Protein: STYX
Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein)

Gene: STYX
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q8WUJ0

Gene Ontology (top 5):
GO:0001691 - pseudophosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

703661

MK01
Mitogen-activated protein kinase 1

1

20

Small-scale

0.713

High

1356792

FBXW7
F-box/WD repeat-containing protein 7

4

2

Small-scale

0.710

High

181807

EPHB6
Ephrin type-B receptor 6

1

20

High-throughput

0.698

High

710394

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.698

High

710646

EPHA3
Ephrin type-A receptor 3

1

20

High-throughput

0.698

High

1038459

TIE2
Angiopoietin-1 receptor

1

18

High-throughput

0.698

High

1147391

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.698

High

354745

PAK4
Serine/threonine-protein kinase PAK 4

1

2

High-throughput

0.691

High

1356798

FXL12
F-box/LRR-repeat protein 12

4

3

Small-scale

0.686

High

1244805

FBX38
F-box only protein 38

3

0

Small-scale

0.638

High

439800

INSR
Insulin receptor

1

20

High-throughput

0.625

High

572947

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.625

High

262547

MCE1
mRNA-capping enzyme

1

7

High-throughput

0.618

High

1356788

STYX
Serine/threonine/tyrosine-interacting protein

1

19

High-throughput

0.618

High

911321

IMA5
Importin subunit alpha-5

2

1

High-throughput

0.611

High

1030748

CAP1
Adenylyl cyclase-associated protein 1

2

1

Small-scale

0.611

High

1356662

ARB2A
Cotranscriptional regulator ARB2A

2

0

Small-scale

0.602

High

992279

SKP1
S-phase kinase-associated protein 1

2

0

High-throughput

0.585

High

1194616

DUS28
Dual specificity phosphatase 28

1

16

High-throughput

0.553

High

363620

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.541

High

410962

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.541

High

778086

VGFR2
Vascular endothelial growth factor receptor 2

1

13

High-throughput

0.541

High

1034182

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.541

High

1101761

PTK7
Inactive tyrosine-protein kinase 7

1

10

High-throughput

0.541

High

1145756

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.541

High

552848

TPR
Nucleoprotein TPR

1

9

Small-scale

0.536

High

563064

MYH8
Myosin-8

1

2

High-throughput

0.536

High

600876

HSP76
Heat shock 70 kDa protein 6

1

4

High-throughput

0.536

High

717326

PEBP1
Phosphatidylethanolamine-binding protein 1

1

1

Small-scale

0.536

High

912206

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

1

High-throughput

0.536

High

1005924

GTF2I
General transcription factor II-I

1

1

Small-scale

0.536

High

1024722

VIGLN
Vigilin

1

8

High-throughput

0.536

High

1148528

SF3B4
Splicing factor 3B subunit 4

1

6

High-throughput

0.536

High

1201007

ACTBL
Beta-actin-like protein 2

1

12

Small-scale

0.536

High

1295693

HORN
Hornerin

1

1

Small-scale

0.536

High

1323392

FXL14
F-box/LRR-repeat protein 14

1

1

High-throughput

0.536

High

1356790

PSPC1
Paraspeckle component 1

1

5

Small-scale

0.536

High

1356791

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

High-throughput

0.536

High

285697

BAF
Barrier-to-autointegration factor

1

0

Small-scale

0.513

High

559694

UNG
Uracil-DNA glycosylase

1

0

Small-scale

0.513

High

589252

RFA2
Replication protein A 32 kDa subunit

1

0

Small-scale

0.513

High

716388

BLVRB
Flavin reductase

1

0

Small-scale

0.513

High

784869

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

1

0

Small-scale

0.513

High

1089332

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

0

Small-scale

0.513

High

1206815

COA6
Cytochrome c oxidase assembly factor 6 homolog

1

0

Small-scale

0.513

High

1220940

FBX31
F-box only protein 31

1

0

Small-scale

0.513

High

1235615

K2C80
Keratin, type II cytoskeletal 80

1

0

Small-scale

0.513

High

1356789

MITD1
MIT domain-containing protein 1

1

0

Small-scale

0.513

High

1356794

ASHWN
Ashwin

1

0

Small-scale

0.513

High

1356802

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

179623

MUSK
Muscle, skeletal receptor tyrosine-protein kinase

1

20

High-throughput

0.494

High

465586

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.494

High

532091

KIT
Mast/stem cell growth factor receptor Kit

1

13

High-throughput

0.494

High

641634

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.494

High

1034302

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.494

High

1251932

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.494

High

1310860

LMTK2
Serine/threonine-protein kinase LMTK2

1

20

High-throughput

0.494

High

1356799

RRBP1
Ribosome-binding protein 1

1

5

Small-scale

0.489

High

660124

COF1
Cofilin-1

1

6

High-throughput

0.479

High

818803

CAP2
Adenylyl cyclase-associated protein 2

1

1

High-throughput

0.479

High

841842

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

10

High-throughput

0.479

High

866764

CAZA2
F-actin-capping protein subunit alpha-2

1

4

High-throughput

0.479

High

867295

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

888204

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.479

High

915141

CAZA1
F-actin-capping protein subunit alpha-1

1

4

High-throughput

0.479

High

981608

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.479

High

1016538

SRSF3
Serine/arginine-rich splicing factor 3

1

10

High-throughput

0.479

High

1085903

TWF1
Twinfilin-1

1

6

High-throughput

0.479

High

1112622

CUL1
Cullin-1

1

4

High-throughput

0.479

High

1233255

ELP2
Elongator complex protein 2

1

3

High-throughput

0.479

High

1233710

TWF2
Twinfilin-2

1

6

High-throughput

0.479

High

1356796

NJMU
Protein Njmu-R1

1

1

High-throughput

0.479

High

1116549

FHL3
Four and a half LIM domains protein 3

1

0

High-throughput

0.458

High

1356795

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.458

High

1356797

TLR9
Toll-like receptor 9

1

0

High-throughput

0.458

High

1356800

SRRM2
Serine/arginine repetitive matrix protein 2

1

0

High-throughput

0.458

High

568456

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

289796

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.279

Low

1280190

FBX33
F-box only protein 33

1

0

High-throughput

0.279

Low

1356801

LTOR2
Ragulator complex protein LAMTOR2

1

0

High-throughput

0.279

Low

1356793

GAR1B
Golgi-associated RAB2 interactor protein 1B

1

0

High-throughput

0.269

Low

1225953

F91A1
Protein FAM91A1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025