HitPredict

Interactor 1: ASXL2 (Q76L83)
Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2)
Gene: ASXL2

Interactor 2: MBD6 (Q96DN6)
Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6)
Gene: MBD6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

Property	Details
Experiments	36180891, 26186194, 28514442, 27705803, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1435 Hs			1 1003
+	Hs
		1176274 ASXL2_HUMAN (1-1435): 0: 650: 100.00		MBD5_HUMAN (1-547): 5.23e-27: 121: 25.57
+	Hs
		1176247 ASXL2_HUMAN (1-1435): 0: 650: 100.00		KMT2C_HUMAN (294-823): 6.65e-14: 78.9: 18.80
+	Hs
		1288481 ASXL3_HUMAN (72-1435): 5.5e-14: 79.7: 12.34		MBD6_HUMAN (1-1003): 7.33e-99: 336: 100.00
+	Hs
		1220800 ASXL1_HUMAN (333-1435): 1.06e-13: 78.5: 12.31		MBD6_HUMAN (1-1003): 7.33e-99: 336: 100.00
+	Hs
		554259 MUC1_HUMAN (406-1391): 4.99e-47: 187: 11.21		MUC1_HUMAN (3-956): 9.92e-59: 222: 13.35
+	Hs
		990830 ZO1_HUMAN (94-797): 1.1e-29: 131: 11.81		ZO1_HUMAN (80-834): 1.01e-26: 120: 12.32
+	Hs
		1056827 MDC1_HUMAN (105-1326): 8.13e-25: 115: 9.03		MDC1_HUMAN (50-994): 2.38e-25: 116: 10.06
+	Dm
		113976 M9PB30_DROME (145-918): 2.71e-24: 113: 10.93		M9PB30_DROME (370-996): 9.47e-23: 108: 11.11
+	Hs
		1319310 ASXL3_HUMAN (72-1435): 5.5e-14: 79.7: 12.34		MBD5_HUMAN (1-547): 5.23e-27: 121: 25.57
+	Hs
		1220828 ASXL1_HUMAN (333-1435): 1.06e-13: 78.5: 12.31		MBD5_HUMAN (1-547): 5.23e-27: 121: 25.57
+	Dm
		1182373 Q7KU92_DROME (72-1197): 4.64e-26: 119: 10.97		Q9VLS7_DROME (31-657): 1.24e-13: 77.8: 11.15
+	Hs
		1056876 MICA3_HUMAN (309-913): 6.55e-13: 76.2: 15.72		MDC1_HUMAN (50-994): 2.38e-25: 116: 10.06
+	Hs
		990915 ASPP1_HUMAN (508-1019): 2.74e-09: 64.1: 9.34		ZO1_HUMAN (80-834): 1.01e-26: 120: 12.32
+	Hs
		152667 KMT2D_HUMAN (412-1023): 4.42e-14: 80: 13.50		KMT2C_HUMAN (294-823): 6.65e-14: 78.9: 18.80
+	Hs
		1243841 ASXL3_HUMAN (72-1435): 5.5e-14: 79.7: 12.34		KMT2C_HUMAN (294-823): 6.65e-14: 78.9: 18.80
+	Hs
		1220790 ASXL1_HUMAN (333-1435): 1.06e-13: 78.5: 12.31		KMT2C_HUMAN (294-823): 6.65e-14: 78.9: 18.80
+	Mm
		1351630 PCLO_MOUSE (162-1227): 1.76e-12: 75.1: 9.12		PCLO_MOUSE (11-895): 1.35e-09: 64.7: 10.77
+	Dm
		1214590 Q9VLS7_DROME (362-1082): 5.85e-10: 66.4: 12.21		Q8IQA6_DROME (6-973): 7.59e-12: 72: 12.26