580

High

1116652

SC23B
Protein transport protein Sec23B

2

0

High-throughput

0.580

High

1116689

MDFI
MyoD family inhibitor

2

0

High-throughput

0.580

High

1116700

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

518598

RAP2A
Ras-related protein Rap-2a

1

14

High-throughput

0.575

High

959329

RAP1B
Ras-related protein Rap-1b

1

20

High-throughput

0.575

High

1032304

OTUD4
OTU domain-containing protein 4

2

1

High-throughput

0.571

High

1116676

SH2D3
SH2 domain-containing protein 3C

2

20

High-throughput

0.571

High

65040

GG6L9
Golgin subfamily A member 6-like protein 9

2

7

High-throughput

0.553

High

354223

ZBED1
E3 SUMO-protein ligase ZBED1

2

2

High-throughput

0.553

High

1063234

GOGA2
Golgin subfamily A member 2

2

3

High-throughput

0.553

High

1116675

EFC4A
EF-hand calcium-binding domain-containing protein 4A

2

8

High-throughput

0.553

High

1116699

HM20A
High mobility group protein 20A

2

4

High-throughput

0.553

High

1116687

MYCBP
c-Myc-binding protein

2

0

High-throughput

0.547

High

1116707

SPIN1
Spindlin-1

2

0

High-throughput

0.547

High

158437

RFXK
DNA-binding protein RFXANK

1

5

High-throughput

0.536

High

244848

TRAK2
Trafficking kinesin-binding protein 2

1

9

High-throughput

0.536

High

1116677

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

4

High-throughput

0.536

High

1116679

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

1

1

High-throughput

0.536

High

1116683

EFMT3
EEF1A lysine methyltransferase 3

1

5

High-throughput

0.536

High

1116685

KLH29
Kelch-like protein 29

1

2

High-throughput

0.536

High

1116696

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1116704

HSPB8
Heat shock protein beta-8

1

2

High-throughput

0.536

High

521677

H14
Histone H1.4

2

1

High-throughput

0.521

High

1023058

RBM10
RNA-binding protein 10

2

6

High-throughput

0.521

High

1116654

SMAD2
Mothers against decapentaplegic homolog 2

1

2

Small-scale

0.515

High

1116659

Q49AR9
ANKS1A protein

1

10

High-throughput

0.515

High

239058

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.513

High

298169

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.513

High

329924

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.513

High

636848

GSTM3
Glutathione S-transferase Mu 3

1

0

High-throughput

0.513

High

642225

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.513

High

1116656

INF2
Inverted formin-2

1

0

High-throughput

0.513

High

1116662

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.513

High

1116664

DPP8
Dipeptidyl peptidase 8

1

0

High-throughput

0.513

High

1116680

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.513

High

410827

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.501

High

690017

CRBB3
Beta-crystallin B3

1

1

High-throughput

0.489

High

1041750

PPARD
Peroxisome proliferator-activated receptor delta

1

1

High-throughput

0.489

High

1116674

KLH34
Kelch-like protein 34

1

8

High-throughput

0.489

High

1116688

NPAS1
Neuronal PAS domain-containing protein 1

1

5

High-throughput

0.489

High

1116698

DNAI2
Dynein axonemal intermediate chain 2

1

4

High-throughput

0.489

High

1116670

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

20

High-throughput

0.481

High

1116673

KR131
Keratin-associated protein 13-1

1

3

High-throughput

0.481

High

1116681

TSC1
Hamartin

1

10

High-throughput

0.481

High

439729

INSR
Insulin receptor

1

20

Small-scale

0.479

High

484136

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.479

High

541475

FGFR1
Fibroblast growth factor receptor 1

1

17

Small-scale

0.479

High

984105

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

986412

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

1045267

TF65
Transcription factor p65

1

5

High-throughput

0.479

High

1047902

TLE2
Transducin-like enhancer protein 2

1

4

High-throughput

0.479

High

1116649

GRB7
Growth factor receptor-bound protein 7

1

20

Small-scale

0.479

High

1116651

EEA1
Early endosome antigen 1

1

5

High-throughput

0.479

High

1116666

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.479

High

1116703

TES
Testin

1

11

High-throughput

0.479

High

1116672

Q86WV8
TSC complex subunit 1

1

3

High-throughput

0.470

High

1116663

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1116678

FLCN
Folliculin

1

0

Small-scale

0.458

High

262229

SCN2B
Sodium channel regulatory subunit beta-2

1

1

High-throughput

0.445

High

640163

EPHA1
Ephrin type-A receptor 1

1

9

High-throughput

0.445

High

1110436

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.445

High

1116665

PKHG7
Pleckstrin homology domain-containing family G member 7

1

7

High-throughput

0.445

High

371973

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.437

High

388188

GLPA
Glycophorin-A

1

0

High-throughput

0.426

High

633422

ANPRB
Atrial natriuretic peptide receptor 2

1

0

High-throughput

0.426

High

1116667

FBX50
F-box only protein 50

1

0

High-throughput

0.426

High

1116655

ITSN1
Intersectin-1

1

13

High-throughput

0.408

High

1116684

COA7
Cytochrome c oxidase assembly factor 7

1

1

High-throughput

0.407

High

1116693

SPNDC
Spindlin interactor and repressor of chromatin-binding protein

2

0

High-throughput

0.298

High

261497

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

959467

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.279

Low

1116658

AMZ1
Archaemetzincin-1

1

0

High-throughput

0.279

Low

1116705

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

0

High-throughput

0.279

Low

1116690

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.232

Low

1116701

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.232

Low

1116706

EXOG
Nuclease EXOG, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025