HitPredict

Interactor 1: CDK4 (Q32KY4)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4)
Gene: CDK4

Interactor 2: PCNA (Q3ZBW4)
Proliferating cell nuclear antigen (PCNA)
Gene: PCNA

Species: Bos taurus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9396813
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 303 Bt			1 261
+	Bt
		1191826 CDK2_BOVIN (3-301): 1.26e-144: 410: 43.89		PCNA_BOVIN (1-261): 1.23e-126: 361: 100.00
+	Hs
		550850 CDK2_HUMAN (3-301): 6.11e-145: 411: 44.22		PCNA_HUMAN (1-261): 4.02e-126: 360: 99.23
+	Mm
		609535 CDK2_MOUSE (3-301): 1.43e-135: 389: 37.89		PCNA_MOUSE (1-261): 2.09e-127: 363: 96.94
+	Hs
		443144 CDK1_HUMAN (3-300): 1.92e-129: 372: 42.24		PCNA_HUMAN (1-261): 4.02e-126: 360: 99.23
+	Hs
		550987 CDK6_HUMAN (5-298): 1.89e-127: 367: 69.83		PCNA_HUMAN (1-261): 4.02e-126: 360: 99.23
+	Hs
		549035 CDK4_HUMAN (1-303): 2.81e-127: 366: 97.03		PCNA_HUMAN (1-261): 4.02e-126: 360: 99.23
+	Mm
		609528 CDK4_MOUSE (1-303): 8.06e-126: 362: 95.05		PCNA_MOUSE (1-261): 2.09e-127: 363: 96.94
+	Bt
		1036641 CDK5_BOVIN (3-301): 4.82e-124: 357: 43.42		PCNA_BOVIN (1-261): 1.23e-126: 361: 100.00
+	Hs
		550988 CDK5_HUMAN (3-301): 4.41e-124: 358: 43.42		PCNA_HUMAN (1-261): 4.02e-126: 360: 99.23