HitPredict

Interactor 1: RBBP6 (Q7Z6E9)
E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)
Gene: RBBP6

Interactor 2: ZCH18 (Q86VM9)
Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1)
Gene: ZC3H18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 29298432, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0016607 - nuclear speck GO:0032991 - protein-containing complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1792 Hs			1 953
+	Hs
		1191750 RBBP6_HUMAN (1-1792): 1.97e-152: 516: 100.00		SRRM2_HUMAN (7-950): 3.04e-18: 92.9: 11.64
+	Hs
		1201616 MINT_HUMAN (76-1784): 4.28e-28: 126: 7.98		ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00
+	Hs
		1201807 PRC2C_HUMAN (87-1452): 1.6e-12: 75.4: 8.27		ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00
+	Hs
		230386 ZC3H1_HUMAN (679-1650): 2.57e-10: 68: 12.68		ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00
+	Dm
		1376672 FUTSC_DROME (371-1792): 9.87e-21: 102: 11.61		FUTSC_DROME (3-953): 6.99e-26: 117: 12.14
+	Dm
		113976 M9PB30_DROME (259-1062): 5.51e-26: 120: 9.10		M9PB30_DROME (374-952): 2.15e-16: 87.1: 7.48
+	Dm
		65570 A8JNM5_DROME (946-1563): 6.14e-11: 70.3: 16.98		FUTSC_DROME (3-953): 6.99e-26: 117: 12.14
+	Hs
		1056563 MDC1_HUMAN (508-1516): 4.61e-24: 113: 10.37		TRIPC_HUMAN (539-925): 2.98e-10: 66.6: 17.28
+	Hs
		1056827 MDC1_HUMAN (508-1516): 4.61e-24: 113: 10.37		MDC1_HUMAN (9-950): 1.49e-09: 64.4: 9.73
+	Mm
		1351630 PCLO_MOUSE (276-1782): 2.57e-09: 65: 8.17		PCLO_MOUSE (336-952): 4.64e-24: 112: 9.12
+	Dm
		54892 Q9VLS7_DROME (382-1689): 4.6e-21: 103: 7.43		A1ZA72_DROME (31-927): 3.65e-10: 66.6: 13.85
+	Hs
		152668 BD1L1_HUMAN (851-1782): 4.77e-20: 100: 13.46		KMT2D_HUMAN (379-947): 6.05e-11: 69: 11.30
+	Dm
		1366600 Q9VLS7_DROME (382-1689): 4.6e-21: 103: 7.43		Q9VH10_DROME (5-915): 1.66e-09: 64.3: 8.72
+	Hs
		1056897 BD1L1_HUMAN (851-1782): 4.77e-20: 100: 13.46		MDC1_HUMAN (9-950): 1.49e-09: 64.4: 9.73
+	Hs
		1264771 TITIN_HUMAN (79-1153): 3.14e-15: 84.6: 10.07		TITIN_HUMAN (139-952): 5.65e-14: 79: 9.54
+	Hs
		152667 KMT2C_HUMAN (88-1775): 2.2e-16: 88.1: 7.78		KMT2D_HUMAN (379-947): 6.05e-11: 69: 11.30
+	Hs
		1154038 NIPBL_HUMAN (880-1382): 5.38e-11: 70.3: 18.50		NIPBL_HUMAN (485-927): 6.3e-11: 68.9: 15.90