HitPredict

Interactor 1: DYR1A (Q61214)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (MP86) (Protein kinase minibrain homolog) (MNBH)
Gene: Dyrk1a

Interactor 2: TSC1 (Q9EP53)
Hamartin (Tuberous sclerosis 1 protein homolog)
Gene: TSC1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 763 Mm			1 1161
+	Hs
		1044003 DYR1A_HUMAN (1-763): 0: 636: 99.21		TSC1_HUMAN (1-1161): 0: 767: 86.98
+	Hs
		148781 DYR1A_HUMAN (1-763): 0: 636: 99.21		CTRO_HUMAN (326-1095): 8.06e-30: 131: 10.51
+	Hs
		528372 DYR1A_HUMAN (1-763): 0: 636: 99.21		MYH6_HUMAN (395-1133): 3.51e-26: 119: 8.77
+	Hs
		728476 DYR1A_HUMAN (1-763): 0: 636: 99.21		MYH11_HUMAN (796-1161): 5.47e-11: 69.5: 12.30
+	Hs
		725159 DYR1A_HUMAN (1-763): 0: 636: 99.21		MYH10_HUMAN (617-910): 9.54e-10: 65.3: 13.27
+	Hs
		148173 DYRK3_HUMAN (6-485): 4.88e-119: 372: 32.65		CTRO_HUMAN (326-1095): 8.06e-30: 131: 10.51
+	Hs
		522542 CDK3_HUMAN (156-487): 5.57e-126: 379: 27.43		MYH1_HUMAN (370-1133): 3.75e-27: 122: 10.15
+	Hs
		960128 CDK3_HUMAN (156-487): 5.57e-126: 379: 27.43		MYH2_HUMAN (370-1133): 2.91e-27: 122: 10.41
+	Hs
		148286 CDK1_HUMAN (156-482): 2.6e-121: 367: 26.57		CTRO_HUMAN (326-1095): 8.06e-30: 131: 10.51
+	Hs
		522604 CDK3_HUMAN (156-487): 5.57e-126: 379: 27.43		MYH7_HUMAN (394-1133): 2.36e-26: 119: 8.63
+	Hs
		528368 CDK3_HUMAN (156-487): 5.57e-126: 379: 27.43		MYH6_HUMAN (395-1133): 3.51e-26: 119: 8.77
+	Hs
		551610 CDK2_HUMAN (156-489): 8.32e-127: 381: 27.86		DESP_HUMAN (548-1138): 1.55e-25: 117: 11.54
+	Hs
		625176 CDK2_HUMAN (156-489): 8.32e-127: 381: 27.86		MYH9_HUMAN (649-1160): 1.28e-25: 117: 10.68
+	Hs
		625530 CDK2_HUMAN (156-489): 8.32e-127: 381: 27.86		MY18A_HUMAN (367-910): 1.36e-20: 101: 9.71
+	Hs
		502908 CDK3_HUMAN (156-487): 5.57e-126: 379: 27.43		MYH3_HUMAN (312-981): 2.28e-20: 100: 12.05
+	Hs
		528401 CDK2_HUMAN (156-489): 8.32e-127: 381: 27.86		MYH8_HUMAN (320-965): 4.76e-19: 96.1: 10.81
+	Hs
		528405 CDK3_HUMAN (156-487): 5.57e-126: 379: 27.43		MYH8_HUMAN (320-965): 4.76e-19: 96.1: 10.81
+	Hs
		960129 CDK3_HUMAN (156-487): 5.57e-126: 379: 27.43		MYH13_HUMAN (405-976): 2.04e-18: 93.7: 12.80
+	Hs
		625177 CDK2_HUMAN (156-489): 8.32e-127: 381: 27.86		MYH10_HUMAN (617-910): 9.54e-10: 65.3: 13.27
+	Sc
		615128 BUR1_YEAST (154-747): 6.03e-119: 374: 17.51		SP110_YEAST (700-982): 3.87e-10: 66.3: 18.97