Protein: MAK5
ATP-dependent RNA helicase MAK5 (EC 3.6.4.13) (Maintenance of killer protein 5)

Gene: MAK5
Organism: Saccharomyces cerevisiae S288C
Interactions: 170
UniProt ID: P38112

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

744233

HAS1
ATP-dependent RNA helicase HAS1

7

16

Small-scale

0.966

High

744187

CIC1
Proteasome-interacting protein CIC1

5

5

High-throughput

0.919

High

744261

DBP10
ATP-dependent RNA helicase DBP10

4

16

Small-scale

0.899

High

716175

SKI2
Antiviral helicase SKI2

2

15

High-throughput

0.759

High

481145

RL1A
Large ribosomal subunit protein uL1A

2

12

High-throughput

0.754

High

638732

SPB4
ATP-dependent rRNA helicase SPB4

2

18

High-throughput

0.754

High

744206

MTR4
ATP-dependent RNA helicase DOB1

2

17

Small-scale

0.754

High

744245

DBP9
ATP-dependent RNA helicase DBP9

2

16

Small-scale

0.754

High

742005

NOP4
Nucleolar protein 4

7

13

Small-scale

0.751

High

744250

NOP12
Nucleolar protein 12

6

20

High-throughput

0.730

High

744213

NSA1
Ribosome biogenesis protein NSA1

5

2

Small-scale

0.712

High

744230

NOG1
Nucleolar GTP-binding protein 1

5

9

Small-scale

0.712

High

744257

YTM1
Ribosome biogenesis protein YTM1

5

20

High-throughput

0.712

High

744259

MAK21
Ribosome biogenesis protein MAK21

5

14

High-throughput

0.712

High

744201

RLP7
Ribosome biogenesis protein RLP7

4

14

High-throughput

0.694

High

145719

RL36B
Large ribosomal subunit protein eL36B

1

5

High-throughput

0.691

High

710873

URB1
Nucleolar pre-ribosomal-associated protein 1

4

2

Small-scale

0.691

High

744202

NOP2
25S rRNA

4

10

Small-scale

0.691

High

744239

PUF6
Pumilio homology domain family member 6

4

4

Small-scale

0.687

High

744193

NOC2
Nucleolar complex protein 2

4

3

Small-scale

0.680

High

744189

RPF1
Ribosome production factor 1

3

4

High-throughput

0.670

High

744241

ERB1
Ribosome biogenesis protein ERB1

3

19

High-throughput

0.662

High

744243

RRP5
rRNA biogenesis protein RRP5

3

14

High-throughput

0.656

High

731799

EBP2
rRNA-processing protein EBP2

3

4

High-throughput

0.646

High

744188

SSF1
Ribosome biogenesis protein SSF1

3

8

Small-scale

0.643

High

744204

LOC1
60S ribosomal subunit assembly/export protein LOC1

2

2

High-throughput

0.634

High

593525

DBP3
ATP-dependent RNA helicase DBP3

1

12

Small-scale

0.618

High

699673

DRS1
ATP-dependent RNA helicase DRS1

1

14

High-throughput

0.618

High

733122

DBP7
ATP-dependent RNA helicase DBP7

1

16

High-throughput

0.618

High

744220

DBP6
ATP-dependent RNA helicase DBP6

1

15

Small-scale

0.618

High

744237

RUVB1
RuvB-like protein 1

1

6

High-throughput

0.618

High

744238

DHR1
Probable ATP-dependent RNA helicase DHR1

1

15

High-throughput

0.618

High

744244

HRQ1
ATP-dependent helicase HRQ1

1

17

Small-scale

0.618

High

383095

RL25
Large ribosomal subunit protein uL23

2

9

High-throughput

0.611

High

498893

RL4A
Large ribosomal subunit protein uL4A

2

8

High-throughput

0.611

High

534959

RL3
Large ribosomal subunit protein uL3

2

6

High-throughput

0.611

High

744218

PESC
Pescadillo homolog

2

6

High-throughput

0.601

High

744198

NSA2
Ribosome biogenesis protein NSA2

2

2

High-throughput

0.594

High

443930

CYAA
Adenylate cyclase

2

2

High-throughput

0.588

High

425908

RS19A
Small ribosomal subunit protein eS19A

2

11

High-throughput

0.584

High

594034

MAK11
Protein MAK11

2

20

Small-scale

0.584

High

744184

ENP1
Essential nuclear protein 1

2

8

High-throughput

0.584

High

744203

UTP10
U3 small nucleolar RNA-associated protein 10

2

6

High-throughput

0.584

High

744224

NOP15
Ribosome biogenesis protein 15

2

20

High-throughput

0.584

High

744258

NOP53
Ribosome biogenesis protein NOP53

2

4

High-throughput

0.584

High

733806

RPF2
Ribosome biogenesis protein RPF2

2

2

High-throughput

0.571

High

744234

CLU
Clustered mitochondria protein 1

2

0

High-throughput

0.563

High

399429

RLA0
Large ribosomal subunit protein uL10

2

9

High-throughput

0.558

High

640917

RL5
Large ribosomal subunit protein uL18

2

4

High-throughput

0.558

High

558019

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

4

High-throughput

0.553

High

604544

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

6

High-throughput

0.553

High

493755

HSP72
Heat shock protein SSA2

2

19

High-throughput

0.552

High

511021

SSB1
Ribosome-associated molecular chaperone SSB1

2

18

High-throughput

0.552

High

744199

SSB2
Ribosome-associated molecular chaperone SSB2

2

18

High-throughput

0.552

High

707841

GCN1
eIF-2-alpha kinase activator GCN1

2

16

High-throughput

0.537

High

404556

RL7A
Large ribosomal subunit protein uL30A

1

14

High-throughput

0.536

High

534744

RL30
Large ribosomal subunit protein eL30

1

4

High-throughput

0.536

High

667160

RL8B
Large ribosomal subunit protein eL8B

1

14

High-throughput

0.536

High

688521

KNS1
Dual specificity protein kinase KNS1

1

6

High-throughput

0.536

High

744227

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

4

High-throughput

0.536

High

744229

RL6A
Large ribosomal subunit protein eL6A

1

6

High-throughput

0.536

High

744231

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

18

High-throughput

0.536

High

744232

PKH3
Serine/threonine-protein kinase PKH3

1

17

High-throughput

0.536

High

744260

RL7B
Large ribosomal subunit protein uL30B

1

14

High-throughput

0.536

High

358024

RS17A
Small ribosomal subunit protein eS17A

2

7

High-throughput

0.533

High

478875

RL20B
Large ribosomal subunit protein eL20B

2

5

High-throughput

0.533

High

480626

RS8A
Small ribosomal subunit protein eS8A

2

8

High-throughput

0.533

High

706227

RS3A1
Small ribosomal subunit protein eS1A

2

10

High-throughput

0.533

High

409638

KAPC
cAMP-dependent protein kinase type 3

1

11

High-throughput

0.501

High

744196

EDC2
Enhancer of mRNA-decapping protein 2

1

0

High-throughput

0.493

High

479455

RS24A
Small ribosomal subunit protein eS24A

1

6

High-throughput

0.489

High

675983

XPO1
Exportin-1

1

17

High-throughput

0.489

High

744185

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

4

High-throughput

0.489

High

744265

RS22B
Small ribosomal subunit protein uS8B

1

9

High-throughput

0.489

High

744215

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.480

High

141286

RS9A
Small ribosomal subunit protein uS4A

1

11

High-throughput

0.479

High

382738

RL24A
Large ribosomal subunit protein eL24A

1

6

High-throughput

0.479

High

405577

RL26A
Large ribosomal subunit protein uL24A

1

10

High-throughput

0.479

High

406325

RL15A
Large ribosomal subunit protein eL15A

1

4

High-throughput

0.479

High

406513

RL22A
Large ribosomal subunit protein eL22A

1

5

High-throughput

0.479

High

406991

RS3
Small ribosomal subunit protein uS3

1

8

High-throughput

0.479

High

407871

RS13
Small ribosomal subunit protein uS15

1

7

High-throughput

0.479

High

413463

RS14A
Small ribosomal subunit protein uS11A

1

9

High-throughput

0.479

High

479728

RS4A
Small ribosomal subunit protein eS4A

1

3

High-throughput

0.479

High

480061

RS6A
Small ribosomal subunit protein eS6A

1

10

High-throughput

0.479

High

481325

RL2A
Large ribosomal subunit protein uL2A

1

8

High-throughput

0.479

High

501210

MAK16
Protein MAK16

1

4

High-throughput

0.479

High

543596

HSC82
ATP-dependent molecular chaperone HSC82

1

10

High-throughput

0.479

High

564271

RL8A
Large ribosomal subunit protein eL8A

1

14

High-throughput

0.479

High

597827

PWP1
Periodic tryptophan protein 1

1

20

High-throughput

0.479

High

630189

RRP43
Exosome complex component RRP43

1

2

High-throughput

0.479

High

631829

RS2
Small ribosomal subunit protein uS5

1

11

High-throughput

0.479

High

634399

SPB1
27S pre-rRNA

1

10

High-throughput

0.479

High

634570

KRR1
KRR1 small subunit processome component

1

9

High-throughput

0.479

High

635114

YCQ6
Uncharacterized protein YCR016W

1

1

High-throughput

0.479

High

645397

RS7A
Small ribosomal subunit protein eS7A

1

7

High-throughput

0.479

High

703038

MRT4
Ribosome assembly factor MRT4

1

9

High-throughput

0.479

High

715430

RRP1
Ribosomal RNA-processing protein 1

1

9

High-throughput

0.479

High

715921

UTP20
U3 small nucleolar RNA-associated protein 20

1

1

High-throughput

0.479

High

729867

RS27A
Small ribosomal subunit protein eS27A

1

6

High-throughput

0.479

High

737151

LONM
Lon protease homolog, mitochondrial

1

4

High-throughput

0.479

High

744190

RRP8
25S rRNA

1

2

High-throughput

0.479

High

744194

DPO5
rDNA transcriptional regulator POL5

1

2

High-throughput

0.479

High

744197

UTP7
U3 small nucleolar RNA-associated protein 7

1

20

High-throughput

0.479

High

744207

URB2
Nucleolar pre-ribosomal-associated protein 2

1

1

High-throughput

0.479

High

744217

UTP22
U3 small nucleolar RNA-associated protein 22

1

2

High-throughput

0.479

High

744219

YG5X
Putative methyltransferase YGR283C

1

3

High-throughput

0.479

High

744221

NOG2
Nucleolar GTP-binding protein 2

1

14

High-throughput

0.479

High

744222

NOP13
Nucleolar protein 13

1

15

High-throughput

0.479

High

744223

NAT10
RNA cytidine acetyltransferase

1

4

High-throughput

0.479

High

744228

RS15
Small ribosomal subunit protein uS19

1

6

High-throughput

0.479

High

744240

UTP14
U3 small nucleolar RNA-associated protein 14

1

5

High-throughput

0.479

High

744246

NOC4
Nucleolar complex protein 4

1

14

High-throughput

0.479

High

744247

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.479

High

744249

RLP24
Ribosome biogenesis protein RLP24

1

6

Small-scale

0.479

High

744251

BRX1
Ribosome biogenesis protein BRX1

1

20

High-throughput

0.479

High

744252

REXO4
RNA exonuclease 4

1

4

High-throughput

0.479

High

744255

RS10A
Small ribosomal subunit protein eS10A

1

9

High-throughput

0.479

High

744256

BMS1
Ribosome biogenesis protein BMS1

1

6

High-throughput

0.479

High

744262

NOP58
Nucleolar protein 58

1

10

High-throughput

0.479

High

744264

RRP12
Ribosomal RNA-processing protein 12

1

3

High-throughput

0.479

High

744266

NOP14
Nucleolar complex protein 14

1

3

High-throughput

0.479

High

697639

FADH
S-(hydroxymethyl)glutathione dehydrogenase

1

2

High-throughput

0.470

High

744253

NOP8
60S ribosome subunit biogenesis protein NOP8

1

0

High-throughput

0.458

High

366162

HSP82
ATP-dependent molecular chaperone HSP82

1

10

High-throughput

0.445

High

424474

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

490976

HSP71
Heat shock protein SSA1

1

18

High-throughput

0.445

High

555987

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.445

High

605014

XRN1
5'-3' exoribonuclease 1

1

5

High-throughput

0.445

High

680641

HS104
Heat shock protein 104

1

3

High-throughput

0.445

High

408337

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

6

High-throughput

0.437

High

471013

RS22A
Small ribosomal subunit protein uS8A

1

9

High-throughput

0.437

High

472153

RL31A
Large ribosomal subunit protein eL31A

1

13

High-throughput

0.437

High

481013

RL23B
Large ribosomal subunit protein uL14B

1

2

High-throughput

0.437

High

482225

RS18A
Small ribosomal subunit protein uS13A

1

7

High-throughput

0.437

High

526996

TBP
TATA-box-binding protein

1

3

High-throughput

0.437

High

613680

RS3A2
Small ribosomal subunit protein eS1B

1

10

High-throughput

0.437

High

627948

SIS1
Protein SIS1

1

7

High-throughput

0.437

High

662000

TF2B
Transcription initiation factor IIB

1

8

High-throughput

0.437

High

688206

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

5

High-throughput

0.437

High

700364

RSSA1
Small ribosomal subunit protein uS2A

1

15

High-throughput

0.437

High

704326

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

3

High-throughput

0.437

High

742751

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.437

High

744183

AIM4
Altered inheritance of mitochondria protein 4

1

1

High-throughput

0.437

High

744186

RS20
Small ribosomal subunit protein uS10

1

9

High-throughput

0.437

High

744192

LAA1
AP-1 accessory protein LAA1

1

7

High-throughput

0.437

High

744200

ULP2
Ubiquitin-like-specific protease 2

1

7

High-throughput

0.437

High

744205

SAD1
Pre-mRNA-splicing factor SAD1

1

14

High-throughput

0.437

High

744208

RS12
Small ribosomal subunit protein eS12

1

6

High-throughput

0.437

High

744214

LSG1
Large subunit GTPase 1

1

14

High-throughput

0.437

High

744216

EIF2A
Eukaryotic translation initiation factor 2A

1

6

High-throughput

0.437

High

744225

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.437

High

744226

H3
Histone H3

1

17

High-throughput

0.437

High

744235

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

744242

YM91
Putative methyltransferase YMR310C

1

3

High-throughput

0.437

High

744248

VAM6
Vacuolar morphogenesis protein 6

1

6

High-throughput

0.437

High

744254

SGO1
Shugoshin

1

5

High-throughput

0.437

High

744263

RL21B
Large ribosomal subunit protein eL21B

1

3

High-throughput

0.437

High

743501

HMT1
Protein arginine N-methyltransferase 1

1

7

High-throughput

0.417

High

367978

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.407

High

376755

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

10

High-throughput

0.407

High

744191

CAJ1
Protein CAJ1

1

6

High-throughput

0.407

High

744209

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

4

High-throughput

0.407

High

744210

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

4

High-throughput

0.407

High

502985

SEC7
Protein transport protein SEC7

2

0

High-throughput

0.307

High

744236

INP2
Inheritance of peroxisomes protein 2

2

0

High-throughput

0.307

High

686145

MET22
3'(2'),5'-bisphosphate nucleotidase

1

0

High-throughput

0.269

Low

744212

YGO0
Uncharacterized membrane protein YGL140C

1

0

High-throughput

0.249

Low

744195

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.232

Low

744211

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024