HitPredict

Interactor 1: MIB1 (Q86YT6)
E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2)
Gene: MIB1

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	21903422, 31462741
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1006 Hs			1 729
+	Mm
		1193400 MIB1_MOUSE (1-1006): 0: 870: 99.30		TBK1_MOUSE (1-729): 0: 558: 94.10
+	Hs
		1284698 MIB2_HUMAN (14-1006): 0: 593: 29.05		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		167031 ANR28_HUMAN (169-452): 1.58e-23: 109: 11.11		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		862115 DAPK1_HUMAN (464-599): 1.59e-10: 67.4: 30.88		MARK1_HUMAN (9-407): 5.07e-87: 292: 23.33
+	Hs
		647851 DAPK1_HUMAN (464-599): 1.59e-10: 67.4: 30.88		MARK3_HUMAN (9-267): 1.86e-85: 287: 28.08
+	Dm
		1362718 ANKHM_DROME (188-326): 1.53e-09: 64.4: 9.35		IKKB_DROME (1-316): 1.37e-24: 111: 30.29