Protein: MA2B2
Epididymis-specific alpha-mannosidase (EC 3.2.1.24) (Alpha-1,6-mannosidase) (Mannosidase alpha class 2B member 2)

Gene: MA2B2, MAN2B2
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q9Y2E5

Gene Ontology (top 5):
GO:0004559 - alpha-mannosidase activity
GO:0005764 - lysosome
GO:0006013 - mannose metabolic process
GO:0009313 - oligosaccharide catabolic process
GO:0030246 - carbohydrate binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1448337

FBX6
F-box only protein 6

4

4

High-throughput

0.694

High

1034851

NAAA
N-acylethanolamine-hydrolyzing acid amidase

3

2

High-throughput

0.667

High

1413827

FUCO2
Plasma alpha-L-fucosidase

2

0

High-throughput

0.602

High

1460870

FBX2
F-box only protein 2

2

4

High-throughput

0.601

High

1437652

SIAE
Sialate O-acetylesterase

2

0

High-throughput

0.585

High

332804

KCNK5
Potassium channel subfamily K member 5

2

0

High-throughput

0.580

High

1328005

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

0

High-throughput

0.580

High

1352558

GPX8
Probable glutathione peroxidase 8

2

1

High-throughput

0.553

High

171029

CLGN
Calmegin

2

4

High-throughput

0.549

High

86053

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

1

High-throughput

0.536

High

224529

PI15
Peptidase inhibitor 15

1

2

High-throughput

0.536

High

268945

FCG3B
Low affinity immunoglobulin gamma Fc region receptor III-B

1

3

High-throughput

0.536

High

548648

MPRI
Cation-independent mannose-6-phosphate receptor

1

2

High-throughput

0.536

High

568023

PRG2
Bone marrow proteoglycan

1

4

High-throughput

0.536

High

628476

KLK2
Kallikrein-2

1

10

High-throughput

0.536

High

933248

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

1

High-throughput

0.536

High

1210421

MANEA
Glycoprotein endo-alpha-1,2-mannosidase

1

1

High-throughput

0.536

High

1369089

GGH
Gamma-glutamyl hydrolase

1

2

High-throughput

0.536

High

1458676

DNJB9
DnaJ homolog subfamily B member 9

1

3

High-throughput

0.536

High

592753

LEUK
Leukosialin

1

0

High-throughput

0.513

High

647418

IDS
Iduronate 2-sulfatase

1

0

High-throughput

0.513

High

946271

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

0

High-throughput

0.513

High

1433387

DPEP2
Dipeptidase 2

1

0

High-throughput

0.513

High

73870

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

10

High-throughput

0.489

High

168467

NCTR3
Natural cytotoxicity triggering receptor 3

1

2

High-throughput

0.489

High

388754

C1QB
Complement C1q subcomponent subunit B

1

12

High-throughput

0.489

High

426155

PPB1
Alkaline phosphatase, placental type

1

1

High-throughput

0.489

High

467732

CEL2B
Chymotrypsin-like elastase family member 2B

1

1

High-throughput

0.489

High

597818

CRIS2
Cysteine-rich secretory protein 2

1

2

High-throughput

0.489

High

880079

DNSL1
Deoxyribonuclease-1-like 1

1

2

High-throughput

0.489

High

935819

MFAP4
Microfibril-associated glycoprotein 4

1

2

High-throughput

0.489

High

976880

LCN6
Epididymal-specific lipocalin-6

1

2

High-throughput

0.489

High

1030232

IL5RA
Interleukin-5 receptor subunit alpha

1

3

High-throughput

0.489

High

1225873

WDR25
WD repeat-containing protein 25

1

2

High-throughput

0.489

High

1236114

FSTL4
Follistatin-related protein 4

1

5

High-throughput

0.489

High

1248599

LYPD4
Ly6/PLAUR domain-containing protein 4

1

1

High-throughput

0.489

High

1248814

LYZL1
Lysozyme-like protein 1

1

5

High-throughput

0.489

High

1347310

FIBIN
Fin bud initiation factor homolog

1

3

High-throughput

0.489

High

1359280

CA054
Uncharacterized protein C1orf54

1

3

High-throughput

0.489

High

1432130

KLK15
Kallikrein-15

1

8

High-throughput

0.489

High

1439384

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.489

High

1449636

CBLN4
Cerebellin-4

1

12

High-throughput

0.489

High

218983

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.437

High

399472

TRGV3
T cell receptor gamma variable 3

1

1

High-throughput

0.407

High

1243532

CSAG1
Chondrosarcoma-associated gene 1 protein

1

2

High-throughput

0.407

High

1165385

ODAPH
Odontogenesis associated phosphoprotein

2

0

High-throughput

0.328

High

1416319

PRR14
Proline-rich protein 14

2

0

High-throughput

0.328

High

1281210

CPLX4
Complexin-4

2

0

High-throughput

0.316

High

1366009

APBP2
Amyloid protein-binding protein 2

2

0

High-throughput

0.316

High

1384383

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

0

High-throughput

0.316

High

1419127

KRA32
Keratin-associated protein 3-2

2

0

High-throughput

0.316

High

1433040

LIME1
Lck-interacting transmembrane adapter 1

2

0

High-throughput

0.316

High

1490693

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

0

High-throughput

0.316

High

327094

NXPH3
Neurexophilin-3

1

0

High-throughput

0.279

Low

342700

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

570725

EDN3
Endothelin-3

1

0

High-throughput

0.279

Low

597019

TSHR
Thyrotropin receptor

1

0

High-throughput

0.279

Low

783078

TCF7
Transcription factor 7

1

0

High-throughput

0.279

Low

866455

CASA1
Alpha-S1-casein [Cleaved into: Casoxin-D]

1

0

High-throughput

0.279

Low

1179166

TECT1
Tectonic-1

1

0

High-throughput

0.279

Low

1208247

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

1333795

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.279

Low

1383429

CC74A
Coiled-coil domain-containing protein 74A

1

0

High-throughput

0.279

Low

1399961

DUX3
Putative double homeobox protein 3

1

0

High-throughput

0.279

Low

1411492

TM2D3
TM2 domain-containing protein 3

1

0

High-throughput

0.279

Low

1430748

SIRPD
Signal-regulatory protein delta

1

0

High-throughput

0.279

Low

1449927

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.279

Low

1450353

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.279

Low

1490692

LIPG
Endothelial lipase

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025