Protein: CENPE
Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE)

Gene: CENPE
Organism: Homo sapiens
Interactions: 85
UniProt ID: Q02224

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000775 - chromosome, centromeric region
GO:0000776 - kinetochore
GO:0000779 - condensed chromosome, centromeric region
GO:0003777 - microtubule motor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1035499

CENPE
Centromere-associated protein E

2

14

Small-scale

0.743

High

251743

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

3

3

Small-scale

0.660

High

1035535

NUF2
Kinetochore protein Nuf2

2

4

Small-scale

0.642

High

568143

PLSL
Plastin-2

3

1

High-throughput

0.640

High

50898

SYCE3
Synaptonemal complex central element protein 3

3

0

High-throughput

0.634

High

270924

CLAP2
CLIP-associating protein 2

2

2

High-throughput

0.628

High

222953

PRC1
Protein regulator of cytokinesis 1

2

4

Small-scale

0.624

High

330880

KI20A
Kinesin-like protein KIF20A

1

17

High-throughput

0.618

High

1035506

PCM1
Pericentriolar material 1 protein

2

1

High-throughput

0.611

High

289977

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.585

High

1035500

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

2

4

High-throughput

0.584

High

1035524

NIN
Ninein

2

6

High-throughput

0.584

High

1035501

BFSP2
Phakinin

2

2

High-throughput

0.574

High

1035543

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

1

1

Small-scale

0.569

High

992142

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.561

High

1035540

HECD1
E3 ubiquitin-protein ligase HECTD1

1

4

High-throughput

0.553

High

187500

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.549

High

703540

MK01
Mitogen-activated protein kinase 1

1

0

Small-scale

0.537

High

134012

IPO5
Importin-5

1

2

High-throughput

0.536

High

336403

SVIL
Supervillin

1

2

High-throughput

0.536

High

682021

RBTN1
Rhombotin-1

1

4

High-throughput

0.536

High

729758

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

841699

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.536

High

1035503

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

2

High-throughput

0.536

High

1035505

CBX2
Chromobox protein homolog 2

1

2

High-throughput

0.536

High

1035507

RABE1
Rab GTPase-binding effector protein 1

1

1

High-throughput

0.536

High

1035508

MARE1
Microtubule-associated protein RP/EB family member 1

1

9

High-throughput

0.536

High

1035518

CLAP1
CLIP-associating protein 1

1

2

High-throughput

0.536

High

1035536

P63
Tumor protein 63

1

2

Small-scale

0.536

High

1035537

MED4
Mediator of RNA polymerase II transcription subunit 4

1

2

High-throughput

0.536

High

1035541

CP131
Centrosomal protein of 131 kDa

1

1

High-throughput

0.536

High

156028

SOCS6
Suppressor of cytokine signaling 6

1

3

High-throughput

0.515

High

1035519

KTN1
Kinectin

1

2

High-throughput

0.515

High

1035521

MISP
Mitotic interactor and substrate of PLK1

1

0

High-throughput

0.513

High

1035523

SYNPO
Synaptopodin

1

0

High-throughput

0.513

High

507854

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

889397

CLK1
Dual specificity protein kinase CLK1

1

9

High-throughput

0.501

High

967673

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

4

Small-scale

0.501

High

1035529

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

High-throughput

0.501

High

859576

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.493

High

1035538

RED2
Double-stranded RNA-specific editase B2

1

4

High-throughput

0.489

High

1035502

CUL1
Cullin-1

1

6

Small-scale

0.481

High

1035509

SEPT7
Septin-7

1

1

Small-scale

0.481

High

1035533

DUX5
Double homeobox protein 5

1

2

High-throughput

0.481

High

1035534

TRAF4
TNF receptor-associated factor 4

1

3

Small-scale

0.481

High

129717

CBX4
E3 SUMO-protein ligase CBX4

1

2

High-throughput

0.479

High

163921

NDC80
Kinetochore protein NDC80 homolog

1

3

High-throughput

0.479

High

170092

AURKA
Aurora kinase A

1

2

High-throughput

0.479

High

256836

H2B1K
Histone H2B type 1-K

1

9

High-throughput

0.479

High

413657

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

462363

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

6

High-throughput

0.479

High

565872

EF2
Elongation factor 2

1

3

High-throughput

0.479

High

683829

MOES
Moesin

1

6

High-throughput

0.479

High

845288

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

3

High-throughput

0.479

High

980705

H2B1C
Histone H2B type 1-C/E/F/G/I

1

9

High-throughput

0.479

High

1035504

DCTN1
Dynactin subunit 1

1

8

High-throughput

0.479

High

1035510

RBBP7
Histone-binding protein RBBP7

1

4

High-throughput

0.479

High

1035513

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.479

High

1035516

SYNE3
Nesprin-3

1

3

High-throughput

0.479

High

1035522

MIRO2
Mitochondrial Rho GTPase 2

1

7

High-throughput

0.479

High

1035526

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

1035527

BICD2
Protein bicaudal D homolog 2

1

2

High-throughput

0.479

High

1035528

TITIN
Titin

1

2

High-throughput

0.479

High

1035531

BICD1
Protein bicaudal D homolog 1

1

2

High-throughput

0.479

High

1035542

NINL
Ninein-like protein

1

5

High-throughput

0.479

High

679138

DNJB1
DnaJ homolog subfamily B member 1

1

0

Small-scale

0.460

High

49310

SHOT1
Shootin-1

1

0

High-throughput

0.458

High

138071

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.458

High

1035517

DET1
DET1 homolog

1

0

High-throughput

0.458

High

1035520

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

1035525

NKAP
NF-kappa-B-activating protein

1

0

Small-scale

0.458

High

228409

DUX1
Double homeobox protein 1

1

2

High-throughput

0.457

High

883889

CENPF
Centromere protein F

1

7

Small-scale

0.457

High

765410

BMI1
Polycomb complex protein BMI-1

1

7

High-throughput

0.445

High

907386

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

Small-scale

0.445

High

1007667

RAE1L
mRNA export factor RAE1

1

4

Small-scale

0.445

High

1035512

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.445

High

318732

RHBT1
Rho-related BTB domain-containing protein 1

1

7

High-throughput

0.437

High

1035514

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

1035515

SAS6
Spindle assembly abnormal protein 6 homolog

1

1

High-throughput

0.437

High

1035539

GGA2
ADP-ribosylation factor-binding protein GGA2

1

3

High-throughput

0.437

High

1035511

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

1

High-throughput

0.407

High

1035530

RM24
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.279

Low

1035532

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025