HitPredict

Interactor 1: AIP (O00170)
AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9)
Gene: AIP

Interactor 2: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	32707033, 36244648, 38496616
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 330 Hs			1 648
+	Hs
		374114 PPID_HUMAN (16-329): 5.75e-64: 208: 17.21		RAF1_HUMAN (1-648): 0: 652: 100.00
+	Hs
		374182 FKBP5_HUMAN (5-330): 6.89e-57: 192: 15.20		RAF1_HUMAN (1-648): 0: 652: 100.00
+	Hs
		374083 FKBP4_HUMAN (9-330): 4.49e-55: 187: 18.89		RAF1_HUMAN (1-648): 0: 652: 100.00
+	Hs
		375059 FKBPL_HUMAN (114-329): 3.41e-40: 146: 22.32		RAF1_HUMAN (1-648): 0: 652: 100.00
+	Hs
		118681 AIP_HUMAN (1-330): 2.25e-86: 264: 100.00		ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28
+	Hs
		374290 TOM34_HUMAN (177-302): 2.66e-15: 77.2: 23.81		RAF1_HUMAN (1-648): 0: 652: 100.00
+	Gg
		982843 Q646T7_CHICK (5-330): 3.99e-59: 198: 16.41		BRAF_CHICK (38-647): 1.98e-169: 504: 56.96
+	Hs
		542876 FKBP5_HUMAN (5-330): 6.89e-57: 192: 15.20		BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88
+	Hs
		488708 FKBP5_HUMAN (5-330): 6.89e-57: 192: 15.20		ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28
+	Hs
		488688 FKBP4_HUMAN (9-330): 4.49e-55: 187: 18.89		ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28
+	Hs
		488716 FKBP8_HUMAN (6-330): 4.65e-55: 186: 17.23		ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28
+	Hs
		542932 FKBPL_HUMAN (114-329): 3.41e-40: 146: 22.32		BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88
+	Hs
		118683 AIP_HUMAN (1-330): 2.25e-86: 264: 100.00		SRC_HUMAN (331-607): 3.01e-106: 333: 33.45
+	Hs
		118675 AIP_HUMAN (1-330): 2.25e-86: 264: 100.00		YES_HUMAN (329-607): 1.22e-105: 332: 33.92
+	Hs
		118671 AIP_HUMAN (1-330): 2.25e-86: 264: 100.00		FYN_HUMAN (337-607): 2.33e-103: 326: 34.55
+	Hs
		1034905 FKBP5_HUMAN (5-330): 6.89e-57: 192: 15.20		KSR2_HUMAN (332-623): 6.72e-43: 168: 34.43
+	Hs
		259949 FKBP6_HUMAN (4-329): 6.96e-55: 183: 17.18		KSR2_HUMAN (332-623): 6.72e-43: 168: 34.43