Protein: LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)

Gene: LRRK1
Organism: Homo sapiens
Interactions: 118
UniProt ID: Q38SD2

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005525 - GTP binding
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363363

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.861

High

362304

ABL1
Tyrosine-protein kinase ABL1

3

6

High-throughput

0.857

High

1182832

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

20

Small-scale

0.836

High

920001

PLK1
Serine/threonine-protein kinase PLK1

2

9

Small-scale

0.834

High

1182835

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

20

Small-scale

0.789

High

461545

HS90A
Heat shock protein HSP 90-alpha

2

10

Small-scale

0.789

High

171713

GAK
Cyclin-G-associated kinase

2

8

High-throughput

0.778

High

463978

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

10

High-throughput

0.778

High

641184

FGFR2
Fibroblast growth factor receptor 2

2

8

High-throughput

0.778

High

710712

EPHA8
Ephrin type-A receptor 8

2

20

High-throughput

0.778

High

777698

VGFR3
Vascular endothelial growth factor receptor 3

2

5

High-throughput

0.778

High

840854

MATK
Megakaryocyte-associated tyrosine-protein kinase

2

7

High-throughput

0.778

High

1182855

NEK1
Serine/threonine-protein kinase Nek1

2

14

High-throughput

0.778

High

1182858

BAG1
BAG family molecular chaperone regulator 1

2

2

High-throughput

0.778

High

1182867

PAK6
Serine/threonine-protein kinase PAK 6

2

9

High-throughput

0.778

High

1182872

BORG2
Cdc42 effector protein 3

2

2

High-throughput

0.778

High

468438

HS90B
Heat shock protein HSP 90-beta

2

10

High-throughput

0.776

High

987677

GRB2
Growth factor receptor-bound protein 2

5

6

High-throughput

0.703

High

1182873

BAG5
BAG family molecular chaperone regulator 5

3

4

Small-scale

0.674

High

711365

SHC1
SHC-transforming protein 1

4

5

High-throughput

0.666

High

354712

PAK4
Serine/threonine-protein kinase PAK 4

1

8

High-throughput

0.665

High

920450

DAPK1
Death-associated protein kinase 1

1

6

Small-scale

0.665

High

1107782

SQSTM
Sequestosome-1

1

4

Small-scale

0.665

High

170507

RAB7L
Ras-related protein Rab-7L1

1

17

High-throughput

0.647

High

443390

CDK1
Cyclin-dependent kinase 1

1

9

Small-scale

0.647

High

840886

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.647

High

1182842

FXL14
F-box/LRR-repeat protein 14

1

20

High-throughput

0.647

High

187358

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

3

High-throughput

0.618

High

727827

DNJA1
DnaJ homolog subfamily A member 1

1

6

High-throughput

0.618

High

1105944

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

7

High-throughput

0.618

High

1148243

RSU1
Ras suppressor protein 1

1

20

High-throughput

0.618

High

1158342

CDC37
Hsp90 co-chaperone Cdc37

1

3

High-throughput

0.618

High

1182850

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

10

High-throughput

0.618

High

1182874

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.618

High

1182876

GAB2
GRB2-associated-binding protein 2

1

4

High-throughput

0.618

High

1007039

TCPB
T-complex protein 1 subunit beta

2

10

High-throughput

0.611

High

328438

SCEL
Sciellin

2

1

High-throughput

0.602

High

335855

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

2

1

High-throughput

0.602

High

347066

BAG2
BAG family molecular chaperone regulator 2

2

4

High-throughput

0.602

High

347736

BAG3
BAG family molecular chaperone regulator 3

2

4

High-throughput

0.602

High

618461

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

2

4

High-throughput

0.602

High

717094

ECHM
Enoyl-CoA hydratase, mitochondrial

2

5

High-throughput

0.602

High

1097940

CBLB
E3 ubiquitin-protein ligase CBL-B

2

6

High-throughput

0.602

High

1182833

PDCD4
Programmed cell death protein 4

2

4

High-throughput

0.602

High

1182834

ODFP2
Outer dense fiber protein 2

2

6

High-throughput

0.602

High

1182853

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

6

High-throughput

0.602

High

1182859

TCF25
Ribosome quality control complex subunit TCF25

2

1

High-throughput

0.602

High

1182862

FOXP1
Forkhead box protein P1

2

2

High-throughput

0.602

High

1182869

CWC15
Spliceosome-associated protein CWC15 homolog

2

1

High-throughput

0.602

High

1182875

CHIP
E3 ubiquitin-protein ligase CHIP

2

9

High-throughput

0.602

High

1182878

SNX9
Sorting nexin-9

2

3

High-throughput

0.602

High

537261

HSP7C
Heat shock cognate 71 kDa protein

2

7

Small-scale

0.601

High

1182856

CK5P2
CDK5 regulatory subunit-associated protein 2

1

10

Small-scale

0.589

High

946663

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

2

0

High-throughput

0.577

High

1117383

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

10

High-throughput

0.575

High

141756

CCL21
C-C motif chemokine 21

2

1

High-throughput

0.550

High

211205

CMIP4
Ciliary microtubule inner protein 4

2

1

High-throughput

0.550

High

421163

SCG1
Secretogranin-1

2

5

High-throughput

0.550

High

1121007

VGLL4
Transcription cofactor vestigial-like protein 4

2

2

High-throughput

0.550

High

1182848

CKAP2
Cytoskeleton-associated protein 2

2

1

High-throughput

0.550

High

1182865

GPBL1
Vasculin-like protein 1

2

2

High-throughput

0.550

High

540027

BCR
Breakpoint cluster region protein

1

6

High-throughput

0.536

High

610685

TCPA
T-complex protein 1 subunit alpha

1

8

High-throughput

0.536

High

821378

TCPZ
T-complex protein 1 subunit zeta

1

8

High-throughput

0.536

High

875984

TCPE
T-complex protein 1 subunit epsilon

1

10

High-throughput

0.536

High

881946

TCPG
T-complex protein 1 subunit gamma

1

10

High-throughput

0.536

High

899060

TCPQ
T-complex protein 1 subunit theta

1

12

High-throughput

0.536

High

899408

TCPD
T-complex protein 1 subunit delta

1

8

High-throughput

0.536

High

916664

PPP5
Serine/threonine-protein phosphatase 5

1

8

High-throughput

0.536

High

1182857

TCPH
T-complex protein 1 subunit eta

1

10

High-throughput

0.536

High

1182864

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.536

High

1182868

SHLB2
Endophilin-B2

1

7

High-throughput

0.536

High

1182877

SGT1
Protein SGT1 homolog

1

10

High-throughput

0.536

High

424207

S10A8
Protein S100-A8

1

5

High-throughput

0.515

High

1182839

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

1

High-throughput

0.515

High

331021

KI20A
Kinesin-like protein KIF20A

1

8

High-throughput

0.501

High

1182844

F184A
Protein FAM184A

1

9

High-throughput

0.501

High

1182861

MTG1
Mitochondrial ribosome-associated GTPase 1

1

3

High-throughput

0.501

High

1182866

SH22A
SH2 domain-containing protein 2A

1

7

High-throughput

0.501

High

1182871

TR112
Multifunctional methyltransferase subunit TRM112-like protein

1

1

High-throughput

0.501

High

448035

ITAV
Integrin alpha-V

1

0

High-throughput

0.493

High

1182840

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

7

High-throughput

0.489

High

1182847

CPLX3
Complexin-3

1

0

High-throughput

0.480

High

565922

EF2
Elongation factor 2

1

5

High-throughput

0.479

High

799174

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

861632

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

6

High-throughput

0.479

High

1053673

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

2

High-throughput

0.479

High

1060678

SOS1
Son of sevenless homolog 1

1

3

High-throughput

0.479

High

1060711

SOS2
Son of sevenless homolog 2

1

2

High-throughput

0.479

High

1113245

CUL3
Cullin-3

1

5

Small-scale

0.479

High

1182838

DOK3
Docking protein 3

1

2

High-throughput

0.479

High

1182849

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

3

High-throughput

0.479

High

963184

LYSC
Lysozyme C

1

1

High-throughput

0.470

High

958956

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

1182870

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.458

High

506011

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

1

High-throughput

0.457

High

1182837

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

1

High-throughput

0.457

High

1182845

ENKUR
Enkurin

1

1

High-throughput

0.457

High

1182863

LMA1L
Protein ERGIC-53-like

1

1

High-throughput

0.457

High

224720

ACTN4
Alpha-actinin-4

1

4

High-throughput

0.445

High

428155

RLA1
Large ribosomal subunit protein P1

1

1

High-throughput

0.445

High

457475

TBB5
Tubulin beta chain

1

9

High-throughput

0.445

High

997362

TBB4B
Tubulin beta-4B chain

1

9

High-throughput

0.445

High

1028785

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

8

High-throughput

0.445

High

936765

NP1L1
Nucleosome assembly protein 1-like 1

1

5

High-throughput

0.437

High

965705

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

12

High-throughput

0.437

High

183855

VGF
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1

1

1

High-throughput

0.407

High

1160640

DREB
Drebrin

1

3

High-throughput

0.407

High

1182841

CLVS1
Clavesin-1

2

0

High-throughput

0.314

High

1182846

BL1S5
Biogenesis of lysosome-related organelles complex 1 subunit 5

2

0

High-throughput

0.314

High

1182851

SNX21
Sorting nexin-21

2

0

High-throughput

0.314

High

1182860

TIRR
Tudor-interacting repair regulator protein

2

0

High-throughput

0.314

High

1182836

SKT
Sickle tail protein homolog

1

0

High-throughput

0.261

Low

1182852

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.261

Low

49365

A0N4V7
HCG2039797

1

0

High-throughput

0.249

Low

1182843

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.249

Low

1182854

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025