HitPredict

Interactor 1: PLEC (Q15149)
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
Gene: PLEC

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	24457600, 36517590
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 4684 Hs			1 746
+	Mm
		1231081 PLEC_MOUSE (1-4684): 0: 1757: 93.27		Q6AXH7_MOUSE (1-746): 0: 833: 96.41
+	Hs
		355527 PLEC_HUMAN (1-4684): 0: 1793: 100.00		NSD2_HUMAN (275-729): 1.3e-91: 314: 16.03
+	Hs
		1143278 PLEC_HUMAN (1-4684): 0: 1793: 100.00		ASH1L_HUMAN (356-733): 8.9e-72: 257: 20.66
+	Hs
		555694 ACTN1_HUMAN (153-894): 1.99e-116: 396: 23.90		EZH2_HUMAN (1-746): 0: 864: 100.00
+	Hs
		1028780 SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83		EZH2_HUMAN (1-746): 0: 864: 100.00
+	Hs
		587677 DESP_HUMAN (404-1000): 1.7e-12: 76.9: 9.56		EZH2_HUMAN (1-746): 0: 864: 100.00
+	Dm
		55687 A1Z9J3_DROME (3238-4176): 1.06e-09: 67.7: 17.28		SET1_DROME (611-732): 1.28e-18: 93.2: 38.71