HitPredict

Interactor 1: BRE1A (Q5VTR2)
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
Gene: RNF20

Interactor 2: H32 (Q71DI3)
Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o)
Gene: H3C15

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21443952
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 975 Hs			1 136
+	Sc
		963752 BRE1_YEAST (509-974): 2.64e-58: 215: 19.14		H3_YEAST (1-136): 1.23e-55: 171: 88.97
+	Hs
		270798 ROCK2_HUMAN (96-897): 2.16e-15: 83.5: 14.08		H31_HUMAN (1-136): 3.1e-62: 188: 99.27
+	Hs
		157532 CTRO_HUMAN (49-890): 1e-14: 81.5: 14.94		H32_HUMAN (1-136): 6.24e-61: 185: 100.00
+	Hs
		772736 MYH9_HUMAN (561-959): 1.37e-13: 77.5: 9.59		H31_HUMAN (1-136): 3.1e-62: 188: 99.27
+	Hs
		773155 MYH10_HUMAN (1-355): 1.6e-13: 77.5: 9.47		H31_HUMAN (1-136): 3.1e-62: 188: 99.27
+	Hs
		773213 MYH10_HUMAN (1-355): 1.6e-13: 77.5: 9.47		H32_HUMAN (1-136): 6.24e-61: 185: 100.00
+	Hs
		587617 DESP_HUMAN (225-919): 9.05e-12: 71.9: 16.12		H31_HUMAN (1-136): 3.1e-62: 188: 99.27
+	Hs
		157505 CTRO_HUMAN (49-890): 1e-14: 81.5: 14.94		H3C_HUMAN (1-136): 5.27e-58: 177: 94.12
+	Hs
		587709 DESP_HUMAN (225-919): 9.05e-12: 71.9: 16.12		H32_HUMAN (1-136): 6.24e-61: 185: 100.00
+	Hs
		998966 MYH15_HUMAN (528-924): 1.43e-10: 67.8: 10.58		H31_HUMAN (1-136): 3.1e-62: 188: 99.27
+	Hs
		998620 MY18A_HUMAN (326-919): 1.43e-10: 67.7: 15.69		H31_HUMAN (1-136): 3.1e-62: 188: 99.27
+	Hs
		587590 DESP_HUMAN (225-919): 9.05e-12: 71.9: 16.12		CENPA_HUMAN (9-133): 2.87e-44: 143: 50.00