HitPredict

Interactor 1: MED27 (Q6P2C8)
Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (P37 TRAP/SMCC/PC2 subunit) (Transcriptional coactivator CRSP34)
Gene: MED27

Interactor 2: MED30 (Q96HR3)
Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25)
Gene: MED30

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

The method score is based on:

Property	Details
Experiments	12584197, 24981860, 24882805, 35271311
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016592 - mediator complex and 7 others more... GO:0016567 - protein ubiquitination GO:0032968 - positive regulation of transcription elongation by RNA polymerase II GO:0035019 - somatic stem cell population maintenance GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II GO:0061630 - ubiquitin protein ligase activity GO:0070847 - core mediator complex
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	311
Hs

1	178

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024