HitPredict

Interactor 1: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Interactor 2: TARA (Q9H2D6)
TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin)
Gene: TRIOBP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PH
Common GO terms	GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1025 Hs			1 2365
+	Hs
		1329244 TARA_HUMAN (231-985): 1.44e-51: 201: 35.57		TARA_HUMAN (1-2365): 4.78e-172: 589: 100.00
+	Hs
		1153376 PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51		TARA_HUMAN (1-2365): 4.78e-172: 589: 100.00
+	Hs
		1167372 MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00		MPRIP_HUMAN (1554-2357): 2.27e-56: 217: 33.82
+	Hs
		724884 MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00		MYH9_HUMAN (1312-2225): 5.12e-28: 126: 8.32
+	Hs
		965125 MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00		ANK2_HUMAN (28-1012): 2.01e-09: 65.7: 14.82
+	Hs
		1153259 PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51		MPRIP_HUMAN (1554-2357): 2.27e-56: 217: 33.82
+	Hs
		148966 CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42		MPRIP_HUMAN (1554-2357): 2.27e-56: 217: 33.82
+	Hs
		725013 TARA_HUMAN (231-985): 1.44e-51: 201: 35.57		MYH9_HUMAN (1312-2225): 5.12e-28: 126: 8.32
+	Hs
		724876 PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51		MYH9_HUMAN (1312-2225): 5.12e-28: 126: 8.32
+	Hs
		148460 CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42		MYH9_HUMAN (1312-2225): 5.12e-28: 126: 8.32
+	Hs
		148461 CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42		MYH10_HUMAN (1444-2225): 5.59e-28: 126: 9.89
+	Hs
		148466 CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42		MYH11_HUMAN (1483-2225): 1.16e-25: 119: 10.65
+	Hs
		551742 PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51		DESP_HUMAN (1531-2365): 6.57e-16: 86.9: 10.21
+	Hs
		149481 CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42		PCLO_HUMAN (33-1474): 5.24e-20: 100: 10.73
+	Hs
		148941 CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42		NIPBL_HUMAN (297-1029): 2.39e-19: 98.5: 15.30
+	Hs
		148841 CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42		PLEC_HUMAN (1579-2357): 3.47e-16: 88.1: 12.43
+	Hs
		148359 CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42		DESP_HUMAN (1531-2365): 6.57e-16: 86.9: 10.21
+	Hs
		148818 CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42		MDC1_HUMAN (88-903): 1.81e-15: 85.4: 14.49
+	Hs
		148991 CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42		MYH14_HUMAN (2035-2363): 1.9e-15: 85.4: 15.06
+	Hs
		965158 PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24		ANK2_HUMAN (28-1012): 2.01e-09: 65.7: 14.82