Protein: BRE1
E3 ubiquitin-protein ligase BRE1 (EC 2.3.2.27) (Brefeldin A-sensitivity protein 1) (RING-type E3 ubiquitin transferase BRE1)

Gene: BRE1
Organism: Saccharomyces cerevisiae S288C
Interactions: 162
UniProt ID: Q07457

Gene Ontology (top 5):
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0003688 - DNA replication origin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

438550

UBC2
Ubiquitin-conjugating enzyme E2 2

18

20

Small-scale

0.990

High

1059344

BRE1
E3 ubiquitin-protein ligase BRE1

11

17

Small-scale

0.976

High

381289

H2B1
Histone H2B.1

5

20

Small-scale

0.937

High

381651

H2B2
Histone H2B.2

4

20

Small-scale

0.886

High

419519

H2A1
Histone H2A.1

2

18

Small-scale

0.778

High

574819

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

20

Small-scale

0.724

High

1038824

LGE1
Transcriptional regulatory protein LGE1

7

0

Small-scale

0.713

High

755304

NUF2
Kinetochore protein NUF2

3

13

High-throughput

0.645

High

647846

RFA1
Replication factor A protein 1

2

9

Small-scale

0.624

High

546466

SSB1
Ribosome-associated molecular chaperone SSB1

3

15

High-throughput

0.624

High

594592

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

Small-scale

0.584

High

580149

HSC82
ATP-dependent molecular chaperone HSC82

3

17

Small-scale

0.578

High

708323

TF2B
Transcription initiation factor IIB

2

2

High-throughput

0.576

High

419889

H2A2
Histone H2A.2

1

18

High-throughput

0.575

High

963752

H3
Histone H3

1

14

High-throughput

0.575

High

393415

HSP82
ATP-dependent molecular chaperone HSP82

2

17

High-throughput

0.571

High

819928

SSB2
Ribosome-associated molecular chaperone SSB2

2

15

Small-scale

0.571

High

1031059

NOP3
Serine/arginine

2

17

Small-scale

0.571

High

557778

SRS2
ATP-dependent DNA helicase SRS2

1

3

Small-scale

0.561

High

675352

RAD51
DNA repair protein RAD51

1

6

Small-scale

0.561

High

863962

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

9

Small-scale

0.561

High

637290

PWP1
Periodic tryptophan protein 1

1

19

High-throughput

0.541

High

738434

EIF3C
Eukaryotic translation initiation factor 3 subunit C

2

1

Small-scale

0.533

High

747605

RSSA1
Small ribosomal subunit protein uS2A

2

3

High-throughput

0.521

High

1054993

SP382
Pre-mRNA-splicing factor SPP382

1

0

High-throughput

0.518

High

1054366

JIP5
WD repeat-containing protein JIP5

1

14

High-throughput

0.515

High

747762

SMC1
Structural maintenance of chromosomes protein 1

1

13

High-throughput

0.508

High

808607

SMC2
Structural maintenance of chromosomes protein 2

1

14

High-throughput

0.508

High

864376

SMC3
Structural maintenance of chromosomes protein 3

1

17

High-throughput

0.508

High

758336

HSL1
Probable serine/threonine-protein kinase HSL1

1

18

High-throughput

0.501

High

781161

SWD2
COMPASS component SWD2

1

20

Small-scale

0.501

High

798623

PAF1
RNA polymerase II-associated protein 1

1

2

Small-scale

0.501

High

757414

TFC3
Transcription factor tau 138 kDa subunit

1

0

High-throughput

0.493

High

1056296

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.486

High

402130

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

Small-scale

0.479

High

435392

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

666555

DBP2
ATP-dependent RNA helicase DBP2

1

6

Small-scale

0.479

High

676773

GBP2
Serine/arginine

1

6

Small-scale

0.479

High

692636

NSR1
Nuclear localization sequence-binding protein

1

7

Small-scale

0.479

High

735187

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

778559

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

779108

EF1G2
Elongation factor 1-gamma 2

1

6

Small-scale

0.479

High

792272

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.479

High

826094

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.479

High

834793

ERG10
Acetyl-CoA acetyltransferase

1

3

Small-scale

0.479

High

916535

SAP4
SIT4-associating protein SAP4

1

1

High-throughput

0.479

High

1044782

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

1053869

IMB1
Importin subunit beta-1

1

4

Small-scale

0.479

High

1059349

NCBP2
Nuclear cap-binding protein subunit 2

1

9

High-throughput

0.479

High

1059354

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

1059346

SLK19
Kinetochore protein SLK19

1

20

High-throughput

0.464

High

735411

MCM10
Minichromosome maintenance protein 10

1

0

Small-scale

0.458

High

748070

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

781523

YKR18
IML2-like protein YKR018C

1

0

High-throughput

0.458

High

824951

TM108
Protein TMA108

1

0

High-throughput

0.458

High

826879

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

865764

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

1044309

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

1059345

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.458

High

1059351

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

1059353

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

1059356

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.458

High

808424

HAL5
Serine/threonine-protein kinase HAL5

1

19

High-throughput

0.457

High

1040425

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

20

High-throughput

0.457

High

366843

IPYR
Inorganic pyrophosphatase

1

1

High-throughput

0.445

High

382377

H4
Histone H4

1

13

High-throughput

0.445

High

486327

TBA1
Tubulin alpha-1 chain

1

3

High-throughput

0.445

High

525307

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.445

High

527806

HSP72
Heat shock protein SSA2

1

15

High-throughput

0.445

High

576012

CYPH
Peptidyl-prolyl cis-trans isomerase

1

7

High-throughput

0.445

High

614851

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

18

High-throughput

0.445

High

646092

KIN3
Serine/threonine-protein kinase KIN3

1

20

High-throughput

0.445

High

664354

SSD1
Protein SSD1

1

2

High-throughput

0.445

High

676396

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

734482

BTAF1
TATA-binding protein-associated factor MOT1

1

18

High-throughput

0.445

High

736050

SP110
Spindle pole body component 110

1

18

High-throughput

0.445

High

737429

FKBP2
Peptidyl-prolyl cis-trans isomerase FPR2

1

4

High-throughput

0.445

High

742511

HSP7F
Heat shock protein homolog SSE1

1

17

High-throughput

0.445

High

743146

STH1
Nuclear protein STH1/NPS1

1

13

High-throughput

0.445

High

762873

TOR1
Serine/threonine-protein kinase TOR1

1

12

High-throughput

0.445

High

763381

TAF14
Transcription initiation factor TFIID subunit 14

1

1

High-throughput

0.445

High

781811

SET3
SET domain-containing protein 3

1

8

High-throughput

0.445

High

793871

SWD3
COMPASS component SWD3

1

20

High-throughput

0.445

High

794006

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

16

High-throughput

0.445

High

794228

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

17

High-throughput

0.445

High

801936

KSP1
Serine/threonine-protein kinase KSP1

1

17

High-throughput

0.445

High

804502

SSZ1
Ribosome-associated complex subunit SSZ1

1

13

High-throughput

0.445

High

805579

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

11

High-throughput

0.445

High

811416

CAJ1
Protein CAJ1

1

8

High-throughput

0.445

High

849755

MOB2
CBK1 kinase activator protein MOB2

1

4

High-throughput

0.445

High

924067

JJJ1
J protein JJJ1

1

10

High-throughput

0.445

High

924427

CBK1
Serine/threonine-protein kinase CBK1

1

14

High-throughput

0.445

High

948670

ACT
Actin

1

20

High-throughput

0.445

High

1026836

CDC14
Tyrosine-protein phosphatase CDC14

1

14

High-throughput

0.445

High

1043978

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

2

High-throughput

0.445

High

149977

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

365700

PGK
Phosphoglycerate kinase

1

1

Small-scale

0.437

High

383917

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

410361

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

433871

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

436195

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

442133

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

455288

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

503266

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

512676

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

513246

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

514858

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.437

High

597564

EF3A
Elongation factor 3A

1

4

Small-scale

0.437

High

639576

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

1

High-throughput

0.437

High

674859

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

677883

ADY2
Accumulation of dyads protein 2

1

1

High-throughput

0.437

High

689689

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

747706

ATO2
Ammonia transport outward protein 2

1

1

High-throughput

0.437

High

753610

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

802413

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

812701

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

836918

MPG1
Mannose-1-phosphate guanyltransferase

1

1

Small-scale

0.437

High

874554

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

1033591

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

1059347

RS10A
Small ribosomal subunit protein eS10A

1

7

High-throughput

0.437

High

448475

RAD52
DNA repair and recombination protein RAD52

1

0

High-throughput

0.426

High

454009

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.426

High

653907

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

753044

SPC29
Spindle pole component 29

1

0

High-throughput

0.426

High

780986

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.426

High

916864

DXO
Decapping nuclease RAI1

1

0

High-throughput

0.426

High

921170

H1
Histone H1

1

0

High-throughput

0.426

High

1039904

TFB2
General transcription and DNA repair factor IIH subunit TFB2

1

0

High-throughput

0.426

High

1042350

SDC1
COMPASS component SDC1

1

0

High-throughput

0.426

High

1045045

PPN1
Endopolyphosphatase

1

0

High-throughput

0.426

High

1059352

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

1

0

High-throughput

0.426

High

445371

CDC31
Cell division control protein 31

1

4

High-throughput

0.407

High

453214

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

4

High-throughput

0.407

High

453319

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

4

High-throughput

0.407

High

510853

HSP77
Import motor subunit, mitochondrial

1

18

High-throughput

0.407

High

560769

KIN2
Serine/threonine-protein kinase KIN2

1

8

High-throughput

0.407

High

577227

SEC63
Protein translocation protein SEC63

1

7

High-throughput

0.407

High

623960

MYO2
Myosin-2

1

19

High-throughput

0.407

High

734624

NUD1
Protein NUD1

1

11

High-throughput

0.407

High

738116

MYO4
Myosin-4

1

18

High-throughput

0.407

High

752795

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

793210

AKL1
Serine/threonine-protein kinase AKL1

1

9

High-throughput

0.407

High

806370

KOG1
Target of rapamycin complex 1 subunit KOG1

1

17

High-throughput

0.407

High

812984

IMDH1
Putative inosine-5'-monophosphate dehydrogenase 1

1

4

High-throughput

0.407

High

834774

LST8
Target of rapamycin complex subunit LST8

1

14

High-throughput

0.407

High

863764

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

917638

MLC1
Myosin light chain 1

1

17

High-throughput

0.407

High

1056430

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

11

High-throughput

0.407

High

1059355

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

747083

SKG6
Protein SKG6

1

0

High-throughput

0.279

Low

394940

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.269

Low

1059348

YO365
Uncharacterized membrane protein YOR365C

1

0

High-throughput

0.269

Low

743886

YEF3
Uncharacterized protein YEL043W

1

0

High-throughput

0.265

Low

924504

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.265

Low

738565

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.232

Low

743649

RTG2
Retrograde regulation protein 2

1

0

High-throughput

0.232

Low

864336

NET1
Nucleolar protein NET1

1

0

High-throughput

0.232

Low

865485

BFA1
Mitotic check point protein BFA1

1

0

High-throughput

0.232

Low

893417

PSP2
Protein PSP2

1

0

High-throughput

0.232

Low

1055380

ATG33
Autophagy-related protein 33

1

0

High-throughput

0.232

Low

1059350

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025