Interactor 1: LRRK2 (Q5S006)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-)
Gene: LRRK2

Interactor 2: LRRK2 (Q5S006)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-)
Gene: LRRK2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.923

The method score is based on:

Property Details
Experiments 20659021, 17623048, 21390248, 27357661, 22952686
Identification Methods enzymatic study, affinity chromatography technology, blue native page, electron microscopy, protein kinase assay, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains COR~COR, COR~Pkinase, COR~Roc, LRR_1~LRR_1, LRR_1~LRR_8, LRR_8~LRR_8, LRR_8~Pkinase, Pkinase~Pkinase, Roc~Roc
Common GO terms GO:0000139 - Golgi membrane
GO:0000287 - magnesium ion binding
GO:0003779 - actin binding
GO:0003924 - GTPase activity
GO:0004672 - protein kinase activity
and 127 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 11Aug2025