HitPredict

Interactor 1: MYO1C (O00159)
Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)
Gene: MYO1C

Interactor 2: SRC8 (Q14247)
Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Gene: CTTN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005938 - cell cortex GO:0051015 - actin filament binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1063 Hs			1 550
+	Hs
		214577 MYO1B_HUMAN (46-1058): 0: 1058: 39.77		SRC8_HUMAN (1-550): 0: 559: 100.00
+	Hs
		1052360 MYO5A_HUMAN (11-1020): 0: 1049: 28.73		SRC8_HUMAN (1-550): 0: 559: 100.00
+	Hs
		724825 MYH9_HUMAN (5-974): 0: 994: 29.37		SRC8_HUMAN (1-550): 0: 559: 100.00
+	Hs
		117681 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		MYO1E_HUMAN (165-549): 3.1e-44: 170: 15.01
+	Hs
		117691 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12
+	Hs
		117700 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		LASP1_HUMAN (358-547): 4.29e-13: 71.4: 22.93
+	Hs
		117537 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		SRBS2_HUMAN (447-549): 1.56e-11: 69.2: 21.91
+	Hs
		522612 MYH7_HUMAN (4-1060): 0: 1068: 27.29		SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12
+	Hs
		724801 MYH9_HUMAN (5-974): 0: 994: 29.37		MYO1E_HUMAN (165-549): 3.1e-44: 170: 15.01
+	Hs
		724817 MYH9_HUMAN (5-974): 0: 994: 29.37		SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12
+	Hs
		298957 MYH9_HUMAN (5-974): 0: 994: 29.37		SRBS2_HUMAN (447-549): 1.56e-11: 69.2: 21.91
+	Sp
		999951 MYO1_SCHPO (29-768): 1.77e-176: 550: 39.89		CDC15_SCHPO (210-549): 3.77e-31: 130: 18.56