Protein: MA2A2
Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)

Gene: MA2A2, MAN2A2
Organism: Homo sapiens
Interactions: 92
UniProt ID: P49641

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004559 - alpha-mannosidase activity
GO:0004572 - mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
GO:0006013 - mannose metabolic process
GO:0006486 - protein glycosylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

885480

S39A4
Zinc transporter ZIP4

4

6

High-throughput

0.691

High

568043

HLAE
HLA class I histocompatibility antigen, alpha chain E

3

1

High-throughput

0.667

High

885475

CL12A
C-type lectin domain family 12 member A

3

4

High-throughput

0.667

High

519595

LYAG
Lysosomal alpha-glucosidase

2

1

High-throughput

0.628

High

586173

CD1E
T-cell surface glycoprotein CD1e, membrane-associated

2

2

High-throughput

0.628

High

885504

FUT8
Alpha-(1,6)-fucosyltransferase

2

1

High-throughput

0.628

High

885515

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

1

High-throughput

0.628

High

380268

DRA
HLA class II histocompatibility antigen, DR alpha chain

2

3

High-throughput

0.611

High

885466

UPAR
Urokinase plasminogen activator surface receptor

3

1

High-throughput

0.609

High

885471

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

1

High-throughput

0.609

High

885484

GALT7
N-acetylgalactosaminyltransferase 7

2

0

High-throughput

0.602

High

885517

B4GT6
Beta-1,4-galactosyltransferase 6

2

0

High-throughput

0.595

High

885483

LYZL2
Lysozyme-like protein 2

2

5

High-throughput

0.574

High

885495

SL9A6
Sodium/hydrogen exchanger 6

2

1

High-throughput

0.574

High

170702

CLGN
Calmegin

2

4

High-throughput

0.549

High

885492

CA054
Uncharacterized protein C1orf54

2

3

High-throughput

0.549

High

341294

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.536

High

380411

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

4

High-throughput

0.536

High

567818

PRG2
Bone marrow proteoglycan

1

4

High-throughput

0.536

High

607354

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

1

High-throughput

0.536

High

627511

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

1

3

High-throughput

0.536

High

688535

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

4

High-throughput

0.536

High

885473

CL12B
C-type lectin domain family 12 member B

1

4

High-throughput

0.536

High

885478

NIPA3
Magnesium transporter NIPA3

1

3

High-throughput

0.536

High

885493

CLC2B
C-type lectin domain family 2 member B

1

4

High-throughput

0.536

High

141779

MFNG
Beta-1,3-N-acetylglucosaminyltransferase manic fringe

1

0

High-throughput

0.513

High

191436

SIA8E
Alpha-2,8-sialyltransferase 8E

1

0

High-throughput

0.513

High

214120

DHH
Desert hedgehog protein

1

0

High-throughput

0.513

High

885503

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

885509

LMA1L
Protein ERGIC-53-like

1

0

High-throughput

0.513

High

73782

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

10

High-throughput

0.489

High

168391

NCTR3
Natural cytotoxicity triggering receptor 3

1

2

High-throughput

0.489

High

388702

C1QB
Complement C1q subcomponent subunit B

1

12

High-throughput

0.489

High

593310

PGFRA
Platelet-derived growth factor receptor alpha

1

1

High-throughput

0.489

High

628397

KLK2
Kallikrein-2

1

10

High-throughput

0.489

High

731827

CEAM8
Cell adhesion molecule CEACAM8

1

2

High-throughput

0.489

High

879991

DNSL1
Deoxyribonuclease-1-like 1

1

2

High-throughput

0.489

High

885461

MFAP4
Microfibril-associated glycoprotein 4

1

2

High-throughput

0.489

High

885464

IL5RA
Interleukin-5 receptor subunit alpha

1

3

High-throughput

0.489

High

885465

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

2

High-throughput

0.489

High

885468

SG2A2
Mammaglobin-A

1

2

High-throughput

0.489

High

885469

PTC1
Protein patched homolog 1

1

1

High-throughput

0.489

High

885477

WDR25
WD repeat-containing protein 25

1

2

High-throughput

0.489

High

885481

LYZL1
Lysozyme-like protein 1

1

5

High-throughput

0.489

High

885486

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.489

High

885491

FIBIN
Fin bud initiation factor homolog

1

3

High-throughput

0.489

High

885496

GGH
Gamma-glutamyl hydrolase

1

2

High-throughput

0.489

High

885497

T106A
Transmembrane protein 106A

1

1

High-throughput

0.489

High

885500

LCFC1
Sperm-egg fusion protein LLCFC1

1

2

High-throughput

0.489

High

885505

CNTP3
Contactin-associated protein-like 3

1

2

High-throughput

0.489

High

885506

KLK15
Kallikrein-15

1

8

High-throughput

0.489

High

885511

CRLF2
Cytokine receptor-like factor 2

1

4

High-throughput

0.489

High

885512

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.489

High

885514

CBLN4
Cerebellin-4

1

12

High-throughput

0.489

High

885516

DNJB9
DnaJ homolog subfamily B member 9

1

3

High-throughput

0.489

High

885513

FBX6
F-box only protein 6

1

4

High-throughput

0.479

High

595351

H15
Histone H1.5

1

1

High-throughput

0.470

High

885489

ZNT7
Zinc transporter 7

1

2

High-throughput

0.445

High

885490

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

2

High-throughput

0.445

High

217961

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.437

High

399436

TRGV3
T cell receptor gamma variable 3

1

1

High-throughput

0.407

High

885470

S39AE
Metal cation symporter ZIP14

1

6

High-throughput

0.407

High

885479

NPAL3
NIPA-like protein 3

1

3

High-throughput

0.407

High

885482

NIPA1
Magnesium transporter NIPA1

1

3

High-throughput

0.407

High

885494

S39A7
Zinc transporter SLC39A7

1

6

High-throughput

0.407

High

885476

SUSD4
Sushi domain-containing protein 4

3

0

High-throughput

0.347

High

885485

TMM25
Transmembrane protein 25

3

0

High-throughput

0.347

High

885472

TAZ
Tafazzin

2

0

High-throughput

0.328

High

885498

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

2

0

High-throughput

0.313

High

327570

ELP1
Elongator complex protein 1

1

0

High-throughput

0.282

High

474546

VIME
Vimentin

1

0

High-throughput

0.282

High

569006

ENOB
Beta-enolase

1

0

High-throughput

0.282

High

885467

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.282

High

885520

GIT1
ARF GTPase-activating protein GIT1

1

0

High-throughput

0.282

High

885521

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.282

High

316658

LY6H
Lymphocyte antigen 6H

1

0

High-throughput

0.279

Low

885462

DEF1
Neutrophil defensin 1

1

0

High-throughput

0.279

Low

885487

MCLN2
Mucolipin-2

1

0

High-throughput

0.279

Low

885488

I17RC
Interleukin-17 receptor C

1

0

High-throughput

0.279

Low

885499

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.279

Low

885501

LR37B
Leucine-rich repeat-containing protein 37B

1

0

High-throughput

0.279

Low

885502

SEC62
Translocation protein SEC62

1

0

High-throughput

0.279

Low

885508

CST9L
Cystatin-9-like

1

0

High-throughput

0.279

Low

885510

UD17
UDP-glucuronosyltransferase 1A7

1

0

High-throughput

0.279

Low

885518

BTNL2
Butyrophilin-like protein 2

1

0

High-throughput

0.279

Low

885519

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.279

Low

400481

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

885463

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

2096

TVA20
T cell receptor alpha variable 20

1

0

High-throughput

0.232

Low

222256

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.232

Low

885474

DB109
Beta-defensin 109B

1

0

High-throughput

0.232

Low

885507

SPNS1
Protein spinster homolog 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025