HitPredict

Interactor 1: TM11B (Q86T26)
Transmembrane protease serine 11B (EC 3.4.21.-) (Airway trypsin-like protease 5)
Gene: TMPRSS11B

Interactor 2: DCBD2 (Q96PD2)
Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein)
Gene: DCBLD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 416 Hs			1 775
+	Hs
		1299196 TMPSD_HUMAN (124-416): 1.41e-102: 318: 31.67		DCBD2_HUMAN (1-775): 0: 776: 100.00
+	Hs
		155388 TM11B_HUMAN (1-416): 0: 516: 100.00		NRP1_HUMAN (7-474): 1.9e-56: 210: 18.06
+	Hs
		1198138 TM11B_HUMAN (1-416): 0: 516: 100.00		CNT3B_HUMAN (340-451): 1.2e-12: 73.9: 33.33
+	Hs
		341156 C1R_HUMAN (42-414): 1.48e-104: 326: 21.61		C1R_HUMAN (1-582): 4.33e-60: 217: 13.51
+	Hs
		409513 HEPS_HUMAN (157-415): 4.97e-105: 318: 37.27		MFGM_HUMAN (204-616): 9.04e-66: 225: 16.71
+	Hs
		995626 TMPSD_HUMAN (124-416): 1.41e-102: 318: 31.67		MFGM_HUMAN (204-616): 9.04e-66: 225: 16.71
+	Hs
		995632 TMPS4_HUMAN (143-413): 4.83e-103: 314: 34.93		MFGM_HUMAN (204-616): 9.04e-66: 225: 16.71
+	Hs
		995634 ST14_HUMAN (168-416): 1.32e-96: 309: 36.15		MFGM_HUMAN (204-616): 9.04e-66: 225: 16.71
+	Hs
		234442 TMPSD_HUMAN (124-416): 1.41e-102: 318: 31.67		NRP2_HUMAN (4-486): 2.56e-52: 198: 16.64
+	Hs
		234451 ST14_HUMAN (168-416): 1.32e-96: 309: 36.15		NRP2_HUMAN (4-486): 2.56e-52: 198: 16.64
+	Hs
		119686 MASP1_HUMAN (40-416): 8.04e-114: 350: 24.25		MASP2_HUMAN (73-506): 1.02e-36: 149: 13.46
+	Hs
		822570 MASP1_HUMAN (40-416): 8.04e-114: 350: 24.25		MASP1_HUMAN (77-495): 1.46e-36: 148: 14.47
+	Hs
		119676 MASP2_HUMAN (37-414): 5.21e-111: 342: 22.51		MASP2_HUMAN (73-506): 1.02e-36: 149: 13.46
+	Hs
		1316671 TMPSD_HUMAN (124-416): 1.41e-102: 318: 31.67		PCOC2_HUMAN (24-188): 1.03e-37: 147: 23.43
+	Hs
		409570 HEPS_HUMAN (157-415): 4.97e-105: 318: 37.27		PCOC2_HUMAN (24-188): 1.03e-37: 147: 23.43
+	Hs
		1356682 ST14_HUMAN (168-416): 1.32e-96: 309: 36.15		PCOC2_HUMAN (24-188): 1.03e-37: 147: 23.43
+	Hs
		341377 PLMN_HUMAN (108-414): 3.11e-100: 317: 27.76		PCOC1_HUMAN (50-190): 7.75e-34: 137: 27.27
+	Hs
		341158 C1R_HUMAN (42-414): 1.48e-104: 326: 21.61		C1S_HUMAN (79-505): 6.97e-29: 125: 12.42
+	Hs
		1197863 TMPS5_HUMAN (158-415): 3.68e-101: 309: 35.99		AGRG6_HUMAN (71-184): 3.51e-14: 79: 40.34