HitPredict

Interactor 1: TLR4 (O00206)
Toll-like receptor 4 (hToll) (CD antigen CD284)
Gene: TLR4

Interactor 2: TOLIP (Q9H0E2)
Toll-interacting protein
Gene: TOLLIP

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	11751856, 11441107
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005769 - early endosome GO:0006954 - inflammatory response GO:0045087 - innate immune response GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 839 Hs			1 274
+	Hs
		237519 TLR2_HUMAN (19-815): 1.12e-90: 305: 22.15		TOLIP_HUMAN (1-274): 6.84e-178: 492: 100.00
+	Hs
		1327586 TLR9_HUMAN (9-650): 1.19e-47: 185: 17.12		TOLIP_HUMAN (1-274): 6.84e-178: 492: 100.00
+	Hs
		179960 TLR3_HUMAN (3-164): 4.58e-09: 62.1: 17.54		TOLIP_HUMAN (1-274): 6.84e-178: 492: 100.00