Protein: MATK
Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK)

Gene: MATK
Organism: Homo sapiens
Interactions: 41
UniProt ID: P42679

Gene Ontology (top 5):
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

410688

ERBB2
Receptor tyrosine-protein kinase erbB-2

3

20

Small-scale

0.857

High

834150

CSK
Tyrosine-protein kinase CSK

2

19

High-throughput

0.811

High

840856

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

18

Small-scale

0.799

High

532055

KIT
Mast/stem cell growth factor receptor Kit

2

20

Small-scale

0.778

High

840854

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

7

High-throughput

0.778

High

411523

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.724

High

840847

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

3

4

Small-scale

0.693

High

472016

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

468151

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.665

High

840862

BACE2
Beta-secretase 2

1

1

High-throughput

0.665

High

557157

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.647

High

641510

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

658860

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

20

Small-scale

0.647

High

728088

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.647

High

840844

MATK
Megakaryocyte-associated tyrosine-protein kinase

1

19

Small-scale

0.647

High

840849

ILK
Scaffold protein ILK

1

17

Small-scale

0.647

High

840852

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

840860

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

15

Small-scale

0.647

High

840851

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.625

High

362923

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

461243

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

465445

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.618

High

730430

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

840846

1433E
14-3-3 protein epsilon

1

5

High-throughput

0.618

High

840853

CDC37
Hsp90 co-chaperone Cdc37

1

17

High-throughput

0.618

High

220226

FRS3
Fibroblast growth factor receptor substrate 3

2

20

High-throughput

0.594

High

840859

KLK6
Kallikrein-6

1

0

High-throughput

0.556

High

840848

EWS
RNA-binding protein EWS

1

4

High-throughput

0.541

High

519813

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

139691

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

5

High-throughput

0.508

High

534749

BIP
Endoplasmic reticulum chaperone BiP

1

20

Small-scale

0.501

High

801206

HSPA9
Stress-70 protein, mitochondrial

1

20

Small-scale

0.501

High

598585

CD36
Platelet glycoprotein 4

1

6

Small-scale

0.479

High

798803

BRCA1
Breast cancer type 1 susceptibility protein

1

9

Small-scale

0.479

High

840845

PAXI
Paxillin

1

20

Small-scale

0.479

High

840850

CUL3
Cullin-3

1

4

High-throughput

0.479

High

840858

NUDC2
NudC domain-containing protein 2

1

3

High-throughput

0.479

High

840861

XPO7
Exportin-7

1

2

High-throughput

0.437

High

840855

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

840857

NOC3L
Nucleolar complex protein 3 homolog

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025