HitPredict

Interactor 1: PHC1 (Q64028)
Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28)
Gene: PHC1

Interactor 2: RING2 (Q9CQJ4)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2)
Gene: Rnf2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.742

Property	Details
Experiments	23207902, 17296600, 22496869, 15741318, 12183370, 18650381, 22325148
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001739 - sex chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0008270 - zinc ion binding GO:0016604 - nuclear body and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1010 Mm			1 336
+	Hs
		943084 PHC1_HUMAN (1-1010): 7.84e-87: 303: 91.98		RING2_HUMAN (1-336): 2.74e-106: 315: 99.70
+	Hs
		943060 PHC1_HUMAN (1-1010): 7.84e-87: 303: 91.98		RING1_HUMAN (10-336): 3.44e-66: 215: 51.75
+	Mm
		639473 PHC1_MOUSE (1-1010): 6.25e-90: 311: 100.00		BMI1_MOUSE (34-332): 5.9e-42: 150: 17.16
+	Mm
		1225135 SCMH1_MOUSE (603-1009): 7.51e-35: 144: 17.40		RING2_MOUSE (1-336): 2.13e-106: 316: 100.00
+	Hs
		943088 PHC1_HUMAN (1-1010): 7.84e-87: 303: 91.98		PCGF6_HUMAN (30-293): 1.72e-44: 157: 15.36
+	Hs
		717684 PHC1_HUMAN (1-1010): 7.84e-87: 303: 91.98		BMI1_HUMAN (34-332): 2.52e-42: 151: 16.83
+	Hs
		943064 PHC1_HUMAN (1-1010): 7.84e-87: 303: 91.98		PCGF3_HUMAN (36-334): 2.56e-43: 151: 17.16
+	Mm
		620786 PHC1_MOUSE (1-1010): 6.25e-90: 311: 100.00		PCGF2_MOUSE (34-332): 1.26e-37: 139: 16.17
+	Hs
		718390 PHC1_HUMAN (1-1010): 7.84e-87: 303: 91.98		PCGF2_HUMAN (34-332): 3.57e-40: 145: 15.51
+	Hs
		943070 PHC1_HUMAN (1-1010): 7.84e-87: 303: 91.98		PCGF5_HUMAN (34-334): 2.53e-39: 141: 18.24
+	Hs
		943087 PHC1_HUMAN (1-1010): 7.84e-87: 303: 91.98		PCGF1_HUMAN (28-336): 1.37e-35: 131: 16.56
+	Hs
		943066 PHC1_HUMAN (1-1010): 7.84e-87: 303: 91.98		Q5T8Z6_HUMAN (34-129): 4.38e-33: 120: 27.27
+	Dm
		1341979 Q9NF31_DROME (412-1009): 8.58e-50: 194: 21.33		Q9VV77_DROME (36-334): 4.84e-45: 155: 18.69
+	Dm
		1374688 Q9W523_DROME (412-1009): 8.84e-47: 185: 21.33		Q9VV77_DROME (36-334): 4.84e-45: 155: 18.69
+	Dm
		728804 Q9NF31_DROME (412-1009): 8.58e-50: 194: 21.33		PSC_DROME (4-336): 6.6e-34: 134: 16.77
+	Hs
		554277 MUC1_HUMAN (218-965): 1.84e-35: 148: 10.57		BMI1_HUMAN (34-332): 2.52e-42: 151: 16.83
+	Hs
		718098 SCMH1_HUMAN (603-1009): 3.03e-33: 139: 16.20		BMI1_HUMAN (34-332): 2.52e-42: 151: 16.83
+	Dm
		1341975 Q9NF31_DROME (412-1009): 8.58e-50: 194: 21.33		RING1_DROME (204-333): 1.12e-19: 91.3: 40.15
+	Dm
		728808 SCM_DROME (506-1007): 5.29e-36: 149: 14.29		PSC_DROME (4-336): 6.6e-34: 134: 16.77
+	Dm
		1361710 SCM_DROME (506-1007): 5.29e-36: 149: 14.29		RING1_DROME (204-333): 1.12e-19: 91.3: 40.15