HitPredict

Interactor 1: M4K3 (Q8IVH8)
Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)
Gene: MAP4K3

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32640226
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Hs			1 347
+	Hs
		1217584 M4K3_HUMAN (1-894): 0: 1060: 100.00		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		1307427 M4K5_HUMAN (1-894): 0: 940: 65.41		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		1217586 M4K3_HUMAN (1-894): 0: 1060: 100.00		SRBS1_HUMAN (169-342): 1.13e-13: 74.1: 17.65
+	Hs
		1191846 M4K3_HUMAN (1-894): 0: 1060: 100.00		SH3R1_HUMAN (271-339): 2.43e-11: 66.8: 20.83
+	Hs
		924683 M4K3_HUMAN (1-894): 0: 1060: 100.00		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		1052362 M4K5_HUMAN (1-894): 0: 940: 65.41		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Hs
		924984 M4K5_HUMAN (1-894): 0: 940: 65.41		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		536584 M4K1_HUMAN (6-893): 0: 782: 39.19		HCLS1_HUMAN (6-343): 2.65e-35: 135: 12.02
+	Hs
		924745 M4K1_HUMAN (6-893): 0: 782: 39.19		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		1023121 STK4_HUMAN (10-288): 2.22e-119: 373: 46.43		SHLB2_HUMAN (10-342): 1.05e-58: 196: 20.57
+	Hs
		1089313 STK24_HUMAN (9-291): 7.65e-116: 362: 46.67		RHG44_HUMAN (6-252): 4.15e-52: 186: 22.10
+	Hs
		1052339 STK26_HUMAN (3-291): 7.94e-118: 366: 46.05		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Mm
		949306 TNIK_MOUSE (6-290): 5.69e-73: 264: 48.32		SH3G2_MOUSE (1-347): 4.35e-85: 262: 65.63
+	Hs
		596215 STK3_HUMAN (10-288): 2.29e-117: 368: 45.36		NEBU_HUMAN (7-342): 2.57e-37: 144: 16.06
+	Hs
		682008 AKT1_HUMAN (6-341): 6.7e-134: 410: 23.70		SRBS1_HUMAN (169-342): 1.13e-13: 74.1: 17.65
+	Hs
		681922 AKT1_HUMAN (6-341): 6.7e-134: 410: 23.70		SH3R1_HUMAN (271-339): 2.43e-11: 66.8: 20.83
+	Hs
		682191 AKT2_HUMAN (5-344): 8.04e-134: 410: 22.92		SH3R1_HUMAN (271-339): 2.43e-11: 66.8: 20.83
+	Hs
		298951 AKT2_HUMAN (5-344): 8.04e-134: 410: 22.92		SRBS2_HUMAN (291-344): 2.01e-10: 64.3: 48.15
+	Dm
		993188 Q7KV89_DROME (10-313): 7.02e-77: 273: 45.99		GRAP_DROME (272-339): 1.72e-20: 90.2: 40.85
+	Mm
		949279 TNIK_MOUSE (6-290): 5.69e-73: 264: 48.32		SRBS2_MOUSE (243-342): 8.22e-12: 68.5: 20.59