HitPredict

Interactor 1: GLRX5 (Q86SX6)
Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5)
Gene: GLRX5

Interactor 2: BOLA1 (Q9Y3E2)
BolA-like protein 1 (hBolA)
Gene: BOLA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.899

Property	Details
Experiments	27532772, 27499296, 27532773, 33961781
Identification Methods	pull down, affinity chromatography technology, nuclear magnetic resonance, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	BolA~Glutaredoxin
Common GO terms	GO:0005739 - mitochondrion GO:0006879 - intracellular iron ion homeostasis GO:0016226 - iron-sulfur cluster assembly GO:0045454 - cell redox homeostasis GO:1990229 - iron-sulfur cluster assembly complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 157 Hs			1 137
+	Ec
		466339 GLRX4_ECOLI (39-154): 5.49e-40: 132: 33.62		BOLA_ECOLI (32-129): 1.47e-39: 130: 44.44
+	At
		1147356 GRS15_ARATH (34-146): 2.78e-41: 137: 37.17		BOLA1_ARATH (21-113): 1.49e-33: 116: 39.39
+	At
		1196493 GRS15_ARATH (34-146): 2.78e-41: 137: 37.17		SUFE1_ARATH (21-113): 1.62e-31: 116: 37.62
+	At
		1147353 GRS14_ARATH (33-141): 6.77e-41: 136: 48.62		BOLA1_ARATH (21-113): 1.49e-33: 116: 39.39
+	At
		1196490 GRS14_ARATH (33-141): 6.77e-41: 136: 48.62		SUFE1_ARATH (21-113): 1.62e-31: 116: 37.62
+	Hs
		1121855 GLRX5_HUMAN (1-157): 5.7e-56: 174: 100.00		BOLA3_HUMAN (30-113): 2.35e-17: 73.6: 22.35
+	Dm
		53878 Q8SXQ5_DROME (42-157): 6.93e-47: 151: 64.41		A1Z933_DROME (34-116): 4.69e-26: 95.2: 33.74
+	Sc
		972476 GLRX5_YEAST (37-151): 8.59e-43: 140: 43.59		BOL1_YEAST (30-119): 6.13e-26: 96: 33.66
+	Sc
		977743 GLRX3_YEAST (40-136): 5.21e-41: 139: 41.84		BOL1_YEAST (30-119): 6.13e-26: 96: 33.66
+	At
		1227407 GRS15_ARATH (34-146): 2.78e-41: 137: 37.17		BOLA2_ARATH (31-123): 1.2e-26: 97.1: 39.36
+	At
		1196707 GRS14_ARATH (33-141): 6.77e-41: 136: 48.62		BOLA2_ARATH (31-123): 1.2e-26: 97.1: 39.36
+	Sc
		697331 GLRX4_YEAST (41-131): 4.75e-40: 136: 42.86		BOL1_YEAST (30-119): 6.13e-26: 96: 33.66
+	Sc
		858951 GLRX3_YEAST (40-136): 5.21e-41: 139: 41.84		BOL2_YEAST (28-116): 1.29e-24: 92.9: 27.78
+	Sc
		697322 GLRX4_YEAST (41-131): 4.75e-40: 136: 42.86		BOL2_YEAST (28-116): 1.29e-24: 92.9: 27.78
+	Sc
		763749 GLRX5_YEAST (37-151): 8.59e-43: 140: 43.59		BOL3_YEAST (28-109): 9.71e-22: 85.2: 30.49
+	Sc
		763750 GLRX3_YEAST (40-136): 5.21e-41: 139: 41.84		BOL3_YEAST (28-109): 9.71e-22: 85.2: 30.49
+	Ec
		465348 GLRX4_ECOLI (39-154): 5.49e-40: 132: 33.62		IBAG_ECOLI (47-121): 9.49e-25: 92.1: 27.63
+	At
		1227411 GRS15_ARATH (34-146): 2.78e-41: 137: 37.17		BOLA4_ARATH (34-113): 8.22e-21: 84.4: 33.33
+	Sc
		697320 GLRX4_YEAST (41-131): 4.75e-40: 136: 42.86		BOL3_YEAST (28-109): 9.71e-22: 85.2: 30.49
+	At
		1196708 GRS14_ARATH (33-141): 6.77e-41: 136: 48.62		BOLA4_ARATH (34-113): 8.22e-21: 84.4: 33.33