Protein: VKGC
Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase)

Gene: VKGC, GGCX
Organism: Homo sapiens
Interactions: 64
UniProt ID: P38435

Gene Ontology (top 5):
GO:0005789 - endoplasmic reticulum membrane
GO:0007596 - blood coagulation
GO:0008488 - gamma-glutamyl carboxylase activity
GO:0016020 - membrane
GO:0019842 - vitamin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

750582

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

0

High-throughput

0.602

High

369111

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

750601

FBX6
F-box only protein 6

2

1

High-throughput

0.558

High

171949

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

750596

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

1

High-throughput

0.536

High

750609

FBX2
F-box only protein 2

1

1

High-throughput

0.536

High

49404

TMM72
Transmembrane protein 72

1

0

High-throughput

0.513

High

540278

GPIX
Platelet glycoprotein IX

1

0

High-throughput

0.513

High

596130

C4BPB
C4b-binding protein beta chain

1

0

High-throughput

0.513

High

654128

CALX
Calnexin

1

0

High-throughput

0.513

High

750587

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

750590

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

750592

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

750598

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

750600

ENTP7
Ectonucleoside triphosphate diphosphohydrolase 7

1

0

High-throughput

0.513

High

750608

CLC2D
C-type lectin domain family 2 member D

1

0

High-throughput

0.513

High

152183

TMG1
Transmembrane gamma-carboxyglutamic acid protein 1

1

1

High-throughput

0.489

High

156802

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.489

High

664352

AA2BR
Adenosine receptor A2b

1

1

High-throughput

0.489

High

723277

APJ
Apelin receptor

1

1

High-throughput

0.489

High

750573

CXCR4
C-X-C chemokine receptor type 4

1

1

High-throughput

0.489

High

750611

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

163764

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

718563

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

750578

CUL3
Cullin-3

1

0

High-throughput

0.458

High

750594

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

750595

DERL1
Derlin-1

1

0

High-throughput

0.458

High

750591

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

354333

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.426

High

750588

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

131877

UPK2
Uroplakin-2

1

0

High-throughput

0.279

Low

206464

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.279

Low

245317

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

450640

PAEP
Glycodelin

1

0

High-throughput

0.279

Low

702199

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

750572

AP1S2
AP-1 complex subunit sigma-2

1

0

High-throughput

0.279

Low

750576

FGD1
FYVE, RhoGEF and PH domain-containing protein 1

1

0

High-throughput

0.279

Low

750580

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

750585

S22A9
Organic anion transporter 7

1

0

High-throughput

0.279

Low

750586

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

750589

GPBAR
G-protein coupled bile acid receptor 1

1

0

High-throughput

0.279

Low

750593

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.279

Low

750599

NPDC1
Neural proliferation differentiation and control protein 1

1

0

High-throughput

0.279

Low

750603

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.279

Low

750605

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

750606

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

161980

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

0

High-throughput

0.269

Low

750579

SAFB1
Scaffold attachment factor B1

1

0

High-throughput

0.269

Low

750575

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.261

Low

205122

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

351968

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

373809

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

650538

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

750571

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.249

Low

750574

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

750577

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

750581

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

750583

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

750584

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.249

Low

750597

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

750602

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

750604

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.249

Low

750607

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

750610

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024