HitPredict

Interactor 1: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Interactor 2: PPIE (Q9UNP9)
Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)
Gene: PPIE

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27684187
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pro_isomerase~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 164 Hs			1 301
+	Hs
		1084450 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		1028873 SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		516744 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		1028634 SRSF9_HUMAN (9-82): 1.91e-19: 83.2: 40.79		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		993869 SRSF4_HUMAN (11-112): 3.43e-16: 76.6: 39.22		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		1029160 SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	At
		1340387 SR30_ARATH (5-90): 4.74e-26: 101: 44.32		CYP63_ARATH (134-299): 1.18e-89: 279: 58.62
+	At
		186870 SR34_ARATH (5-88): 5.4e-23: 93.9: 45.35		CYP63_ARATH (134-299): 1.18e-89: 279: 58.62
+	Hs
		614281 NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14		PPIB_HUMAN (143-300): 5.03e-63: 199: 58.49
+	Hs
		266956 SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54		PPIA_HUMAN (137-300): 3.31e-63: 198: 66.46
+	Hs
		923771 RBM4_HUMAN (11-88): 3.45e-18: 81.9: 28.21		PPIA_HUMAN (137-300): 3.31e-63: 198: 66.46