HitPredict

Interactor 1: SIGIR (Q6IA17)
Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)
Gene: SIGIRR

Interactor 2: MYD88 (Q99836)
Myeloid differentiation primary response protein MyD88
Gene: MYD88

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	15866876, 20364327
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 410 Hs			1 296
+	Mm
		607556 IL1AP_MOUSE (8-326): 9.25e-89: 281: 22.39		MYD88_MOUSE (1-296): 6.79e-129: 370: 81.76
+	Hs
		120156 SIGIR_HUMAN (1-410): 1.3e-165: 472: 100.00		TLR4_HUMAN (153-293): 2.58e-46: 168: 26.00
+	Hs
		1306780 IL1AP_HUMAN (8-326): 9.29e-90: 283: 23.31		MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00
+	Mm
		528283 IL1R1_MOUSE (9-328): 2.26e-80: 259: 19.83		MYD88_MOUSE (1-296): 6.79e-129: 370: 81.76
+	Hs
		965959 ILRL1_HUMAN (9-320): 1.43e-83: 267: 22.94		MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00
+	Hs
		540400 IL1R1_HUMAN (9-337): 3.46e-82: 264: 20.46		MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00
+	Hs
		540394 SIGIR_HUMAN (1-410): 1.3e-165: 472: 100.00		IL1R1_HUMAN (154-295): 1.62e-38: 144: 14.63
+	Hs
		1151861 SIGIR_HUMAN (1-410): 1.3e-165: 472: 100.00		SIGIR_HUMAN (157-294): 1.27e-30: 120: 22.67
+	Hs
		1035369 IL1AP_HUMAN (8-326): 9.29e-90: 283: 23.31		IL18R_HUMAN (131-294): 8.65e-50: 174: 21.98
+	Hs
		965962 IL1AP_HUMAN (8-326): 9.29e-90: 283: 23.31		ILRL1_HUMAN (144-296): 1.54e-45: 163: 16.67
+	Mm
		539698 IL1AP_MOUSE (8-326): 9.25e-89: 281: 22.39		ILRL1_MOUSE (145-296): 3.03e-45: 162: 17.32
+	Mm
		1143081 IL1AP_MOUSE (8-326): 9.25e-89: 281: 22.39		ILRL2_MOUSE (145-294): 5.91e-40: 148: 18.29
+	Hs
		1335086 IL1AP_HUMAN (8-326): 9.29e-90: 283: 23.31		ILRL2_HUMAN (145-293): 1.11e-38: 144: 16.96
+	Hs
		540402 IL1AP_HUMAN (8-326): 9.29e-90: 283: 23.31		IL1R1_HUMAN (154-295): 1.62e-38: 144: 14.63
+	Mm
		528285 IL1AP_MOUSE (8-326): 9.25e-89: 281: 22.39		IL1R1_MOUSE (154-294): 1.52e-37: 141: 16.56