HitPredict

Interactor 1: MASP2 (O00187)
Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]
Gene: MASP2

Interactor 2: MASP2 (O00187)
Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]
Gene: MASP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.928

The method score is based on:

Property Details
Experiments 36100602, 11290788, 15117939, 22071314, 23785123
Identification Methods pull down, enzymatic study, cosedimentation in solution, x-ray crystallography, protease assay, solid phase assay, anti bait coimmunoprecipitation
Interaction Type direct interaction, protein cleavage, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CUB~CUB, CUB~EGF_CA, CUB~Sushi, EGF_CA~EGF_CA, Sushi~Sushi, Sushi~Trypsin, Trypsin~Trypsin
Common GO terms GO:0001855 - complement component C4b binding
GO:0001867 - complement activation, lectin pathway
GO:0004252 - serine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
and 6 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 686
Hs

1 686
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024