HitPredict

Interactor 1: MDEAS (Q6PJG2)
Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1)
Gene: MIDEAS

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.930

Property	Details
Experiments	26496610, 35271311, 21258344, 23752268, 26949739
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl
Common GO terms	GO:0000118 - histone deacetylase complex GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1045 Hs			1 488
+	Hs
		1038472 MDEAS_HUMAN (1-1045): 2.44e-153: 484: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1270415 MTA3_HUMAN (685-1043): 4.18e-89: 299: 14.18		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1189328 MIER3_HUMAN (663-1012): 2.26e-77: 266: 17.24		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1031919 MTA1_HUMAN (682-1043): 1.69e-74: 262: 13.92		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1229946 MIER1_HUMAN (660-1038): 3.46e-75: 259: 17.96		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		936428 MTA2_MOUSE (682-1043): 5.29e-74: 260: 14.58		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		296092 MTA2_HUMAN (682-1043): 2.3e-72: 255: 14.32		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		936419 MTA1_MOUSE (682-1043): 6.17e-72: 255: 14.43		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		91458 E7EQY4_HUMAN (685-1043): 6.95e-96: 315: 14.21		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038636 TREF1_HUMAN (99-1045): 6.17e-87: 306: 25.05		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038676 MTA3_HUMAN (685-1043): 4.18e-89: 299: 14.18		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038488 MIER3_HUMAN (663-1012): 2.26e-77: 266: 17.24		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		140317 MTA2_MOUSE (682-1043): 5.29e-74: 260: 14.58		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		1031849 MTA1_HUMAN (682-1043): 1.69e-74: 262: 13.92		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038525 MIER1_HUMAN (660-1038): 3.46e-75: 259: 17.96		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		140302 MTA1_MOUSE (682-1043): 6.17e-72: 255: 14.43		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		296017 MTA2_HUMAN (682-1043): 2.3e-72: 255: 14.32		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Dm
		1276548 Q9VNF6_DROME (682-1005): 7.95e-62: 229: 14.12		HDAC1_DROME (5-472): 0: 653: 77.92
+	Dm
		81423 B7Z0T5_DROME (682-1005): 4.51e-61: 226: 14.12		HDAC1_DROME (5-472): 0: 653: 77.92
+	Hs
		1038521 RCOR2_HUMAN (703-1016): 7.23e-58: 210: 17.93		HDAC1_HUMAN (1-443): 0: 642: 90.07