Protein: ECI2
Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1)

Gene: ECI2
Organism: Homo sapiens
Interactions: 134
UniProt ID: O75521

Gene Ontology (top 5):
GO:0000062 - fatty-acyl-CoA binding
GO:0004165 - delta(3)-delta(2)-enoyl-CoA isomerase activity
GO:0005739 - mitochondrion
GO:0005777 - peroxisome
GO:0005782 - peroxisomal matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

284568

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

5

18

High-throughput

0.927

High

284516

ECI2
Enoyl-CoA delta isomerase 2

2

17

High-throughput

0.754

High

284575

MK06
Mitogen-activated protein kinase 6

3

4

High-throughput

0.675

High

284569

TRAF1
TNF receptor-associated factor 1

3

5

Small-scale

0.667

High

284627

DBNL
Drebrin-like protein

3

2

High-throughput

0.667

High

284552

PEX5
Peroxisomal targeting signal 1 receptor

3

7

Small-scale

0.631

High

284570

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

17

High-throughput

0.618

High

284519

HERC2
E3 ubiquitin-protein ligase HERC2

2

7

Small-scale

0.611

High

284530

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

2

8

High-throughput

0.611

High

284564

UBE3A
Ubiquitin-protein ligase E3A

2

6

Small-scale

0.611

High

284603

NEUL4
Neuralized-like protein 4

2

1

Small-scale

0.611

High

284634

TNPO3
Transportin-3

2

2

High-throughput

0.606

High

284585

KANL1
KAT8 regulatory NSL complex subunit 1

2

0

High-throughput

0.602

High

284604

PRIPO
DNA-directed primase/polymerase protein

2

0

High-throughput

0.602

High

284628

FBXL5
F-box/LRR-repeat protein 5

2

0

High-throughput

0.602

High

284535

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.601

High

284623

ACS2L
Acetyl-coenzyme A synthetase 2-like, mitochondrial

1

0

High-throughput

0.586

High

279590

CISY
Citrate synthase, mitochondrial

2

7

High-throughput

0.584

High

284626

ZRAN1
Ubiquitin thioesterase ZRANB1

2

7

High-throughput

0.584

High

284607

MA7D2
MAP7 domain-containing protein 2

2

6

High-throughput

0.574

High

284609

TR61B
tRNA

2

3

High-throughput

0.571

High

284579

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

2

High-throughput

0.558

High

248643

PEPL
Periplakin

1

3

High-throughput

0.536

High

284541

XPA
DNA repair protein complementing XP-A cells

1

2

High-throughput

0.536

High

284554

RM12
Large ribosomal subunit protein bL12m

1

1

High-throughput

0.536

High

284587

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

284631

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

2

High-throughput

0.536

High

284529

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

9

High-throughput

0.515

High

284599

S67A1
Solute carrier family 67 member A1

1

2

High-throughput

0.515

High

284525

TNNC2
Troponin C, skeletal muscle

1

0

High-throughput

0.513

High

284590

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

284528

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

155984

SOCS6
Suppressor of cytokine signaling 6

1

0

High-throughput

0.493

High

284544

RADI
Radixin

1

2

High-throughput

0.489

High

284563

HSF2
Heat shock factor protein 2

1

1

High-throughput

0.489

High

284619

Z286A
Zinc finger protein 286A

1

1

High-throughput

0.489

High

122452

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

1

High-throughput

0.479

High

156773

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

274949

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

281837

MPPB
Mitochondrial-processing peptidase subunit beta

1

5

High-throughput

0.479

High

283732

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

2

High-throughput

0.479

High

284522

SNAI1
Zinc finger protein SNAI1

1

4

High-throughput

0.479

High

284526

CATA
Catalase

1

1

High-throughput

0.479

High

284531

MET
Hepatocyte growth factor receptor

1

2

High-throughput

0.479

High

284532

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

3

High-throughput

0.479

High

284534

CH60
60 kDa heat shock protein, mitochondrial

1

6

High-throughput

0.479

High

284536

ENPL
Endoplasmin

1

2

High-throughput

0.479

High

284537

IDE
Insulin-degrading enzyme

1

5

High-throughput

0.479

High

284546

MDHM
Malate dehydrogenase, mitochondrial

1

9

High-throughput

0.479

High

284547

EFTS
Elongation factor Ts, mitochondrial

1

4

High-throughput

0.479

High

284548

IF2M
Translation initiation factor IF-2, mitochondrial

1

6

High-throughput

0.479

High

284550

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

284559

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

284560

TFAM
Transcription factor A, mitochondrial

1

4

High-throughput

0.479

High

284561

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.479

High

284565

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

3

High-throughput

0.479

High

284566

MPPA
Mitochondrial-processing peptidase subunit alpha

1

5

High-throughput

0.479

High

284567

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

6

High-throughput

0.479

High

284571

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

284572

PDK1
[Pyruvate dehydrogenase

1

7

High-throughput

0.479

High

284576

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

4

High-throughput

0.479

High

284581

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

284582

MRM1
rRNA methyltransferase 1, mitochondrial

1

3

High-throughput

0.479

High

284586

DHB13
17-beta-hydroxysteroid dehydrogenase 13

1

3

High-throughput

0.479

High

284589

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

284592

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

284598

FAKD4
FAST kinase domain-containing protein 4

1

7

High-throughput

0.479

High

284605

EFGM
Elongation factor G, mitochondrial

1

6

High-throughput

0.479

High

284606

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

2

High-throughput

0.479

High

284615

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

284616

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

284617

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

8

High-throughput

0.479

High

284622

ANLN
Anillin

1

2

High-throughput

0.479

High

284625

MRES1
Mitochondrial transcription rescue factor 1

1

2

High-throughput

0.479

High

284629

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.479

High

284633

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.479

High

284539

H12
Histone H1.2

1

2

High-throughput

0.470

High

284562

H11
Histone H1.1

1

2

High-throughput

0.470

High

246345

KDM1A
Lysine-specific histone demethylase 1A

1

2

High-throughput

0.464

High

284520

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

284521

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

284523

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.458

High

284600

EF2KT
Protein-lysine N-methyltransferase EEF2KMT

1

0

High-throughput

0.458

High

284527

K2C6B
Keratin, type II cytoskeletal 6B

1

2

High-throughput

0.445

High

284540

K2C4
Keratin, type II cytoskeletal 4

1

2

High-throughput

0.445

High

284553

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

3

High-throughput

0.445

High

284556

GALC
Galactocerebrosidase

1

1

High-throughput

0.445

High

284557

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

284578

ACTBL
Beta-actin-like protein 2

1

2

High-throughput

0.445

High

284583

K2C80
Keratin, type II cytoskeletal 80

1

3

High-throughput

0.445

High

284588

NKAP
NF-kappa-B-activating protein

1

1

High-throughput

0.445

High

284591

ARI1B
AT-rich interactive domain-containing protein 1B

1

3

High-throughput

0.445

High

284594

TFG
Protein TFG

1

2

High-throughput

0.445

High

284597

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

High-throughput

0.445

High

284601

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

4

High-throughput

0.445

High

284602

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

5

High-throughput

0.445

High

284610

RM20
Large ribosomal subunit protein bL20m

1

1

High-throughput

0.445

High

284618

AGO3
Protein argonaute-3

1

2

High-throughput

0.445

High

284621

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

1

High-throughput

0.445

High

284630

S45A2
Membrane-associated transporter protein

1

1

High-throughput

0.445

High

284635

SNX9
Sorting nexin-9

1

2

High-throughput

0.445

High

284524

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

284533

H14
Histone H1.4

1

2

High-throughput

0.437

High

284538

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

284543

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

284545

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

284558

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

284584

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

284613

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.437

High

284614

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

174867

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.426

High

284549

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.426

High

284577

TYSD1
Peroxisomal leader peptide-processing protease

1

0

Small-scale

0.426

High

284611

S19A3
Thiamine transporter 2

1

0

High-throughput

0.426

High

71046

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

2

High-throughput

0.407

High

123205

PDLI1
PDZ and LIM domain protein 1

1

2

High-throughput

0.407

High

154593

ARI1A
AT-rich interactive domain-containing protein 1A

1

3

High-throughput

0.407

High

284518

VENTX
Homeobox protein VENTX

1

5

High-throughput

0.407

High

284542

ZA2G
Zinc-alpha-2-glycoprotein

1

3

High-throughput

0.407

High

284574

MEA1
Male-enhanced antigen 1

1

1

High-throughput

0.407

High

284580

SKT
Sickle tail protein homolog

1

2

High-throughput

0.407

High

284595

DPF3
Zinc finger protein DPF3

1

3

High-throughput

0.407

High

284596

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

4

High-throughput

0.407

High

284608

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.407

High

284632

TR150
Thyroid hormone receptor-associated protein 3

1

1

High-throughput

0.407

High

284612

PDGFD
Platelet-derived growth factor D

2

0

High-throughput

0.328

High

284573

CART

1

0

High-throughput

0.279

Low

284620

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

284624

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

284517

RMXL2
RNA-binding motif protein, X-linked-like-2

1

0

High-throughput

0.232

Low

284551

YLPM1
YLP motif-containing protein 1

1

0

High-throughput

0.232

Low

284555

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.232

Low

284593

POF1B
Protein POF1B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025