HitPredict

Interactor 1: M3K7 (Q62073)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: Map3k7

Interactor 2: JIP1 (Q9WVI9)
C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain-1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
Gene: Mapk8ip1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	17709393
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007254 - JNK cascade GO:0046330 - positive regulation of JNK cascade
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 579 Mm			1 707
+	Mm
		1265829 Q923A8_MOUSE (1-579): 0: 541: 95.38		JIP1_MOUSE (1-707): 0: 783: 100.00
+	Hs
		201469 M3K7_HUMAN (1-579): 0: 540: 94.88		JIP1_HUMAN (1-707): 0: 730: 92.42
+	Hs
		1083525 M3K11_HUMAN (10-492): 9.58e-114: 360: 26.82		JIP1_HUMAN (1-707): 0: 730: 92.42
+	Hs
		972470 M3K10_HUMAN (29-438): 1.2e-99: 325: 29.16		JIP1_HUMAN (1-707): 0: 730: 92.42
+	Hs
		1032911 M3K11_HUMAN (10-492): 9.58e-114: 360: 26.82		JIP2_HUMAN (21-266): 8.52e-45: 174: 32.30
+	Hs
		665145 EPHA2_HUMAN (16-358): 3.85e-100: 327: 26.93		SHC1_HUMAN (413-696): 5.55e-57: 205: 15.02
+	Hs
		972457 M3K10_HUMAN (29-438): 1.2e-99: 325: 29.16		JIP2_HUMAN (21-266): 8.52e-45: 174: 32.30