Protein: CDK6
Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)

Gene: CDK6
Organism: Homo sapiens
Interactions: 218
UniProt ID: Q00534

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0001726 - ruffle
GO:0001954 - positive regulation of cell-matrix adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

718882

CCND3
G1/S-specific cyclin-D3

25

20

Small-scale

0.993

High

842952

CDN2C
Cyclin-dependent kinase 4 inhibitor C

21

17

Small-scale

0.991

High

842907

CDN2B
Cyclin-dependent kinase 4 inhibitor B

12

16

Small-scale

0.986

High

937461

CDN2D
Cyclin-dependent kinase 4 inhibitor D

14

17

Small-scale

0.986

High

664709

CCND1
G1/S-specific cyclin-D1

16

20

Small-scale

0.983

High

857310

CDN1B
Cyclin-dependent kinase inhibitor 1B

9

20

Small-scale

0.970

High

808022

CDN1A
Cyclin-dependent kinase inhibitor 1

7

20

Small-scale

0.963

High

718802

CCND2
G1/S-specific cyclin-D2

7

20

Small-scale

0.962

High

1025358

CDC37
Hsp90 co-chaperone Cdc37

6

7

Small-scale

0.942

High

892749

CDN1C
Cyclin-dependent kinase inhibitor 1C

4

20

Small-scale

0.895

High

468268

HS90B
Heat shock protein HSP 90-beta

4

20

Small-scale

0.887

High

549119

CDK4
Cyclin-dependent kinase 4

3

16

High-throughput

0.866

High

251568

CCNT1
Cyclin-T1

3

20

High-throughput

0.861

High

252241

CCNT2
Cyclin-T2

3

20

High-throughput

0.861

High

1025414

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

3

20

High-throughput

0.861

High

354667

PAK4
Serine/threonine-protein kinase PAK 4

2

11

High-throughput

0.811

High

1025338

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

13

High-throughput

0.811

High

908692

CCNH
Cyclin-H

2

20

High-throughput

0.783

High

1025341

CCNI
Cyclin-I

2

20

High-throughput

0.783

High

842727

CDN2A
Cyclin-dependent kinase inhibitor 2A

21

16

Small-scale

0.768

High

666974

CCNE1
G1/S-specific cyclin-E1

2

20

Small-scale

0.768

High

1025319

CDK6
Cyclin-dependent kinase 6

2

16

High-throughput

0.768

High

442670

RB
Retinoblastoma-associated protein

11

20

Small-scale

0.756

High

461362

HS90A
Heat shock protein HSP 90-alpha

2

20

Small-scale

0.754

High

320553

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

1

4

Small-scale

0.724

High

1025409

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

3

Small-scale

0.724

High

1025364

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.712

High

290916

PPM1B
Protein phosphatase 1B

1

7

Small-scale

0.710

High

704466

MZF1
Myeloid zinc finger 1

1

1

Small-scale

0.710

High

988085

TRA2B
Transformer-2 protein homolog beta

1

6

Small-scale

0.710

High

1025323

SRSF2
Serine/arginine-rich splicing factor 2

1

3

Small-scale

0.710

High

1025328

SRS11
Serine/arginine-rich splicing factor 11

1

3

Small-scale

0.710

High

1025329

SRSF1
Serine/arginine-rich splicing factor 1

1

6

Small-scale

0.710

High

1025333

KLF10
Krueppel-like factor 10

1

4

Small-scale

0.710

High

1025340

TRA2A
Transformer-2 protein homolog alpha

1

10

Small-scale

0.710

High

1025354

ZN174
Zinc finger protein 174

1

2

Small-scale

0.710

High

1025359

SRSF7
Serine/arginine-rich splicing factor 7

1

7

Small-scale

0.710

High

1025372

ANR12
Ankyrin repeat domain-containing protein 12

1

10

Small-scale

0.710

High

1025381

RBM23
Probable RNA-binding protein 23

1

7

Small-scale

0.710

High

1025385

ZN101
Zinc finger protein 101

1

4

Small-scale

0.710

High

1025390

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

3

Small-scale

0.710

High

1025395

SNIP1
Smad nuclear-interacting protein 1

1

1

Small-scale

0.710

High

1025396

SRS12
Serine/arginine-rich splicing factor 12

1

6

Small-scale

0.710

High

1025397

DEDD2
DNA-binding death effector domain-containing protein 2

1

1

Small-scale

0.710

High

1025424

BC11A
BCL11 transcription factor A

1

3

Small-scale

0.710

High

1025426

ZN335
Zinc finger protein 335

1

1

Small-scale

0.710

High

1025438

TPX2
Targeting protein for Xklp2

1

2

Small-scale

0.710

High

1025320

CDK5
Cyclin-dependent kinase 5

1

18

High-throughput

0.691

High

1025383

CDKL3
Cyclin-dependent kinase-like 3

1

18

High-throughput

0.691

High

1025407

PPM1M
Protein phosphatase 1M

1

10

High-throughput

0.691

High

790023

ZEB1
Zinc finger E-box-binding homeobox 1

1

0

Small-scale

0.674

High

1025433

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.674

High

1025404

UBE2W
Ubiquitin-conjugating enzyme E2 W

3

2

High-throughput

0.667

High

378977

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.656

High

400659

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.647

High

410774

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

14

High-throughput

0.647

High

472040

MET
Hepatocyte growth factor receptor

1

11

High-throughput

0.647

High

521311

ARAF
Serine/threonine-protein kinase A-Raf

1

20

High-throughput

0.647

High

593337

PGFRA
Platelet-derived growth factor receptor alpha

1

12

High-throughput

0.647

High

648485

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.647

High

710175

EPHA2
Ephrin type-A receptor 2

1

11

High-throughput

0.647

High

728173

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

High-throughput

0.647

High

858631

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

20

High-throughput

0.647

High

897236

CDK7
Cyclin-dependent kinase 7

1

17

Small-scale

0.647

High

1025335

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

20

High-throughput

0.647

High

1025355

STK11
Serine/threonine-protein kinase STK11

1

15

High-throughput

0.647

High

1025357

MK14
Mitogen-activated protein kinase 14

1

19

High-throughput

0.647

High

1025391

GLIS1
Zinc finger protein GLIS1

1

8

High-throughput

0.647

High

1025411

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

16

High-throughput

0.647

High

1025420

GLIS2
Zinc finger protein GLIS2

1

8

High-throughput

0.647

High

1025430

LATS2
Serine/threonine-protein kinase LATS2

1

12

High-throughput

0.647

High

1025431

RASF1
Ras association domain-containing protein 1

1

8

High-throughput

0.647

High

1025382

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

2

3

High-throughput

0.628

High

371775

MYC
Myc proto-oncogene protein

2

6

Small-scale

0.625

High

247295

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

6

High-throughput

0.618

High

411744

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

573434

ENPL
Endoplasmin

1

20

Small-scale

0.618

High

578455

BRAF
Serine/threonine-protein kinase B-raf

1

20

High-throughput

0.618

High

612975

EGR1
Early growth response protein 1

1

2

High-throughput

0.618

High

629101

CCNA2
Cyclin-A2

1

20

Small-scale

0.618

High

1025322

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

8

Small-scale

0.618

High

1025327

FAK1
Focal adhesion kinase 1

1

18

Small-scale

0.618

High

1025351

CD5R1
Cyclin-dependent kinase 5 activator 1

1

8

Small-scale

0.618

High

1025363

LARP7
La-related protein 7

1

10

High-throughput

0.618

High

1025374

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.618

High

1025410

Q96TE0
Cyclin-dependent kinase inhibitor 1B

1

20

Small-scale

0.618

High

1025324

RUNX1
Runt-related transcription factor 1

2

4

Small-scale

0.611

High

834140

ABEC1
C->U-editing enzyme APOBEC-1

2

1

High-throughput

0.606

High

1025367

OTP
Homeobox protein orthopedia

2

6

High-throughput

0.606

High

1025421

TRI15
E3 ubiquitin-protein ligase TRIM15

2

4

High-throughput

0.606

High

1025326

H11
Histone H1.1

2

20

Small-scale

0.602

High

1025401

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.589

High

286359

DAB1
Disabled homolog 1

2

6

Small-scale

0.586

High

1025408

ZN363
RING finger and CHY zinc finger domain-containing protein 1

2

0

High-throughput

0.585

High

1025371

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

9

Small-scale

0.578

High

1025375

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

7

Small-scale

0.578

High

295571

CIB2
Calcium and integrin-binding family member 2

1

3

High-throughput

0.575

High

596555

ZN823
Zinc finger protein 823

1

2

Small-scale

0.575

High

667778

CDK2
Cyclin-dependent kinase 2

1

14

Small-scale

0.575

High

1025365

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

High-throughput

0.575

High

183448

CASC3
Protein CASC3

1

1

Small-scale

0.550

High

219720

FOXO3
Forkhead box protein O3

1

12

Small-scale

0.550

High

622438

ELK1
ETS domain-containing protein Elk-1

1

1

Small-scale

0.550

High

704942

RBL1
Retinoblastoma-like protein 1

1

20

Small-scale

0.550

High

714035

PML
Protein PML

1

10

Small-scale

0.550

High

776053

SOX5
Transcription factor SOX-5

1

9

Small-scale

0.550

High

839879

AF9
Protein AF-9

1

5

Small-scale

0.550

High

942091

SOX10
Transcription factor SOX-10

1

13

Small-scale

0.550

High

961477

ISL1
Insulin gene enhancer protein ISL-1

1

4

Small-scale

0.550

High

994179

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

15

Small-scale

0.550

High

1010745

SSBP2
Single-stranded DNA-binding protein 2

1

2

Small-scale

0.550

High

1025321

HSF1
Heat shock factor protein 1

1

8

Small-scale

0.550

High

1025330

FOXM1
Forkhead box protein M1

1

7

Small-scale

0.550

High

1025331

RBL2
Retinoblastoma-like protein 2

1

20

Small-scale

0.550

High

1025332

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

1

9

Small-scale

0.550

High

1025344

TFDP1
Transcription factor Dp-1

1

9

Small-scale

0.550

High

1025347

SLBP
Histone RNA hairpin-binding protein

1

3

Small-scale

0.550

High

1025348

LPIN1
Phosphatidate phosphatase LPIN1

1

1

Small-scale

0.550

High

1025349

MEF2D
Myocyte-specific enhancer factor 2D

1

7

Small-scale

0.550

High

1025350

NUMA1
Nuclear mitotic apparatus protein 1

1

14

Small-scale

0.550

High

1025356

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

Small-scale

0.550

High

1025368

NIPBL
Nipped-B-like protein

1

15

Small-scale

0.550

High

1025384

ELOA2
Elongin-A2

1

3

Small-scale

0.550

High

1025387

CLASR
CLK4-associating serine/arginine rich protein

1

2

Small-scale

0.550

High

1025405

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

7

Small-scale

0.550

High

1025412

CDC6
Cell division control protein 6 homolog

1

12

Small-scale

0.550

High

1025413

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

4

Small-scale

0.550

High

1025416

SRBS1
Sorbin and SH3 domain-containing protein 1

1

2

Small-scale

0.550

High

1025417

PRAX
Periaxin

1

7

Small-scale

0.550

High

1025425

SENP3
Sentrin-specific protease 3

1

3

Small-scale

0.550

High

1025434

ZO2
Tight junction protein 2

1

2

Small-scale

0.550

High

1025440

SYNP2
Synaptopodin-2

1

1

Small-scale

0.550

High

1025441

TRAK1
Trafficking kinesin-binding protein 1

1

15

Small-scale

0.550

High

927235

ATX1
Ataxin-1

1

3

High-throughput

0.541

High

887977

MCM2
DNA replication licensing factor MCM2

1

9

High-throughput

0.536

High

1025377

MCM10
Protein MCM10 homolog

1

1

High-throughput

0.536

High

361221

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

550987

PCNA
Proliferating cell nuclear antigen

1

9

High-throughput

0.536

High

992565

IF5A1
Eukaryotic translation initiation factor 5A-1

1

2

High-throughput

0.536

High

1025366

BSPRY
B box and SPRY domain-containing protein

1

5

High-throughput

0.536

High

1025370

KLC3
Kinesin light chain 3

1

5

High-throughput

0.536

High

1025403

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1025422

WDR33
pre-mRNA 3' end processing protein WDR33

1

8

High-throughput

0.536

High

1025427

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

2

High-throughput

0.536

High

1025428

E41L5
Band 4.1-like protein 5

1

8

High-throughput

0.536

High

1025436

DMBT1
Scavenger receptor cysteine-rich domain-containing protein DMBT1

1

1

High-throughput

0.536

High

270716

N4BP1
NEDD4-binding protein 1

1

0

Small-scale

0.527

High

775410

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.527

High

1025342

VGLL4
Transcription cofactor vestigial-like protein 4

1

0

Small-scale

0.527

High

1025345

ZMYM3
Zinc finger MYM-type protein 3

1

0

Small-scale

0.527

High

1025379

POGZ
Pogo transposable element with ZNF domain

1

0

Small-scale

0.527

High

1025389

MS3L1
MSL complex subunit 3

1

0

Small-scale

0.527

High

1025393

PPHLN
Periphilin-1

1

0

Small-scale

0.527

High

1025415

COE4
Transcription factor COE4

1

0

Small-scale

0.527

High

1025429

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

Small-scale

0.527

High

1025443

CBY1
Protein chibby homolog 1

1

0

Small-scale

0.527

High

488454

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

7

Small-scale

0.515

High

1025380

PEG10
Retrotransposon-derived protein PEG10

1

0

High-throughput

0.513

High

1025444

NEUR2
Sialidase-2

1

0

High-throughput

0.513

High

162934

TERT
Telomerase reverse transcriptase

1

1

High-throughput

0.501

High

413629

P53
Cellular tumor antigen p53

1

7

High-throughput

0.501

High

591276

CD44
CD44 antigen

1

2

High-throughput

0.501

High

688228

TTP
mRNA decay activator protein ZFP36

1

4

Small-scale

0.501

High

693290

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

8

High-throughput

0.501

High

767168

MERL
Merlin

1

8

High-throughput

0.501

High

991290

SUMO1
Small ubiquitin-related modifier 1

1

3

Small-scale

0.501

High

1025336

GRM1
Metabotropic glutamate receptor 1

1

3

High-throughput

0.501

High

1025343

KEAP1
Kelch-like ECH-associated protein 1

1

1

High-throughput

0.501

High

1025346

BECN1
Beclin-1

1

1

High-throughput

0.501

High

1025353

TEAD2
Transcriptional enhancer factor TEF-4

1

1

High-throughput

0.501

High

1025360

HIF1A
Hypoxia-inducible factor 1-alpha

1

7

High-throughput

0.501

High

1025361

KI26B
Kinesin-like protein KIF26B

1

6

Small-scale

0.501

High

1025399

TSC1
Hamartin

1

12

High-throughput

0.501

High

1025400

KAT2A
Histone acetyltransferase KAT2A

1

10

High-throughput

0.501

High

1025432

ABI2
Abl interactor 2

1

3

Small-scale

0.501

High

1025439

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.501

High

681339

PSA3
Proteasome subunit alpha type-3

1

6

High-throughput

0.481

High

1025437

CBLC
E3 ubiquitin-protein ligase CBL-C

1

0

High-throughput

0.480

High

247828

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

324794

HEXI1
Protein HEXIM1

1

5

High-throughput

0.479

High

556015

CADH1
Cadherin-1

1

3

Small-scale

0.479

High

588477

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

764664

CTNB1
Catenin beta-1

1

10

Small-scale

0.479

High

791294

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

957711

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

4

Small-scale

0.479

High

970342

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

993496

UBC9
SUMO-conjugating enzyme UBC9

1

4

Small-scale

0.479

High

1025325

RELB
Transcription factor RelB

1

8

Small-scale

0.479

High

1025334

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

9

High-throughput

0.479

High

1025337

TIF1B
Transcription intermediary factor 1-beta

1

9

High-throughput

0.479

High

1025339

SMAD4
Mothers against decapentaplegic homolog 4

1

4

High-throughput

0.479

High

1025352

IRF4
Interferon regulatory factor 4

1

2

Small-scale

0.479

High

1025362

EMAL3
Echinoderm microtubule-associated protein-like 3

1

3

High-throughput

0.479

High

1025376

MOB3C
MOB kinase activator 3C

1

4

High-throughput

0.479

High

1025378

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

1025392

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.479

High

1025394

COP1
E3 ubiquitin-protein ligase COP1

1

6

High-throughput

0.479

High

1025398

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

1025402

FBXW7
F-box/WD repeat-containing protein 7

1

9

High-throughput

0.479

High

1025406

EGLN2
Prolyl hydroxylase EGLN2

1

6

Small-scale

0.479

High

1025419

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1025423

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.479

High

1025435

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1025373

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1025418

RTF2
Replication termination factor 2

1

0

High-throughput

0.458

High

1025442

FBX7
F-box only protein 7

1

0

Small-scale

0.458

High

571191

HGF
Hepatocyte growth factor

1

1

High-throughput

0.457

High

622586

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

High-throughput

0.457

High

755472

ERD22
ER lumen protein-retaining receptor 2

1

1

High-throughput

0.457

High

1025369

ARMC6
Armadillo repeat-containing protein 6

1

1

High-throughput

0.445

High

1025386

ABI1
Abl interactor 1

1

4

Small-scale

0.445

High

1025388

CAHM5
Calcium homeostasis modulator protein 5

2

0

High-throughput

0.319

High

261152

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.279

Low

415142

AMYP
Pancreatic alpha-amylase

1

0

High-throughput

0.279

Low

652630

CAH4
Carbonic anhydrase 4

1

0

High-throughput

0.279

Low

342538

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.232

Low

628402

KLK2
Kallikrein-2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025