HitPredict

Interactor 1: THOC4 (Q86V81)
THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF)
Gene: ALYREF

Interactor 2: THOC2 (Q8NI27)
THO complex subunit 2 (Tho2) (hTREX120)
Gene: THOC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.735

Property	Details
Experiments	30833792, 15998806, 17190602, 23222130, 26496610, 23299939
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000346 - transcription export complex GO:0003729 - mRNA binding GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0006406 - mRNA export from nucleus and 2 others more... GO:0008380 - RNA splicing GO:0016607 - nuclear speck
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 257 Hs			1 1593
+	Hs
		92363 E9PB61_HUMAN (1-257): 8.64e-47: 158: 100.00		THOC2_HUMAN (11-1593): 0: 1683: 100.00
+	Hs
		1246365 PDIP3_HUMAN (58-192): 2.97e-15: 76.5: 30.15		THOC2_HUMAN (11-1593): 0: 1683: 100.00
+	Sc
		862774 YRA1_YEAST (1-253): 3.87e-36: 129: 22.44		THO2_YEAST (66-1590): 0: 938: 18.17
+	Sc
		376876 PABP_YEAST (88-193): 1.79e-17: 83.2: 23.36		THO2_YEAST (66-1590): 0: 938: 18.17
+	Hs
		1201136 THOC4_HUMAN (1-257): 3.25e-47: 159: 100.00		IWS1_HUMAN (1182-1587): 9.15e-17: 88.4: 12.90
+	Hs
		1132706 THOC4_HUMAN (1-257): 3.25e-47: 159: 100.00		ZC3HD_HUMAN (1120-1593): 6.09e-11: 69.9: 8.37
+	Hs
		1154073 PDIP3_HUMAN (58-192): 2.97e-15: 76.5: 30.15		NIPBL_HUMAN (1209-1593): 5.86e-22: 106: 14.83
+	Hs
		832977 PABP4_HUMAN (97-252): 3.94e-21: 94: 19.50		YLPM1_HUMAN (1134-1593): 5.81e-11: 69.9: 9.62