Protein: MA2A1
Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)

Gene: MA2A1, MAN2A1
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q16706

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001701 - in utero embryonic development
GO:0001889 - liver development
GO:0004559 - alpha-mannosidase activity
GO:0004572 - mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1042628

UPAR
Urokinase plasminogen activator surface receptor

3

1

High-throughput

0.667

High

1116210

PTC1
Protein patched homolog 1

3

1

High-throughput

0.667

High

1162154

FUT8
Alpha-(1,6)-fucosyltransferase

2

1

High-throughput

0.628

High

1162160

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

1

High-throughput

0.628

High

1162133

BRID5
BRICHOS domain-containing protein 5

2

0

High-throughput

0.576

High

1101339

SG2A2
Mammaglobin-A

2

2

High-throughput

0.574

High

396213

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

1162132

S39A4
Zinc transporter ZIP4

2

6

High-throughput

0.552

High

976807

LCN6
Epididymal-specific lipocalin-6

2

2

High-throughput

0.549

High

1162143

CA054
Uncharacterized protein C1orf54

2

3

High-throughput

0.549

High

341312

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.536

High

380432

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

4

High-throughput

0.536

High

519618

LYAG
Lysosomal alpha-glucosidase

1

1

High-throughput

0.536

High

567869

PRG2
Bone marrow proteoglycan

1

4

High-throughput

0.536

High

593384

PGFRA
Platelet-derived growth factor receptor alpha

1

1

High-throughput

0.536

High

698699

CALX
Calnexin

1

4

High-throughput

0.536

High

731851

CEAM8
Cell adhesion molecule CEACAM8

1

2

High-throughput

0.536

High

1162127

CL12B
C-type lectin domain family 12 member B

1

4

High-throughput

0.536

High

548021

PSPC
Surfactant protein C

1

0

High-throughput

0.513

High

286544

SG2A1
Mammaglobin-B

1

2

High-throughput

0.489

High

1162135

LYZL1
Lysozyme-like protein 1

1

5

High-throughput

0.489

High

1162137

LYZL2
Lysozyme-like protein 2

1

5

High-throughput

0.489

High

1162138

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.489

High

1162142

FIBIN
Fin bud initiation factor homolog

1

3

High-throughput

0.489

High

1162150

LCFC1
Sperm-egg fusion protein LLCFC1

1

2

High-throughput

0.489

High

1162153

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

12

High-throughput

0.489

High

1162164

ST14
Suppressor of tumorigenicity 14 protein

1

1

High-throughput

0.489

High

728777

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

1

High-throughput

0.479

High

1034735

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

2

High-throughput

0.479

High

1144598

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

1

High-throughput

0.479

High

1162156

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.479

High

1162155

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

0

Small-scale

0.458

High

449605

KLK1
Kallikrein-1

1

10

High-throughput

0.445

High

1139437

S39AE
Metal cation symporter ZIP14

1

6

High-throughput

0.445

High

1162131

NPAL3
NIPA-like protein 3

1

3

High-throughput

0.445

High

1162145

S39A7
Zinc transporter SLC39A7

1

6

High-throughput

0.445

High

1162162

PRG3
Proteoglycan 3

1

4

High-throughput

0.445

High

1162165

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

2

High-throughput

0.445

High

218234

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.437

High

1162136

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1162147

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

1162158

T106B
Transmembrane protein 106B

1

1

High-throughput

0.437

High

139220

UPK2
Uroplakin-2

1

0

High-throughput

0.426

High

1162128

NTCP5
Sodium/bile acid cotransporter 5

1

0

High-throughput

0.426

High

1162130

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1162141

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.426

High

1162148

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.426

High

1162149

MFSD3
Major facilitator superfamily domain-containing protein 3

1

0

High-throughput

0.426

High

1162163

TMED5
Transmembrane emp24 domain-containing protein 5

1

0

High-throughput

0.426

High

73809

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

10

High-throughput

0.407

High

170777

CLGN
Calmegin

1

4

High-throughput

0.407

High

388779

C1QC
Complement C1q subcomponent subunit C

1

12

High-throughput

0.407

High

505828

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

1

10

High-throughput

0.407

High

663548

CMA1
Chymase

1

9

High-throughput

0.407

High

880014

DNSL1
Deoxyribonuclease-1-like 1

1

2

High-throughput

0.407

High

1128895

I13R2
Interleukin-13 receptor subunit alpha-2

1

4

High-throughput

0.407

High

1154980

ADIPO
Adiponectin

1

12

High-throughput

0.407

High

1162134

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

2

High-throughput

0.407

High

1162146

SL9A6
Sodium/hydrogen exchanger 6

1

1

High-throughput

0.407

High

1162157

S39A9
Zinc transporter ZIP9

1

6

High-throughput

0.407

High

964982

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

1162129

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1162152

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low

1162161

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

653341

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

1162139

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.232

Low

1162140

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

1162144

PATE1
Prostate and testis expressed protein 1

1

0

High-throughput

0.232

Low

1162151

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.232

Low

1162159

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.232

Low

1148979

SC23B
Protein transport protein Sec23B

1

0

Small-scale

0.213

Low


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Last updated: 11Aug2025