HitPredict

Interactor 1: LEG9 (O00182)
Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21)
Gene: LGALS9

Interactor 2: LEG8 (O00214)
Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)
Gene: LGALS8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 17223646
Identification Methods	affinity chromatography technology, surface plasmon resonance, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Gal-bind_lectin~Gal-bind_lectin
Common GO terms	GO:0005615 - extracellular space GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030246 - carbohydrate binding GO:0098586 - cellular response to virus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 317
+	Hs
		119003 LEG9_HUMAN (1-355): 6.7e-144: 412: 100.00		LEG9_HUMAN (3-316): 1.06e-111: 329: 30.83
+	Hs
		119401 LEG9_HUMAN (1-355): 6.7e-144: 412: 100.00		LEG9B_HUMAN (3-316): 3.69e-110: 325: 30.47
+	Hs
		119417 LEG9_HUMAN (1-355): 6.7e-144: 412: 100.00		LEG9C_HUMAN (3-316): 4.69e-110: 325: 30.47
+	Mm
		139220 LEG9_MOUSE (1-355): 9.7e-137: 394: 69.30		LEG9_MOUSE (3-316): 6.48e-117: 342: 34.08
+	Hs
		121051 LEG8_HUMAN (1-355): 1.01e-104: 312: 30.85		LEG8_HUMAN (1-317): 8.73e-135: 386: 100.00
+	Hs
		119146 LEG9_HUMAN (1-355): 6.7e-144: 412: 100.00		LEG3_HUMAN (16-153): 2.84e-45: 155: 39.72
+	Hs
		572378 LEG9C_HUMAN (1-355): 6.62e-140: 402: 94.10		LEG3_HUMAN (16-153): 2.84e-45: 155: 39.72
+	Mm
		1207900 Q8C253_MOUSE (5-146): 1.36e-40: 145: 36.24		Q8C253_MOUSE (16-153): 3.02e-45: 156: 38.30
+	Mm
		555719 LEG3_MOUSE (5-146): 1.39e-40: 145: 36.24		LEG3_MOUSE (16-153): 3.19e-45: 156: 38.30
+	Hs
		572276 LEG3_HUMAN (5-147): 5.77e-41: 145: 37.33		LEG3_HUMAN (16-153): 2.84e-45: 155: 39.72
+	Ce
		736225 LEC1_CAEEL (13-148): 1.95e-35: 132: 35.29		LEC3_CAEEL (5-159): 6.19e-43: 151: 30.54
+	Ce
		736208 LEC1_CAEEL (13-148): 1.95e-35: 132: 35.29		LEC1_CAEEL (3-152): 1.42e-42: 149: 30.67
+	Hs
		814917 LEG7_HUMAN (224-354): 6.94e-39: 136: 37.04		LEG7_HUMAN (184-315): 1.04e-42: 145: 36.57
+	Hs
		449181 LEG3_HUMAN (5-147): 5.77e-41: 145: 37.33		LEG1_HUMAN (192-314): 3.25e-38: 133: 31.50
+	Ce
		736236 LEC1_CAEEL (13-148): 1.95e-35: 132: 35.29		Q20684_CAEEL (158-315): 5.22e-29: 119: 25.93
+	Ce
		736228 LEC1_CAEEL (13-148): 1.95e-35: 132: 35.29		Q18625_CAEEL (183-315): 9.95e-28: 110: 28.99